Iodinated blood pool contrast media for preclinical X-ray imaging applications – A review

Hallouard, François; Anton, Nicolas; Choquet, Philippe; Constantinesco, A.; Vandamme, Thierry F.

doi:10.1016/j.biomaterials.2010.04.066

Cited by 232 publications

(204 citation statements)

References 246 publications

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“…Research essentially focuses [213,214] on the incorporation of the iodinated organic compounds into NPs, with designs ranging from emulsions [215 -218] , liposomes [214, 219 -223] , and lipoproteins [224,225] to insoluble nanoobjects [214, 226 -228] , and polymeric NPs [215, 229 -233] ; many of them have been successfully applied in vivo [28,56] . The purpose of these nanomaterials is to locally increase the iodine concentrations, resulting in a higher local contrast compared with the conventional water-soluble CT CAs.…”

Section: Iodinated Nanoparticlesmentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville

2013

Nanotechnology Reviews

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Abstract:The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in the synthesis protocol and characterization of these materials, whereas toxicological issues are sometimes incomplete. Nanoparticlebased contrast agents (CAs) tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of imaging modalities. The multimodal nanoparticles (NPs) are much more efficient than the conventional molecular-scale CAs. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity, and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides the specific applications for classical imaging (magnetic resonance imaging, positron emission tomography, computed tomography, ultrasound, and photoacoustic imaging), the less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA) are mentioned. The perspectives on the multimodal theranostic NPs and their potential for clinical advances are also mentioned.

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Section: Iodinated Nanoparticlesmentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville

2013

Nanotechnology Reviews

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“…11,13,27 Conventionally used small molecular iodinated CT contrast agents have a number of drawbacks, including potential renal toxicity, a brief time spent in the circulation and poor target specificity. 28,29 It is likely that the shortcomings mentioned earlier can be overcome by developing new types of non-iodinated CT contrast agents. For higher atomic numbers and electron densities greater than iodine, gold can be usefully incorporated into a new generation of contrast agents.…”

Section: Introductionmentioning

confidence: 99%

pH-sensitive Au–BSA–DOX–FA nanocomposites for combined CT imaging and targeted drug delivery

Huang

Yang

Liu

et al. 2017

IJN

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Albumin-based nanoparticles (NPs) as a drug delivery system have attracted much attention owing to their nontoxicity, non-immunogenicity, great stability and ability to bind to many therapeutic drugs. Herein, bovine serum albumin (BSA) was utilized as a template to prepare Au–BSA core/shell NPs. The outer layer BSA was subsequently conjugated with cis -aconityl doxorubicin (DOX) and folic acid (FA) to create Au–BSA–DOX–FA nanocomposites. A list of characterizations was undertaken to identify the successful conjugation of drug molecules and targeted agents. In vitro cytotoxicity using a cell counting kit-8 (CCK-8) assay indicated that Au–BSA NPs did not display obvious cytotoxicity to MGC-803 and GES-1 cells in the concentration range of 0–100 μg/mL, which can therefore be used as a safe drug delivery carrier. Furthermore, compared with free DOX, Au–BSA–DOX–FA nanocomposites exhibited a pH-sensitive drug release ability and superior antitumor activity in a drug concentration-dependent manner. In vivo computed tomography (CT) imaging experiments showed that Au–BSA–DOX–FA nanocomposites could be used as an efficient and durable CT contrast agent for targeted CT imaging of the folate receptor (FR) overexpressed in cancer tissues. In vivo antitumor experiments demonstrated that Au–BSA–DOX–FA nanocomposites have selective antitumor activity effects on FR-overexpressing tumors and no adverse effects on normal tissues and organs. In conclusion, the Au–BSA–DOX–FA nanocomposite exhibits selective targeting activity, X-ray attenuation activity and pH-sensitive drug release activity. Therefore, it can enhance CT imaging and improve the targeting therapeutic efficacy of FR-overexpressing gastric cancers. Our findings suggest that Au–BSA–DOX–FA nanocomposite is a novel drug delivery carrier and a promising candidate for cancer theranostic applications.

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“…1b). Moreover, aryl iodides are useful in their own right and have already found wide application in the medical research field, for example, in hypothyroidism treatment, single-photon-emission computed tomography and preclinical X-ray imaging [4][5][6][7] . The existence of different radioactive iodine isotopes ( 131 I, 125 I, 123 I) also makes it possible to label the same target agent with different isotopes, which provides additional flexibility in pharmacokinetic studies.…”

Section: Introductionmentioning

confidence: 99%

Photo-induced iodination of aryl halides under very mild conditions

Liu

et al. 2016

Nat Protoc

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Aryl iodides are important precursors in synthetic chemistry that form carbon–carbon and carbon–heteroatom bonds. Most methods use transition-metal catalysts, which need to be scrupulously removed before the compounds can be used in the pharmaceutical and electronics industries, where only parts-per-million levels of transition metals are allowed. The aromatic Finkelstein iodination reaction is a powerful method of preparing valuable aryl iodides from cheap but less reactive aryl bromides and chlorides. This protocol describes a transition metal–free method for a photo-induced aromatic Finkelstein iodination reaction that is performed at room temperature (20 °C). With common aromatic bromides and sodium iodide (NaI) as the starting materials, as well as a catalytic amount of I2 as an additive, the corresponding aromatic iodides can be synthesized in yields ranging from 56 to 93% under UV light irradiation in the absence of any metal catalysts. Various functional groups such as nitrile, ester and amino can be tolerated, which will facilitate the further functionalization of the aromatic iodides. The procedure normally requires 38–40 h to complete

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Iodinated blood pool contrast media for preclinical X-ray imaging applications – A review

Cited by 232 publications

References 246 publications

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

pH-sensitive Au–BSA–DOX–FA nanocomposites for combined CT imaging and targeted drug delivery

Photo-induced iodination of aryl halides under very mild conditions

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Iodinated blood pool contrast media for preclinical X-ray imaging applications – A review

Cited by 232 publications

References 246 publications

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

pH-sensitive Au&ndash;BSA&ndash;DOX&ndash;FA nanocomposites for combined CT imaging and targeted drug delivery

Photo-induced iodination of aryl halides under very mild conditions

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Product

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pH-sensitive Au–BSA–DOX–FA nanocomposites for combined CT imaging and targeted drug delivery