Involvement of planned cell death of necroptosis in cancer treatment by nanomaterials: Recent advances and future perspectives

Sharifi, Majid; Hosseinali, Sara Haji; Saboury, Ali Akbar; Szegezdi, Éva; Falahati, Mojtaba

doi:10.1016/j.jconrel.2019.02.007

Cited by 53 publications

(23 citation statements)

References 144 publications

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“…On the other hand, Co 3 O 4 NPs induced apoptosis in K562 cells based on the increased level of intracellular ROS, which is a crucial signal in the induction of apoptosis. 26 In addition, our results confirmed that Co 3 O 4 NPs induced apoptosis in K562 cells via both intrinsic and extrinsic pathways by increasing the expression levels of Bax/Bcl-2 mRNA and activation of caspase-9, −8, and −3. In agreement with our results, Khan, Ansari, Khan, Ahmad, Al-Obaid, Al-Kattan 52 revealed that the addition of Co 3 O 4 NPs increased the expression levels of Bax/Bcl-2 mRNA in cancerous cells, which eventually induced apoptotic cell death.…”

Section: Discussionsupporting

confidence: 76%

“…This property is due to the extremely small size and surface-tovolume ratio of these particles. 26 Therefore, due to the high antibacterial activity of the NPs, they can be used to enhance the safety of food packaging 27,28 as well as in the development of a new generation of antibacterial drugs. 29,30 In this area, cobalt oxide (Co 3 O 4 ) NPs have shown outstanding features because of their promising physicochemical properties like the anisotropy constant, coercivity and Curie temperature, saturation magnetization and ease of fabrication.…”

Section: Introductionmentioning

confidence: 99%

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<p>Exploring the Interaction of Cobalt Oxide Nanoparticles with Albumin, Leukemia Cancer Cells and Pathogenic Bacterial by Multispectroscopic, Docking, Cellular and Antibacterial Approaches</p>

Arsalan

Kashi

Hasan

et al. 2020

IJN

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The interaction of NPs with biological systems may reveal useful details about their pharmacodynamic, anticancer and antibacterial effects. Methods: Herein, the interaction of as-synthesized Co 3 O 4 NPs with HSA was explored by different kinds of fluorescence and CD spectroscopic methods, as well as molecular docking studies. Also, the anticancer effect of Co 3 O 4 NPs against leukemia K562 cells was investigated by MTT, LDH, caspase, real-time PCR, ROS, cell cycle, and apoptosis assays. Afterwards, the antibacterial effects of Co 3 O 4 NPs against three pathogenic bacteria were disclosed by antibacterial assays. Results: Different characterization methods such as TEM, DLS, zeta potential and XRD studies proved that fabricated Co 3 O 4 NPs by sol-gel method have a diameter of around 50 nm, hydrodynamic radius of 177 nm with a charge distribution of −33.04 mV and a welldefined crystalline phase. Intrinsic, extrinsic, and synchronous fluorescence as well as CD studies, respectively, showed that the HSA undergoes some fluorescence quenching, minor conformational changes, microenvironmental changes as well as no structural changes in the secondary structure, after interaction with Co 3 O 4 NPs. Molecular docking results also verified that the spherical clusters with a dimension of 1.5 nm exhibit the most binding energy with HSA molecules. Anticancer assays demonstrated that Co 3 O 4 NPs can selectively lead to the reduction of K562 cell viability through the cell membrane damage, activation of caspase-9,-8 and-3, elevation of Bax/Bcl-2 mRNA ratio, ROS production, cell cycle arrest, and apoptosis. Finally, antibacterial assays disclosed that Co 3 O 4 NPs can stimulate a promising antibacterial effect against pathogenic bacteria. Conclusion: In general, these observations can provide useful information for the early stages of nanomaterial applications in therapeutic platforms.

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Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

<p>Exploring the Interaction of Cobalt Oxide Nanoparticles with Albumin, Leukemia Cancer Cells and Pathogenic Bacterial by Multispectroscopic, Docking, Cellular and Antibacterial Approaches</p>

Arsalan

Kashi

Hasan

et al. 2020

IJN

Self Cite

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“…In this regard, it has been attempted to utilize nanomaterials to develop theranostic platforms for the treatment of breast cancer 2 . However, working in various therapeutic areas based on nano-based platforms is a complex and difficult process due to the limited colloidal stability and combined-modality therapy, toxicity, and complex mechanism of NPs in the biological systems [3][4][5] . A better understanding of breast cancer microenvironment, cancer drug resistance, control of drug clearance and drug delivery along with auxiliary therapeutic platforms such as chemotherapy, MF therpay, PTT or their combination have been facilitated the treatment of breast cancer [6][7][8] .…”

mentioning

confidence: 99%

Combined chemo-magnetic field-photothermal breast cancer therapy based on porous magnetite nanospheres

