Involvement of Meteorological Factors and Sex in the Occurrence of Subarachnoid Hemorrhage in Japan

Umemura, Kimiko; Hirashima, Yutaka; Kurimoto, Masanori; Kuwayama, Naoya; Kubo, Michiya; Origasa, Hideki; Doshi, Masaru; Endo, Shunro

doi:10.2176/nmc.48.101

Cited by 26 publications

(18 citation statements)

References 32 publications

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“…Aneurysmal rupture can also occur during stressful or strenuous activities such as sexual intercourse, labor, defecation, physical exertion, or sports [55]. However, these external factors may in fact conceal the climate impact, as numerous studies indicate a higher incidence of aneurysm rupture during the winter season, as well as during daytime [56][57][58][59]. Our experience of operated aneurysms also supports this statement, as illustrated in Figure 1.…”

Section: Natural History Of Unruptured Aneurysmssupporting

confidence: 72%

Preventing Rupture: Clipping of Unruptured Intracranial Aneurysms

Florian¹,

Aldea²,

Florian³

2020

New Insight Into Cerebrovascular Diseases - An Updated Comprehensive Review

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Unruptured intracranial aneurysms (UIAs) represent a major public health issue due to their unpredictable natural history. Whether to actively treat them or to maintain them under observation remains a hotly disputed topic. In this chapter, we present a review of the literature regarding the history of clipping and its use in UIAs, as well as the experience of our senior author in this field. We performed an extensive Medline and Google Academic search of the relevant literature. We have also made a retrospective analysis on patients harboring UIAs and multiple intracranial aneurysms (MIAs) clipped by the senior author between 1997 and 2017. About 89 patients had solitary UIAs, alongside 101 with MIAs possessing 257 individual aneurysms in total. All UIA patients were discharged with a favorable neurological outcome and no mortality. Concerning MIAs, the majority of cases had 2 aneurysms, the highest number being 6. And, 61 patients from this group had a favorable outcome. In the hands of experienced vascular neurosurgeons, clipping remains a safe option for both UIAs and MIAs. This procedure offers a long-lasting protection from aneurysmal rupture. In the future, new clip technologies and intraprocedural methods of verifying vessel patency and aneurysmal occlusion may further enhance postoperative results.

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Section: Natural History Of Unruptured Aneurysmssupporting

confidence: 72%

Preventing Rupture: Clipping of Unruptured Intracranial Aneurysms

Florian¹,

Aldea²,

Florian³

2020

New Insight Into Cerebrovascular Diseases - An Updated Comprehensive Review

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“…Differences in peak onset of aneurysmal SAH between males and females have been reported by some [3,4,5,6], but other studies have indicated no differences in seasonal variation between males and females. A Danish study [12] on differences in seasonal variation between males and females concluded that there was ‘little difference by sex', with a peak onset in females in October and in males in November.…”

Section: Discussionmentioning

confidence: 85%

“…To date, intraday variations [1], intraweek variations [2], and intrayear variations in the incidence of aneurysmal SAH have been reported. Although seasonal variations have been observed by some authors [1,3,4,5,6], other studies have indicated no seasonal variations [7]. However, in most of these studies, methodological limitations have been identified [7].…”

Section: Introductionmentioning

confidence: 99%

Seasonal Variation in the Incidence of Aneurysmal Subarachnoid Hemorrhage Associated with Age and Gender: 20-Year Results from the Yamaguchi Cerebral Aneurysm Registry

Ishihara

Kunitsugu²,

Nomura³

et al. 2013

Neuroepidemiology

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Background: This study was a cerebral aneurysm registry study conducted in a region with few climatic differences. Based on data collected for over 20 years, seasonal variations and characteristics of subarachnoid hemorrhage (SAH) due to ruptured aneurysms were analyzed. Methods: This study included 5,007 patients in the Yamaguchi Prefecture with aneurysmal SAH between 1986 and 2005. Incidence rates by month, sex, age, severity, and aneurysm site were analyzed. Results: In women, seasonal variation was observed, in particular among those aged ≥50 years. Among those aged 50-69 years, the highest incidence was in October, and the nadir was in June (peak-to-trough ratio = 1.72). At age ≥70 years, this was slightly different, with the highest incidence in December and the nadir in July (peak-to-trough ratio = 1.48). However, there was no seasonal variation in men overall; it was limited to elderly men at age ≥70 years, with the highest incidence in January and the nadir in July (peak-to-trough ratio = 2.9). Aneurysm site and severity showed no relationship with seasonal variation. Conclusion: The present study shows seasonal variations in the onset of SAH. Seasonal variations in SAH differed depending on age and sex.

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“…Unlike most other types of cerebrovascular disease, SAH occurs more frequently in women than in men. Mortality rates of female SAH patients have been reported to be higher than those for men 2,3,8,9,15,16,19,23,25,32,33) . Despite the catastrophic consequence of aneurysmal SAH, very little is understood regarding their pathogenesis, and there are no reliable predictive markers for identifying risk aneurysm rupture.…”

Section: Introductionmentioning

confidence: 99%

“…The cerebral aneurysm is a prevalent acquired cerebrovascular disease that can cause a catastrophic subarachnoid hemorrhage (SAH). Mortality rates for aneurysmal SAH continue to average near 50%, with 10% of patients dying before ever reaching the hospital and approximately 20% sustaining severe disability 1,6,7,18,29,32) . Unlike most other types of cerebrovascular disease, SAH occurs more frequently in women than in men.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Estrogen Hormone and Rupture of Cerebral Aneurysm in Premenopausal Women

Koo

Hwang

2019

Nerve

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The incidence of subarachnoid hemorrhage (SAH) in women increase after menopause. Estrogen hormone had been implicated in cerebral aneurysm formation, growth and rupture. The aim of this study was to examine the association between estrogen hormone and presence of aneurysmal SAH in premenopausal women. Methods: Between February 2015 and December 2016, 40 patients at consecutive premenopausal women (mean age, 41 years) with aneurysms SAH, were treated in our hospital. The data of patients with clinical and gynecological history were analyzed and compared with control group with age matched, case-control study. Results: Single and multivariate analysis showed that estrogen hormone (estradiol) had a lower trend towards at premenopause age comparing with control group, statistically was significant (p<0.001). No significant association of SAH was found with gynecological and clinical factors (p>0.05). Conclusion: In our study, there is a trend showing that an earlier age at menopause relating to estrogen hormone deficiency is associated with the aneurysmal SAH. These data may help to identify a risk factor for pathogenesis of cerebral aneurysm and also a potential target for future therapies.

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Involvement of Meteorological Factors and Sex in the Occurrence of Subarachnoid Hemorrhage in Japan

Cited by 26 publications

References 32 publications

Preventing Rupture: Clipping of Unruptured Intracranial Aneurysms

Preventing Rupture: Clipping of Unruptured Intracranial Aneurysms

Seasonal Variation in the Incidence of Aneurysmal Subarachnoid Hemorrhage Associated with Age and Gender: 20-Year Results from the Yamaguchi Cerebral Aneurysm Registry

Relationship between Estrogen Hormone and Rupture of Cerebral Aneurysm in Premenopausal Women

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