Involvement of nitric oxide in itch-scratch response of NC mice

Tsukumo, Yukihito; Andoh, Tsugunobu; Yamaguchi, Tomomi; Nishimura, Hiroshi; Kuraishi, Yasushi

doi:10.1254/fpj.114.supplement_17

Cited by 12 publications

(9 citation statements)

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“…Given that NO is associated with itch (38), we next asked if administration of CQ would increase the level of nitrite, the end product of NO metabolism in the skin. Intradermal CQ (400 µg/site) induced scratching behavior with maximum scratching behavior at 10 to 20 min after injection (Fig.…”

Section: Resultsmentioning

confidence: 99%

Peripheral NMDA Receptor/NO System Blockage Inhibits Itch Responses Induced by Chloroquine in Mice

Haddadi

Foroutan²,

Ostadhadi³

et al. 2017

Acta Derm Venerol

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Intradermal administration of chloroquine (CQ) provokes scratching behavior in mice. Chloroquine-induced itch is histamine-independent and we have reported that the nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) pathway is involved in CQ-induced scratching behavior in mice. Previous studies have demonstrated that activation of N-methyl-d-aspartate receptors (NMDARs) induces NO production. Here we show that NMDAR antagonists significantly decrease CQ-induced scratching in mice while a non-effective dose of an NMDAR agonist potentiates the scratching behavior provoked by sub-effective doses of CQ. In contrast, combined pre-treatment with sub-effective doses of an NMDAR antagonist, MK-801, and the NO synthase inhibitor, L-N-nitro arginine methyl ester (L-NAME), decreases CQ-induced scratching behavior. While intradermal administration of CQ significantly increases the concentration of intradermal nitrite, the end product of NO metabolism, effective doses of intraperitoneal and intradermal MK-801 significantly decrease intradermal nitrite levels. Likewise, administration of an effective dose of L-NAME significantly decreases CQ-induced nitrite production. We conclude that the NMDA/NO pathway in the skin modulates CQ-induced scratching behavior.

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Section: Resultsmentioning

confidence: 99%

Peripheral NMDA Receptor/NO System Blockage Inhibits Itch Responses Induced by Chloroquine in Mice

Haddadi

Foroutan²,

Ostadhadi³

et al. 2017

Acta Derm Venerol

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“…33) These substances have been reported to be related to the induction and transmission of itch sensation. 20,34,35) The results of our experiments suggest that the active compounds of CS may be useful in the treatment of allergic disease, which is evoked by various mechanisms. At present, the depressive effects of these compounds on pruritus and dermatitis in atopic dermatitis model NC mice 36,37) are under investigation.…”

Section: Discussionmentioning

confidence: 79%

Antipruritic Effects of the Fruits of Chaenomeles sinensis

Oku

Ueda

Ishiguro

2003

Biological & Pharmaceutical Bulletin

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A 35% EtOH extract of the fruits of Chaenomeles sinensis, long utilized as a folk medicine for cough, significantly inhibited the pruritogenic agent compound 48/80 (COM)-induced scratching behavior in mice. Antipruritic activity-guided fractionation and purification yielded active quercetin, apigenin, and catechin derivatives, which exhibited significant inhibitory effects on COM-induced scratching behavior. To the best of our knowledge, apigenin (5), apigenin 7-glucronide (6), and apigenin 4'-methoxy-7-glucronide (acacetin 7-glucronide) (7) were isolated from the fruits of C. sinensis for the first time. The active fraction and these compounds also inhibited serotonin-, platelet activating factor-, and prostaglandin E(2)-induced scratching behavior, but did not inhibit histamine-induced scratching behavior or locomotive behavior. This study also showed that the fruits of C. sinensis could be used to treat allergic itching sensation.

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“…L-NAME was administered at 30 min and aminoguanidine/L-arginine at 60 min before serotonin injection. 12,13 Behavioural experiments…”

Section: Administration Proceduresmentioning

confidence: 99%