Hyperacute unilateral contrast-induced parotiditis during cerebral angiography

Kim, Song; Grossberg, Jonathan A; Nogueira, Raul G; Haussen, Diogo C

doi:10.1016/j.radcr.2017.09.020

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…Originally thought to be IgE-mediated, the swelling symptoms have been mistakenly attributed to angioedema or anaphylaxis (19). While the exact pathogenesis of iodine mumps is still unclear, the current understanding of the condition is a pseudoallergic reaction to contrast related to accumulation of iodine in the salivary gland ducts (28,38,64). The concentration of iodine in the salivary gland has been measured up to 100 times plasma level and may be exacerbated by renal injury causing impaired iodine excretion (3,64).…”

Section: Introductionmentioning

confidence: 99%

Characterization of Iodide-induced Sialadenitis: Meta-analysis of the Published Case Reports in the Medical Literature

et al. 2020

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To evaluate the patient presentation of postcontrast sialadenitis and factors associated with its duration of symptoms through meta-analysis of case reports. Background: Acute iodide sialadenitis, or "iodide mumps," is a rare adverse reaction to iodinated contrast causing salivary gland swelling. The condition may be underdiagnosed, with researchers postulating that its true incidence may be close to 1-2%. Methods and Materials: This study was a meta-analysis performed using PRISMA Reporting Standards. A literature search with no language restriction was performed of the Medline database, primarily through PubMed, using keywords: "iodide mumps," "iodide sialadenitis," "sialadenitis," "salivary enlargement," "contrast reaction," "parotid swelling," and "submandibular swelling." Matching case reports and case series were reviewed, and data regarding the subjects' demographics, renal function, contrast administration, and symptoms were extracted. Uni-and multivariate linear regression analyses were applied to assess the predicting factors of a prolonged symptoms duration. Results: Sixty-five case reports and case series were identified, with 77 cases of iodide-induced sialadenitis. Two cases were unpublished and from the author's institution. Reported subjects' median age was 63 years, and 61% (47/77) were males. Median time to onset was 16 hours, and symptoms resolved in a median of 3 days after the initial onset. Twenty-seven subjects (35%, 27/77) were reported to have an impaired renal function at baseline. Administration of nonionic, low osmolarity contrast medium was reported most frequently (53%, 41/77). There was no difference in resolution of symptoms among subjects with impaired versus normal renal function. Symptoms were resolved in all cases over a median of 3 days with no statistically significant difference between those who received therapeutic intervention and those who did not (p = 0.430). Older age and longer time to onset were significantly associated with longer duration of symptoms in both uni-and multivariate linear regression models, and presence of tenderness demonstrated statistical significance associated with longer duration of symptoms in the univariate model. Conclusion: Postcontrast sialadenitis is a rare reaction to iodinated contrast media. Older age and a longer time to onset of symptoms are associated with longer duration of symptoms.

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Section: Introductionmentioning

confidence: 99%

Characterization of Iodide-induced Sialadenitis: Meta-analysis of the Published Case Reports in the Medical Literature

et al. 2020

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“…CIS manifests as a painless bilateral symmetric salivary gland edema probably due to the accumulation of iodine within the glands, causing a local inflammatory process [2] . It can appear within minutes after ICM administration of until 5 days [3 , 4] . Since the first case described in 1956 by J. Miller et al.…”

Section: Introductionmentioning

confidence: 99%

Recurrent neck swelling after iodinated contrast media administration

Cunha

Maganinho

Marques

et al. 2021

Radiology Case Reports

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A 74-year-old male with an abdominal aortic aneurism reported 2 episodes of neck swelling 16 hours after an abdominal CT with iodinated contrast media that reappeared in a subsequent CT, although the use of pre-medication. The tests used to exclude the hypersensitivity hypothesis where negative and once a new CT where needed we decided to do it with close monitoring. We performed a facial picture and cervical ultrasound exam before and 24 hours after the exam. The neck swelling and the ultrasound findings 24 hours after the CT made the diagnosis of contrast induced sialoadenitis possible. Contrast induced sialadentis is an uncommon adverse reaction to iodinated contrast media. As it presents with neck swelling it is important to exclude a hypersensitivity reaction because it’s further limitations and make a differential diagnosis.

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Iohexol

2018

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Hyperacute unilateral contrast-induced parotiditis during cerebral angiography

Cited by 3 publications

References 12 publications

Characterization of Iodide-induced Sialadenitis: Meta-analysis of the Published Case Reports in the Medical Literature

Characterization of Iodide-induced Sialadenitis: Meta-analysis of the Published Case Reports in the Medical Literature

Recurrent neck swelling after iodinated contrast media administration

Iohexol

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