Antipruritic Effects of the Fruits of Chaenomeles sinensis

Abstract

A 35% EtOH extract of the fruits of Chaenomeles sinensis, long utilized as a folk medicine for cough, significantly inhibited the pruritogenic agent compound 48/80 (COM)-induced scratching behavior in mice. Antipruritic activity-guided fractionation and purification yielded active quercetin, apigenin, and catechin derivatives, which exhibited significant inhibitory effects on COM-induced scratching behavior. To the best of our knowledge, apigenin (5), apigenin 7-glucronide (6), and apigenin 4'-methoxy-7-glucronide (acacetin 7-glucronide) (7) were isolated from the fruits of C. sinensis for the first time. The active fraction and these compounds also inhibited serotonin-, platelet activating factor-, and prostaglandin E(2)-induced scratching behavior, but did not inhibit histamine-induced scratching behavior or locomotive behavior. This study also showed that the fruits of C. sinensis could be used to treat allergic itching sensation.

Inhibitory Effect of Chaenomeles sinensis Fruit on Amyloid β Protein (25-35)-Induced Neurotoxicity in Cultured Neurons and Memory Impairment in Mice

“…Flavonoid is one of the main phytochemical constituents in CSF and has been proven effective in preventing free radical-caused oxidative damage (Hamauzu et al, 2005;Zhou et al, 2007;Hu et al, 2008). Antibacterial, antiviral, antihemolytic and antipruritic activities have been reported as pharmacological activities of CSF (Osawa et al, 1997;Lee et al, 2002;Oku et al, 2003;Sawai et al, 2008). Anti-inflammatory effect of CSF was inferred based on the fact that it inhibited histamine release from rat mast cells and inhibited activation of hyaluronidase (Osawa et al, 1999(Osawa et al, , 2001).…”

Anti-Allergic Effect of a Hot-Water Extract of Quince (Cydonia oblonga)

“…In fact, many researchers have reported the distinct mechanism-based anti-allergic effect of fruits. [11][12][13] Given the effectiveness of quince HW-supplemented products against sore throats and coughs, quince HW can also be expected to have some sort of inhibitory effect against the type I allergic process.…”

Antianaphylactic and Antipruritic Effects of the Flowers of Impatiens textori MIQ.

“…12) IT (100 mg/kg) and saline (control group) were individually administered i.v. 1 h before the experiment.…”

“…Data of compound 1 cited from previous report. 12) active compounds are also being subjected to further study.…”