Involvement of nigrotecto-reticulospinal pathways in the iminodipropionitrile (IDPN) model of spasmodic dyskinesias: a 2-deoxy-d-[1-14C]glucose study in the rat

Cadet, Jean Lud; Puppa, Andrea Della; London, Edythe D.

doi:10.1016/0006-8993(89)90347-8

Cited by 11 publications

(2 citation statements)

References 48 publications

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“…The change in the substantia nigra correlation with the deep layers of the superior colliculus from positive to negative in the active dystonics compared to the quiet dystonics suggests that the nigrotectal projection is especially different from normal in the dystonic brain. Abnormal GU has been found in the substantia nigra and superior colliculus of the IDPN model of dyskinesia, also (Cadet et al, 1989). This is probably related to the head and neck movements of both models, and strongly implicates abnormalities in the nigrotectal system.…”

Section: Correlation Analysesmentioning

confidence: 82%

“…A possible explanation for the low overall GU in the dystonics and some littermates is that it reflects retarded development because normal younger animals than those used in this study show a low GU rate (McCann et al, 1986). Additional evidence which suggests that a global decrease might be an important feature of the dystonia comes from studies of adult rats with a mild dystonia syndrome caused by the drug iminidipropionitrile (IDPN) (Cadet et al, 1989). Of 49 regions measured following IDPN treatment, 47 showed decreases in GU, with 14 regions being significantly lower.…”

Section: Discussionmentioning

confidence: 99%

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Regional cerebral glucose utilization reveals widespread abnormalities in the motor system of the rat mutant dystonic

Brown

Lorden

1989

J. Neurosci.

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Rats with an inherited movement disorder (dystonic, dt), their phenotypically normal littermates, and normal unrelated controls were studied using a metabolic mapping technique, 2-deoxyglucose autoradiography. This approach was used to identify potential sites of abnormality underlying the movement disorder, as no morphological abnormalities using light and electron microscopic techniques have been identified in this mutation. There was a significant overall glucose utilization (GU) reduction in the dt rats and their littermate controls when they were at rest and not displaying abnormal movements. Conversion of GU values to standard scores showed abnormalities in dt compared with both control groups in the following areas: deep cerebellar nuclei, locus coeruleus, pontine gray, ventrolateral-ventromedial thalamic complex, nucleus of the third nerve, lateral habenula, and basolateral amygdala. Littermates were different from nonlittermates in several regions, including the dentate and red nuclei. A study of relative GU performed in animals displaying dystonic movements also showed abnormalities in the deep cerebellar nuclei and locus coeruleus, and in the red nucleus, external cuneate, and medial septum. Correlations computed for GU in pairs of regions with known anatomical connections suggested that cerebellar, substantia nigra, and basal ganglia efferents may be abnormal. These studies complement existing biochemical and neuropharmacological data which show abnormalities in the cerebellum of the dt rat. Additionally, the function of brain stem and even basal ganglia nuclei is affected in this mutant, perhaps as a consequence of abnormal cerebellar activity. The partial effects in the littermates suggest that abnormalities in only a few regions are not sufficient to produce the movement disorder, and a gene dose effect may exist.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Correlation Analysesmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Regional cerebral glucose utilization reveals widespread abnormalities in the motor system of the rat mutant dystonic

Brown

Lorden

1989

J. Neurosci.

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Transneuronal pathways to the vestibulocerebellum

et al. 1996

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The alpha-herpes virus (pseudorabies, PRV) was used to observe central nervous system (CNS) pathways associated with the vestibulocerebellar system. Retrograde transneuronal migration of alpha-herpes virions from specific lobules of the gerbil and rat vestibulo-cerebellar cortex was detected immunohistochemically. Using a time series analysis, progression of infection along polyneuronal cerebellar afferent pathways was examined. Pressure injections of > 20 nanoliters of a 10(8) plaque forming units (pfu) per ml solution of virus were sufficient to initiate an infectious locus which resulted in labeled neurons in the inferior olivary subnuclei, vestibular nuclei, and their afferent cell groups in a progressive temporal fashion and in growing complexity with increasing incubation time. We show that climbing fibers and some other cerebellar afferent fibers transported the virus retrogradely from the cerebellum within 24 hours. One to three days after cerebellar infection discrete cell groups were labeled and appropriate laterality within crossed projections was preserved. Subsequent nuclei labeled with PRV after infection of the flocculus/paraflocculus, or nodulus/uvula, included the following: vestibular (e.g., z) and inferior olivary nuclei (e.g., dorsal cap), accessory oculomotor (e.g., Darkschewitsch n.) and accessory optic related nuclei, (e.g., the nucleus of the optic tract, and the medial terminal nucleus); noradrenergic, raphe, and reticular cell groups (e.g., locus coeruleus, dorsal raphe, raphe pontis, and the lateral reticular tract); other vestibulocerebellum sites, the periaqueductal gray, substantia nigra, hippocampus, thalamus and hypothalamus, amygdala, septal nuclei, and the frontal, cingulate, entorhinal, perirhinal, and insular cortices. However, there were differences in the resulting labeling between infection in either region. Double-labeling experiments revealed that vestibular efferent neurons are located adjacent to, but are not included among, flocculus-projecting supragenual neurons. PRV transport from the vestibular labyrinth and cervical muscles also resulted in CNS infections. Virus propagation in situ provides specific connectivity information based on the functional transport across synapses. The findings support and extend anatomical data regarding vestibulo-olivo-cerebellar pathways.

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Regional changes in brain 5-HT1A serotonin receptors in the rat model of persistent spasmodic dyskinesias induced by iminodipropionitrile

et al. 1989

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Involvement of nigrotecto-reticulospinal pathways in the iminodipropionitrile (IDPN) model of spasmodic dyskinesias: a 2-deoxy-d-[1-14C]glucose study in the rat

Cited by 11 publications

References 48 publications

Regional cerebral glucose utilization reveals widespread abnormalities in the motor system of the rat mutant dystonic

Regional cerebral glucose utilization reveals widespread abnormalities in the motor system of the rat mutant dystonic

Transneuronal pathways to the vestibulocerebellum

Regional changes in brain 5-HT1A serotonin receptors in the rat model of persistent spasmodic dyskinesias induced by iminodipropionitrile

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