Iodide Mumps after Intravascular Administration of a Nonionic Contrast Medium

Christensen, Jared D.

doi:10.1177/028418519503600115

Cited by 36 publications

(19 citation statements)

References 20 publications

(21 reference statements)

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“…20) Contrast media may also induce so-called iodide mumps, characterized by swelling of submandibular, sublingual or parotid glands and/or sialadenitis. 21,22) In rats, sodium iodide induces inflammatory lesions and squamous metaplasia of ducts in the sub-mandibular gland 23) that are in line with those seen in the present study. Moreover, treatment with iodinated glycerol is associated with focal atrophy and squamous metaplasia of the salivary glands.…”

supporting

confidence: 90%

Induction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide

Takegawa

Mitsumori

Oda

et al. 1998

Japanese Journal of Cancer Research

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In a 2-year carcinogenicity study of potassium iodide (KI) in F344/DuCrj rats, squamous cell carcinomas (SCCs) were observed in the salivary glands of 4/40 males and 3/40 females receiving 1000 ppm KI in the drinking water. Ductular proliferation with lobular atrophy was observed at high incidence in the submandibular glands of the high-dose animals, and squamous metaplasia was frequently evident within the proliferative ductules and the larger interlobular ducts. A transition from metaplasia to SCC was apparent. The results suggest that squamous metaplasia in proliferative ductules, occurring secondarily to lobular impairment induced by KI, may develop into SCCs via a non-genotoxic, proliferation-dependent mechanism.

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supporting

confidence: 90%

Induction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide

Takegawa

Mitsumori

Oda

et al. 1998

Japanese Journal of Cancer Research

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“…Iodide mumps can occur after the administration of any type of iodinated contrast agent, including both ionic and nonionic media. 12 , 17 , 18 , 33 , 34 Eighteen of the 36 patients had received ionic contrast media, 15 had received nonionic contrast media, and the type of media was not specified in 3 cases. A low-osmolar nonionic contrast agent (ioversol) was used in our case.…”

Section: Discussionmentioning

confidence: 99%

Acute Submandibular Swelling Complicating Arteriography With Iodide Contrast

Zhang

et al. 2015

Medicine

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Iodide mumps is an uncommon condition induced by iodide-containing contrast. We present the first reported case of iodide mumps in mainland China, which occurred after carotid artery intervention.The patient, a 65-year-old Chinese male, had a history of dizziness, hypertension, diabetes, and right arm weakness. He had no history of allergies and had never previously received iodide-containing contrast. The patient's kidney function and other laboratory findings were normal. He underwent stenting of the left internal carotid artery (LICA) opening and received approximately 250 mL of a nonionic contrast agent (ioversol). Approximately 5 hours after angioplasty, bilateral local swellings were noted near the mandible; the masses were moderately firm and nontender.Iodide mumps was diagnosed in the patient. Intravenous dexamethasone (10 mg) was administered. The submandibular glands had shrunk by 11 hours after angioplasty, and they gradually became softer. The mandibular salivary glands had completely recovered by 5 days after surgery.Iodide mumps represents a rare late reaction to iodine-containing contrast media. This condition can occur in any patient receiving any iodinated contrast agent and may recur upon repeated exposure, but self-resolution can be expected within 2 weeks. All clinicians who use contrast media or iodide should be aware of this condition.

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“…Moreover, a large majority of the Na + /I − cotransporters are concentrated in the kidneys, and the remainder in the salivary, sweat, and lacrimal glands [7] . Thus, the risk of contrast-induced sialadenitis is presumed to increase with serum iodide levels and with existing renal dysfunction [8] . Indeed, in patients with end-stage renal function, emergent hemodialysis has shown to reduce the duration of the symptoms [9] .…”

Section: Discussionmentioning

confidence: 99%

Hyperacute unilateral contrast-induced parotiditis during cerebral angiography

Kim

Grossberg

Nogueira

et al. 2018

Radiology Case Reports

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An uncommon complication of iodinated contrast administration is the development of bilateral sialadenitis. We report a unique case of hyperacute unilateral parotiditis during diagnostic cerebral angiography of the external carotid artery, which mimicked possible iatrogenic vascular event associated with cerebral endovascular procedures. Discussion includes the differential diagnosis, diagnostic studies, and treatments for this unusual condition.

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Iodide Mumps after Intravascular Administration of a Nonionic Contrast Medium

Cited by 36 publications

References 20 publications

Induction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide

Induction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide

Acute Submandibular Swelling Complicating Arteriography With Iodide Contrast

Hyperacute unilateral contrast-induced parotiditis during cerebral angiography

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