Involvement of monoaminergic system in the antidepressant-like effect of the hydroalcoholic extract of Siphocampylus verticillatus

Rodrigues, Ana Lúcia S.; Silva, Gisele L. da; Mateussi, Andreza S.; Fernandes, Elizabeth S.; Miguel, Obdúlio Gomes; Yunes, Rosendo A.; Calixto, João B.; Santos, Adair R.S.

doi:10.1016/s0024-3205(01)01498-9

Cited by 180 publications

(97 citation statements)

References 29 publications

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“…2 extracellular 5-HT (Pozzi et al, 1999). Although 5-HT depletion prevented the anti-immobility effect of fluoxetine in the FST in rats and mice (Page et al, 1999;Rodrigues et al, 2002;Gavioli et al, 2004), it had much less effect (like that of paroxetine and sertraline) in dopamine ␤-hydroxylase (Dbh) knock-out mice (Cryan et al, 2004), whereas the anti-immobility effect of sertraline in rats was not affected by 5-HT depletion . Unfortunately, Lucki et al (2001) did not assess whether the anti-immobility effect of fluoxetine in DBA/2J mice depends on endogenous 5-HT.…”

Section: Discussionmentioning

confidence: 99%

Genotype-Dependent Activity of Tryptophan Hydroxylase-2 Determines the Response to Citalopram in a Mouse Model of Depression

Cervo¹,

Canetta²,

Calcagno³

et al. 2005

J. Neurosci.

129

132

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Section: Discussionmentioning

confidence: 99%

Genotype-Dependent Activity of Tryptophan Hydroxylase-2 Determines the Response to Citalopram in a Mouse Model of Depression

Cervo¹,

Canetta²,

Calcagno³

et al. 2005

J. Neurosci.

129

132

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“…The initial dynamic (vigorous) behavior followed by progressive periods of immobility was observed which was aimed at rescuing themselves from the unpleasant situation termed helplessness. The duration of immobility was documented for 6 min, excluding the initial 2 min of struggling (Dhingra and Chhillar 2012;Rodrigues et al 2002;Steru et al 1985).…”

Section: Tail Suspension Test (Tst)mentioning

confidence: 99%

Antidepressant and anxiolytic effects of Garcinia indica fruit rind via monoaminergic pathway

2017

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Depression and anxiety are the most crippling neuropsychiatric disorders of this modern era. These mostly occur as anxiety followed by depression or in mixed state. Therefore, there is an urgent need of a safe and effective treatment, which proves its worth in this ailment. What else than a conventional food would be a better choice for a convenient therapy. Therefore, Garcinia indica, commonly known as Kokam, fruit rind has been used in the present study to investigate its antidepressant and anti-anxiety potential using forced swim test, tail suspension test, and reserpine-induced hypothermia; and elevated plus maze, hole-board test, and light dark model, respectively. Garcinia indica fruit rind given to mice with food for consecutive 14 days at 0.5, 1, and 2% w/w significantly (p \ 0.05) reduced despair behavior in forced swim test, immobility duration in tail suspension test, and also switched the hypothermia (reserpine induced) to normal temperature significantly (p \ 0.05). Garcinia indica significantly (p \ 0.05) raised the time elapsed and count of entries in open arms of elevated plus maze, enhanced incidence of head dipping in holes of hole board along with duration of expending time in lit compartment of light dark model, exhibiting its anti-anxiety effect. Garcinia indica significantly reduced monoamine oxidase and malondialdehyde levels providing support to neuroprotective potential of fruit rind. The mechanistic study showed the participation of G. indica at a 1 -adrenoceptor and D 2 -dopamine receptor, by attenuating prazosin and sulpirideinduced increase in immobility duration. Garcinia indica fruit rind showed a significant antidepressant and anxiolytic effect while no effect on locomotor activity, i.e., no psycho-stimulation.

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“…Forced swimming test and tail suspension test were utilized for assessment of antidepressantlike activity. These models are broadly utilized in rodents to anticipate antidepressant-like potential by evaluating the reduction in immobility time (Rodrigues et al, 2002;Suzuki et al, 2001). The behavioral parameter measured in both tests is called immobility, resembling a behavioral condition of hopelessness, as evidenced in human depression (Steru et al, 1985).…”

Section: Discussionmentioning

confidence: 99%

Vitis vinifera juice ameliorates depression-like behavior in mice by modulating biogenic amine neurotransmitters

Aslam

Sultana

2015

Bangladesh J Pharmacol

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The advantageous effects of Vitis vinifera juice on depressive model mice were examined utilizing a blend of behavioral evaluations and biogenic amine neurotransmitter estimations. During the behavioral evaluations, immobility time on the forced swimming test and tail suspension test were measured in unstressed and immobilization-induced stressed mice. V. vinifera juice (4 mL/kg and 8 mL/kg) and fluoxetine (20 mg/kg) produced a significant decrease in immobility time of both unstressed and stressed mice when compared with their respective saline-treated control groups in both paradigms. Neurotransmitters were measured using high-performance liquid chromatography with electrochemical detector. V. vinifera juice raised the levels of both serotonin (p<0.001) and noradrenalin (p<0.001) in brain tissue. These outcomes give significant mechanistic insights into the protective effect of V. vinifera juice against depressive disorders. Our results showed that V. vinifera juice could relieve depressive manifestations in the rodent model of depression.

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Involvement of monoaminergic system in the antidepressant-like effect of the hydroalcoholic extract of Siphocampylus verticillatus

Cited by 180 publications

References 29 publications

Genotype-Dependent Activity of Tryptophan Hydroxylase-2 Determines the Response to Citalopram in a Mouse Model of Depression

Genotype-Dependent Activity of Tryptophan Hydroxylase-2 Determines the Response to Citalopram in a Mouse Model of Depression

Antidepressant and anxiolytic effects of Garcinia indica fruit rind via monoaminergic pathway

<i>Vitis vinifera</i> juice ameliorates depression-like behavior in mice by modulating biogenic amine neurotransmitters

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