Involvement of opioidergic system of the ventral hippocampus, the nucleus accumbens or the central amygdala in anxiety-related behavior

Zarrindast, Mohammad‐Reza; Babapoor-Farrokhran, Sahand; Babapoor-Farrokhran, Savalan; Rezayof, Ameneh

doi:10.1016/j.lfs.2008.03.020

Cited by 71 publications

(40 citation statements)

References 66 publications

(81 reference statements)

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“…The role of dopamine in avoidance behavior is consistent with the responsivity of dopaminergic neurons to both fearful and rewarding stimuli (Brischoux et al, 2009;Matsumoto and Hikosaka, 2009), and the anxiogenic effect of cocaine, a dopamine reuptake inhibitor, in the NAcc (David et al, 2001). Moreover, work in non-human primates and rodents suggest that the NAcc may be responsible for the etiology and persistence of pathological avoidance behavior in anxiety disorders (Kalin et al, 2005;Zarrindast et al, 2008).…”

Section: Introductionsupporting

confidence: 58%

Avoidance of harm and anxiety: A role for the nucleus accumbens

2012

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Section: Introductionsupporting

confidence: 58%

Avoidance of harm and anxiety: A role for the nucleus accumbens

2012

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“…As it was previously said, NAS has been early involved in anxiety processes by us and another group [37,44,45], and after it, an important number of laboratories are showing additional evidences on the role of NAS in anxiety, citing our findings [12,15,16,43,65]. All these studies give support to a previous study using immunohistochemical staining for fos-like activity, mapping functional activation of discrete brain areas induced by anxiogenic situations.…”

supporting

confidence: 89%

Differential behavioral profile induced by the injection of dipotassium chlorazepate within brain areas that project to the nucleus accumbens septi

López

Caif

Fraile

et al. 2013

Pharmacological Reports

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Abstract:Background: The effect of the agonism on g-aminobutyric acid (GABA) receptors was studied within medial prefrontal cortex (mPFC), amygdala (AMY) and ventral hipocampus (VH) in the plus-maze test in male rats bilaterally cannulated. These structures send glutamatergic projections to the nucleus accumbens septi (NAS), in which interaction and integration between these afferent pathways has been described. In a previous study of our group, blockade of glutamatergic transmission within NAS induced an anxiolytic like effect. Methods: Three rat groups received either saline or dipotassium chlorazepate (1 or 2 µg/1 µl solution) 15 min before testing. Time spent in the open arms (TSOA), time per entry (TPE), extreme arrivals (EA), open and closed arms entries (OAE, CAE) and relationship between open-and closed-arms quotient (OCAQ) were recorded. Results: In the AMY injected group TSOA, OAE and EA were increased by the higher doses of dipotassium chlorazepate (p < 0.01). In the mPFC, TPE was decreased by both doses (p < 0.05). Injection within ventral hippocampus (VH) decreased TSOA, OAE and OCAQ with lower doses (p < 0.05). When the three studied saline groups were compared, TSOA, OAE, EA and OCAQ were enhanced in the VH group when compared to mPFC and AMY (p < 0.001). Insertion of inner canula (p < 0.001, p < 0.01, p < 0.01) and saline injection showed an increasing significant difference (p < 0.001 in all cases) with the action of guide cannula alone within VH in TSOA, OAE and EA. Conclusion: We conclude that the injection of dipotassium chlorazepate has a differential effect depending of the brain area, leading to facilitatory and inhibitory effects on anxiety processing.

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“…The LS, one of the nuclei included in the SBN, is connected with a number of limbic, diencephalic, and midbrain regions and plays a role in regulating the processes related to mood and motivation in vertebrates (32). It also has been implicated in the modulation of anxiety-like behavior via the histaminergic system (33).…”

Section: Discussionmentioning

confidence: 99%

Female genomic response to mate information

Desjardins

Klausner²,

Fernald³

2010

Proc. Natl. Acad. Sci. U.S.A.

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Females should be choosier than males about prospective mates because of the high costs of inappropriate mating decisions. Both theoretical and empirical studies have identified factors likely to influence female mate choices. However, male-male social interactions also can affect mating decisions, because information about a potential mate can trigger changes in female reproductive physiology. We asked how social information about a preferred male influenced neural activity in females, using immediate early gene (IEG) expression as a proxy for brain activity. A gravid female cichlid fish (Astatotilapia burtoni) chose between two socially equivalent males and then saw fights between these two males in which her preferred male either won or lost. We measured IEG expression levels in several brain nuclei including those in the vertebrate social behavior network (SBN), a collection of brain nuclei known to be important in social behavior. When the female saw her preferred male win a fight, SBN nuclei associated with reproduction were activated, but when she saw her preferred male lose a fight, the lateral septum, a nucleus associated with anxiety, was activated instead. Thus social information alone, independent of actual social interactions, activates specific brain regions that differ significantly depending on what the female sees. In female brains, reproductive centers are activated when she chooses a winner, and anxiety-like response centers are activated when she chooses a loser. These experiments assessing the role of mate-choice information on the brain using a paradigm of successive presentations of mate information suggest ways to understand the consequences of social information on animals using IEG expression. cellular homologue of fos | early growth response factor 1 | preoptic area | egr-1 F emales should be choosier about prospective mates than males, because bad mating decisions result in high costs (1). Consequently, studies on female assessment of male characteristics have produced conceptual, theoretical, and empirical information identifying key factors mediating female mate choice (for reviews, see refs. 2 and 3). Perhaps unsurprisingly, there is evidence that females also may use information about malemale social interactions in their mate-choice decisions (4-9), but little is known about how the brain responds to this kind of information.In many species, social information about potential mates can change female reproductive physiology and gene expression. For example, in zebra finch females (Taeniopygia guttata), expression of immediate early genes (IEGs) in telencephalic auditory areas increase in response to hearing a preferred male's song (10). Similarly, in female European starlings (Sturnus vulgaris), recent social interactions with males influence forebrain gene expression in response to mate-choice cues (11). This has also been shown in female swordtail fish (12). We predicted that social information also could affect nuclei in the social behavior network (SBN) initially identified by...

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Involvement of opioidergic system of the ventral hippocampus, the nucleus accumbens or the central amygdala in anxiety-related behavior

Cited by 71 publications

References 66 publications

Avoidance of harm and anxiety: A role for the nucleus accumbens

Avoidance of harm and anxiety: A role for the nucleus accumbens

Differential behavioral profile induced by the injection of dipotassium chlorazepate within brain areas that project to the nucleus accumbens septi

Female genomic response to mate information

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