Sharifi

Hasan

Nanakali

et al. 2020

Sci Rep

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The efficacy of different modalities of treating breast cancer is inhibited by several limitations such as off-targeted drug distribution, rapid drug clearance, and drug resistance. To overcome these limitations, we developed Lf-Doxo-PMNSs for combined chemo-MF-PTT. The PMNSs were synthesized by hydrothermal method and their physicochemical properties were examined by FE-SEM, TEM, DLS, TGA, XRD investigations. The cytotoxicity of as-synthesized NPs against 4T1 cells was carried out by MTT and flow cytometry assays. Afterwards, the anti-cancer activities of as-synthesized Lf-Doxo-PMNSs on the tumor status, drug distribution and apoptosis mechanism were evaluated. The anti-cancer assays showed that Lf-Doxo-PMNSs significantly suppressed the cancer cell proliferation and tumor weight by prolonging drug availability and potential drug loading in tumor cells; whereas they showed a minimum cytotoxicity against non-cancerous cells. Likewise, combined chemo-MF-PTT using Lf-Doxo-PMNSs displayed the highest anti-cancer activity followed by combined chemo-PTT and combined chemo-MF therapy based on altering the apoptosis mechanism. Therefore, these results showed that combined chemo-MF-PTT based on Lf-Doxo-PMNSs can be used as a promising therapeutic platform with potential targeted drug delivery and high loading capacity features as well as reducing cancer drug resistance.

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“…Other hypotheses could be derived when looking into the tumor immunology pathway, where the concurrent activation ofdifferent known regulated cell death pathways (RCD) as an alternative route to overcome cancer cell resistance phenomena. This should be looked into as an option for cell death in further studies [58][59][60]. The observations that we made clearly indicated that HepG2 cell death after nanocomposite treatment was associated with the upregulations of p53 and p21 gene expressions, assisted by the upregulations of BAD, BAX, cytochrome c and caspase-3 cascade reactions, which lead to cell death by the apoptosis mechanism.…”

Section: Discussionmentioning

confidence: 69%

Anticancer Molecular Mechanism of Protocatechuic Acid Loaded on Folate Coated Functionalized Graphene Oxide Nanocomposite Delivery System in Human Hepatocellular Carcinoma

et al. 2021

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Liver cancer is listed as the fifth-ranked cancer, responsible for 9.1% of all cancer deaths globally due to its assertive nature and poor survival rate. To overcome this obstacle, efforts have been made to ensure effective cancer therapy via nanotechnology utilization. Recent studies have shown that functionalized graphene oxide (GO)-loaded protocatechuic acid has shown some anticancer activities in both passive and active targeting. The nanocomposites’ physicochemical characterizations were conducted. A lactate dehydrogenase experiment was conducted to estimate the severity of cell damage. Subsequently, a clonogenic assay was carried out to examine the colony-forming ability during long-term exposure of the nanocomposites. The Annexin V/ propidium iodide analysis showed that nanocomposites induced late apoptosis in HepG2 cells. Following the intervention of nanocomposites, cell cycle arrest was ascertained at G2/M phase. There was depolarization of mitochondrial membrane potential and an upregulation of reactive oxygen species when HepG2 cells were induced by nanocomposites. Finally, the proteomic profiling array and quantitative reverse transcription polymerase chain reaction revealed the expression of pro-apoptotic and anti-apoptotic proteins induced by graphene oxide conjugated PEG loaded with protocatechuic acid drug folic acid coated nanocomposite (GOP–PCA–FA) in HepG2 cells. In conclusion, GOP–PCA–FA nanocomposites treated HepG2 cells exhibited significant anticancer activities with less toxicity compared to pristine protocatechuic acid and GOP–PCA nanocomposites, due to the utilization of a folic acid-targeting nanodrug delivery system.

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Involvement of planned cell death of necroptosis in cancer treatment by nanomaterials: Recent advances and future perspectives

Cited by 53 publications

References 144 publications

<p>Exploring the Interaction of Cobalt Oxide Nanoparticles with Albumin, Leukemia Cancer Cells and Pathogenic Bacterial by Multispectroscopic, Docking, Cellular and Antibacterial Approaches</p>

<p>Exploring the Interaction of Cobalt Oxide Nanoparticles with Albumin, Leukemia Cancer Cells and Pathogenic Bacterial by Multispectroscopic, Docking, Cellular and Antibacterial Approaches</p>

Combined chemo-magnetic field-photothermal breast cancer therapy based on porous magnetite nanospheres

Anticancer Molecular Mechanism of Protocatechuic Acid Loaded on Folate Coated Functionalized Graphene Oxide Nanocomposite Delivery System in Human Hepatocellular Carcinoma

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