Involvement of Right Ventricle in Left Ventricular Hypertrophic Cardiomyopathy: Analysis by Pulsed Doppler Tissue Imaging

Severino, Sergio; Caso, Pio; Cicala, Silvana; Galderisi, Maurizio; Simone, Luigi De; D’Andrea, Antonello; D’Errico, Arcangelo; Mininni, N

doi:10.1053/euje.2000.0043

Cited by 68 publications

(55 citation statements)

References 15 publications

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“…These studies also demonstrated that RV and interventricular septum hypertrophy seem to be the major factors influencing the RV functions in systemic hypertension [33, 34]. Similarly elevated LV filling pressure can translate to elevated RV pressure and hence RV abnormalities.…”

Section: Discussionmentioning

confidence: 97%

Evaluation of Right Ventricular Systolic and Diastolic Function in Patients with Newly Diagnosed Obstructive Sleep Apnea Syndrome without Hypertension

et al. 2009

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Objectives: We investigated right ventricular (RV) structural and functional cardiac alterations in obstructive sleep apnea (OSA) independent of systemic hypertension and their correlation to the severity of OSA. Methods: Forty-one moderate-to-severe OSA but otherwise healthy patients and 30 body mass index-matched control subjects were included. All subjects underwent 24-hour ambulatory blood pressure monitoring, standard and tissue Doppler imaging of the RV. Results: The OSA group had increased RV wall thickness, impaired right ventricular outflow tract fractional shortening (RVOT fs), tricuspid annular plane systolic excursion (TAPSE), RV myocardial performance index (MPI) and RV myocardial acceleration during isovolumic contraction (IVA) (p < 0.001). Apnea hypopnea index (AHI) and mean pulmonary artery (PA) pressure were correlated with all these indices (p < 0.01 for all). RV free wall thickness (p < 0.001) and IVA (p = 0.006) remained significant predictors of AHI after adjusting for age, body mass index, mean PA pressure, RVOT fs, TAPSE and MPI in a multiple stepwise linear regression model. Conclusions: OSA is associated with impaired RV function despite normal systemic blood pressures. The level of RV dysfunction has a direct relationship with the severity of OSA. RV free wall thickness and IVA are independent predictors of AHI in uncomplicated OSA patients.

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Section: Discussionmentioning

confidence: 97%

Evaluation of Right Ventricular Systolic and Diastolic Function in Patients with Newly Diagnosed Obstructive Sleep Apnea Syndrome without Hypertension

et al. 2009

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“…These velocities have also been related with a stage of cardiac failure in heart transplant patients [17]. The right ventricular relaxation time and the early/late diastolic velocity ratio have been related to the involvement of the right ventricle in left ventricular hypertrophic cardiomyopathy and hypertension [18, 19]. …”

Section: Discussionmentioning

confidence: 99%

Evaluation of Right Ventricular Function in Patients with Thyroid Dysfunction

Arınç

Gunduz²,

Tamer³

et al. 2006

Cardiology

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Background: Thyroid gland dysfunction affects the structure and function of the heart. Tissue Doppler echocardiography is a new technique, and it has been used frequently in the evaluation of ventricular function. In the present study, right ventricular function was assessed in patients with overt or subclinical hypothyroidism and hyperthyroidism and in healthy subjects using the tissue Doppler method, and results were compared. Patients and Methods: 20 healthy subjects and 63 patients diagnosed with overt and subclinical hypothyroidism and hyperthyroidism were included in the study. Annular and myocardial systolic peak velocities, early and late diastolic peak velocities, precontraction, total contraction and relaxation times of the right ventricle were recorded by tissue Doppler echocardiography. The results of the patients were compared to those of the controls. Results: Myocardial systolic velocity was significantly higher in patients with hyperthyroidism. Annular and myocardial late diastolic velocities were found to be significantly lower in patients with overt hypothyroidism. Annular precontraction time was increased in patients with overt and subclinical hypothyroidism. Myocardial precontraction time was decreased in patients with hyperthyroidism, and increased in patients with overt hypothyroidism patients. Annular relaxation time was increased in patients with overt hypothyroidism. Conclusions: Right ventricular function is affected in patients with thyroid diseases. The tissue Doppler technique is a suitable tool to detect impairments in right ventricular function. There is a significant correlation between serum thyroid hormone levels and right ventricular velocities and time intervals.

