Involvement of the pineal gland and melatonin in murine analgesia

Lakin, Mervyn; Miller, Claramae H.; Stott, M. L.; Winters, Wendell D.

doi:10.1016/0024-3205(81)90710-4

Cited by 153 publications

(84 citation statements)

References 10 publications

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“…In addition, melatonin improves wound healing in pinealectomized animals [38]. Melatonin also reduces pain in rodents [39,40,41,42] due to a direct action on the opiatergic centers in the central nervous system [20,40]. In the present study, the normal daily variation in melatonin was restored 1 day after the surgery, suggesting that this is the time required to initiate the healing processes that follows the surgery.…”

Section: Discussionsupporting

confidence: 53%

The Concept of the Immune-Pineal Axis Tested in Patients Undergoing an Abdominal Hysterectomy

Tatsch-Dias¹,

Levandovski

Souza³

et al. 2013

Neuroimmunomodulation

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Objective: Activation of the immune-pineal axis induces a transient reduction in nocturnal melatonin in the plasma during the proinflammatory phase of an innate immune response to allow the proper migration of leukocytes to the lesion site. This transient reduction should be regulated by inflammatory mediators, which are responsible for the fine-tuning of the process. In the present study, we measured the pre- and postoperative serum concentrations of melatonin, tumor necrosis factor (TNF) and cortisol in women who underwent an elective hysterectomy and correlated the variation in melatonin with postoperative pain. Methods: We evaluated 12 women who had an abdominal hysterectomy. Blood was collected at 10.00 and 22.00 h 1 week and 1 day before the surgery, on the 1st and 2nd days after the surgery and at 22.00 h on the day of the surgery. Results: On the night after the surgery, there was no melatonin detected at 22.00 h. High TNF levels were accompanied by a lower nocturnal melatonin output, higher postoperative pain according to a visual analog scale and the request of higher doses of analgesics. In addition, low cortisol levels were accompanied by a lower nocturnal melatonin output. Conclusion: Our results confirm that the same antagonistic pattern between TNF and glucocorticoids observed in cultured pineal glands also occurs in humans. This integrative pattern suggests that the cross talk between the immune and endocrine system orchestrates longitudinal changes in pineal activity, reinforcing the hypothesis of an immune-pineal axis.

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Section: Discussionsupporting

confidence: 53%

The Concept of the Immune-Pineal Axis Tested in Patients Undergoing an Abdominal Hysterectomy

Tatsch-Dias¹,

Levandovski

Souza³

et al. 2013

Neuroimmunomodulation

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“…Tliis suggests that exogenous melatonin had either to summate with endogenous mela tonin or to play its role via the mediation of the pineal gland. In the last case, one can speculate that melatonin releases some other active compounds from the pineal or, and more probably, that it stimulates and/or resyn chronizes the rhythm of pineal secretory activity, as it was recently demonstrated in intact adult rats [41], Recent experimental data demonstrate that pineal gland and melatonin exert important effects on opioid functions [42,43]. Px eliminates the daily rhythm of pain sensitivity in mice, while naloxone reverses the analgesic response induced by melatonin administration [42], Fur thermore, the pineal gland is known to synchronize sev eral endogenous circadian rhythms with the LD cycle [16,368 Trentini/Genazzani/Criscuolo/Petraglia/ Melatonin, Opioids and LH in Aging De Gaetani/Ficarra/Bidzinska/Migaldi/ Genazzani 44,45], including that of its own secretory activity [41], via the translation of neural impulses generated by changing photoperiod to melatonin release.…”

Section: Discussionmentioning

confidence: 99%

Melatonin Treatment Delays Reproductive Aging of Female Rat via the Opiatergic System

et al. 1992

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In female rat age-related reproductive decline is accompanied by progressive impairment of the neuroendocrine mechanisms that regulate LH secretion. The biosynthetic activity of the pineal gland is markedly depressed and the nocturnal secretion of melatonin decreases significantly. The aim of the present study was to evaluate whether the nocturnal administration of melatonin via the drinking water (0.4 µg/ml) throughout the course of aging from 14 to 24 months of age could (1) influence the age-related changes that occur in basal serum levels of LH and in the LH response to GnRH or to naloxone stimulation at 16, 18 and 20 months of age, and (2) delay the onset of the postreproductive constant estrous-anovulatory state as evaluated by the daily recording of vaginal smears and by occurrence of polyfollicular ovaries at 24 months of age. Our results demonstrate that melatonin replacement delays the increase in LH serum levels and the decrease in LH response to GnRH that occur in 18-month-old control animals. Furthermore, they show that melatonin treatment prevents the loss of LH response to naloxone manifested in control rats between 16 and 20 months of age. Melatonin also appears to prevent the progressive increase in the monthly occurrence of estrus phases as well as to decrease the number of rats with polyfollicular ovaries at 24 months of age in comparison to control animals. These results suggest that the age-related decrease in circulating melatonin during the night may contribute to the reproductive decline of aging, and that this effect may involve the central opioid system.

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“…In the early 1980s, scientists found that information derived from environmental light exposure affected pain sensitivity via the pineal gland hormone melatonin. 51 There is an increasing number of recent studies on the effects of melatonin on pain.…”

Section: Melatoninmentioning

confidence: 99%

Hormones in pain modulation and their clinical implications for pain control: a critical review

Chen¹,

Zhang²,

Wang³

2016

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Recently, more and more studies have found that pain generation, transmission and modulation are under hormonal regulation. Indeed, hormonal dysregulation is a common component of chronic pain syndromes. Studies have attempted to determine whether the relationship between the pain and its perception and hormones is a causative relationship and how these processes interrelate. This review summarizes and analyzes the current experimental data and provides an overview of the studies addressing these questions. The relationship between pain perception and endocrine effects suggests that hormones can be used as important biomarkers of chronic pain syndromes and/or be developed into therapeutic agents in the fight against pain.

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Involvement of the pineal gland and melatonin in murine analgesia

Cited by 153 publications

References 10 publications

The Concept of the Immune-Pineal Axis Tested in Patients Undergoing an Abdominal Hysterectomy

The Concept of the Immune-Pineal Axis Tested in Patients Undergoing an Abdominal Hysterectomy

Melatonin Treatment Delays Reproductive Aging of Female Rat via the Opiatergic System

Hormones in pain modulation and their clinical implications for pain control: a critical review

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