Involvement of nitric oxide and prostacyclin in the antihypertensive effect of low-molecular-weight procyanidin rich grape seed extract in male spontaneously hypertensive rats

Quiñones, Mar; Guerrero, Ligia; Fernández-Vallinas, Sandra; Pons, Zara; Arola, Lluı́s; Aleixandre, Amaya; Muguerza, Begoña

doi:10.1016/j.jff.2013.11.008

Cited by 35 publications

(16 citation statements)

References 28 publications

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“…The anti‐hypertensive effect of grape seed flavanols in SHR is an endothelium‐dependent effect mainly mediated by changes in endothelium‐derived factors such as nitric oxide and prostacyclin . Therefore, it would seem plausible that the endothelium of SHR presents higher concentrations of flavanol metabolites than that from healthy animals.…”

Section: Discussionmentioning

confidence: 99%

Rat health status affects bioavailability, target tissue levels, and bioactivity of grape seed flavanols

Margalef

Pons

Iglesias‐Carres

et al. 2016

Molecular Nutrition Food Res

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Section: Discussionmentioning

confidence: 99%

Rat health status affects bioavailability, target tissue levels, and bioactivity of grape seed flavanols

Margalef

Pons

Iglesias‐Carres

et al. 2016

Molecular Nutrition Food Res

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“…Moreover, several studies have reported the antihypertensive effects of GSPE and its underlying mechanism in hypertensive rats. For instance, Quiñones et al showed that GSPE increased prostaglandin F1α, a stable indicator of the production of prostaglandin I2, which is a vasodilator and inhibitor of platelet aggregation [60]. Liu et al showed that GSPE decreased the expression of both ET-1, a known contributor to vasoconstriction and vascular remodeling, and transforming growth factor-β, which stimulates ET-1 expression and renin release [61,62].…”

Section: Discussionmentioning

confidence: 99%

Effects of Grape Seed Proanthocyanidin Extract on Vascular Endothelial Function in Participants with Prehypertension: A Randomized, Double-Blind, Placebo-Controlled Study

et al. 2019

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This study aimed to investigate the effects of grape seed proanthocyanidin extract (GSPE) on blood pressure and vascular endothelial function in middle-aged Japanese adults with prehypertension. We conducted a randomized, double-blind, placebo-controlled study on 6 men and 24 women aged 40–64 years old. The participants were randomized to receive tablets containing either low-dose (200 mg/day) or high-dose (400 mg/day) GSPE, or placebo, for 12 weeks. Systolic and diastolic blood pressures (SBP and DBP, respectively), brachial flow-mediated dilation (FMD), and other cardiovascular parameters were measured before and after 4, 8, and 12 weeks of treatment. The mean SBP in the high-dose group significantly decreased by 13 mmHg after 12 weeks (P = 0.028), although FMD did not change. In an ad hoc analysis of non-smoking participants (n = 21), the mean SBP, DBP, stiffness parameter β, distensibility, incremental elastic modulus (Einc), and pulse wave velocity (PWV) also significantly improved in the high-dose group after 12 weeks. Changes in Einc and PWV from baseline to 12 weeks were significantly greater in the high-dose group than in the placebo group (Einc, P = 0.023; PWV, P = 0.03). GSPE consumption could help maintain vascular elasticity and normal blood pressure in this population.

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“…The antihypertensive properties of PAs are related to NOmediated vasodilation [61], angiotensin converting enzyme (ACE) inhibition [62] and a reduction in oxidative stress [59]. Nonetheless, the blood pressure-lowering effect of flavanols is mainly mediated through the NO pathway, and for grape seed PAs, it is also partially mediated by prostacyclin [63]. Other mechanisms that may be involved in the vasodilator effect of PAs include the inhibition of both phosphodiesterases (PDEs) 2 and 4, which catalyze the degradation of cAMP and cGMP, and PDE-5, which degrades cGMP [64].…”

Section: Pa Effects In Hypertensionmentioning

confidence: 99%

Proanthocyanidins in health and disease

et al. 2016

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Proanthocyanidins (PAs) are the most abundant flavonoids in the human diet. Several epidemiological studies connect PA consumption and health benefits and the designation of PAs as healthy compounds started at the early stages of the 20th century. The beneficial health properties of PAs are attributed to their conjugated and colonic metabolites. Therefore, gut microbial compositions can determine the effectiveness of PAs. Reciprocally, dietary polyphenols can act as prebiotics. Recently, it has also been described that PAs modulate the circadian rhythm. Biochemical and epigenetic mechanisms, including the modulation of microRNAs, allow PAs to modulate cell functionality. PA effects in metabolic diseases are also reviewed. © 2016 BioFactors, 42(1):5–12, 2016

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Involvement of nitric oxide and prostacyclin in the antihypertensive effect of low-molecular-weight procyanidin rich grape seed extract in male spontaneously hypertensive rats

Cited by 35 publications

References 28 publications

Rat health status affects bioavailability, target tissue levels, and bioactivity of grape seed flavanols

Rat health status affects bioavailability, target tissue levels, and bioactivity of grape seed flavanols

Effects of Grape Seed Proanthocyanidin Extract on Vascular Endothelial Function in Participants with Prehypertension: A Randomized, Double-Blind, Placebo-Controlled Study

Proanthocyanidins in health and disease

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