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“…Pressões diastólicas aumentadas são necessárias devido à rigidez e à menor distensibilidade ventricular (Severino et al 2000, Chetboul et al 2006b, Gundler Tidholm & Haggstrõm 2008. O ventrículo esquerdo, mais rígido, requer pressões de enchimento maiores e, consequentemente, as pressões diastólicas atriais e ventriculares aumentam (Kato et al 2007, Ware 2007, Koffas et al 2008.…”

Section: Introductionunclassified

Avaliação da função diastólica por meio de Doppler tecidual pulsado e colorido em gatos da raça Maine Coon geneticamente testados para a mutação no gene MyBPC-A31P

et al. 2014

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A cardiomiopatia hipertrófica (CMH) é a principal cardiopatia dos felinos e é caracterizada por hipertrofia miocárdica concêntrica, sem dilatação ventricular. Disfunções miocárdicas ocorrem em gatos com CMH, mas pouco se conhece a respeito destas alterações nos estágios iniciais da afecção. Em gatos da raça Maine Coon, a mutação no gene MyBPC-A31P está relacionada com a CMH de origem familial, porém, a correlação exata entre o genótipo e o fenótipo ainda é inconclusiva. A ecocardiografia tecidual é uma modalidade não invasiva que permite avaliação da função miocárdica e é mais sensível que a ecocardiografia convencional. Para avaliar as funções sistólica e diastólica, antes ou após a ocorrência de hipertrofia ventricular, gatos da raça Maine Coon (n=57), geneticamente testados para a mutação, foram avaliados por meio de ecocardiografias convencional e tecidual (nas modalidades Doppler tecidual pulsado e Doppler tecidual colorido). Posteriormente, foram fenotipicamente classificados em: normais (n=45), suspeitos (n=7) e acometidos pela CMH (n=5); e genotipicamente classificados em: negativos (n=28), heterozigotos (n=26) e homozigotos para a mutação (n=3). Valores de velocidades miocárdicas (Doppler tecidual pulsado e colorido) medidos na região basal e média do septo interventricular (SIV), da parede livre do ventrículo esquerdo (PVE), da parede anterior do ventrículo esquerdo (PAVE), da parede posterior do ventrículo esquerdo (PPVE) e do segmento radial da PVE, foram comparados nos diferentes grupos. Observou-se que as velocidades longitudinais Em (Doppler tecidual pulsado) na região média da PVE foram menores nos gatos com CMH quando comparados com suspeitos e normais. Os valores de Em/Am (Doppler tecidual colorido), na região basal do SIV, foram inferiores nos gatos com CMH quando comparados com suspeitos e normais. A relação E/Em (Doppler tecidual colorido), na região basal do SIV, foi maior nos gatos com CMH em relação aos suspeitos e normais, enquanto que os valores de Sm (Doppler tecidual colorido), em região basal da PVE, foram menores nos gatos heterozigotos quando comparados com os negativos, ambos sem hipertrofia ventricular. Observou-se correlação positiva entre a ocorrência de fusão das ondas Em e Am e a frequência cardíaca, assim como correlação positiva entre valores de Sm e Em e a frequência cardíaca (Doppler tecidual pulsado e colorido). A ecocardiografia tecidual é uma nova modalidade ecocardiográfica reprodutível em gatos que, isoladamente, não permite diferenciar gatos portadores da mutação antes do desenvolvimento de hipertrofia ventricular. Apresenta utilidade como auxílio no diagnóstico em fases iniciais, mas, apesar da expectativa para a identificação precoce de indivíduos portadores da CMH, ainda há necessidade de estudos mais extensos e com maior número de indivíduos.

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Involvement of Right Ventricle in Left Ventricular Hypertrophic Cardiomyopathy: Analysis by Pulsed Doppler Tissue Imaging

Abstract: This study shows the usefulness of pulsed Doppler tissue imaging to detect impairment of right ventricular myocardial function and to provide evidence about ventricular interaction in forms of hypertrophic cardiomyopathy which involve interventricular septum.

Cited by 68 publications

References 15 publications

Evaluation of Right Ventricular Systolic and Diastolic Function in Patients with Newly Diagnosed Obstructive Sleep Apnea Syndrome without Hypertension

Evaluation of Right Ventricular Systolic and Diastolic Function in Patients with Newly Diagnosed Obstructive Sleep Apnea Syndrome without Hypertension

Evaluation of Right Ventricular Function in Patients with Thyroid Dysfunction

Avaliação da função diastólica por meio de Doppler tecidual pulsado e colorido em gatos da raça Maine Coon geneticamente testados para a mutação no gene MyBPC-A31P

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