Involvement of macrophage colony-stimulating factor (M-CSF) in the function of follicular granulosa cells

Zhang, Zhifen; Qin, Fang; Wang, Jianmin

doi:10.1016/j.fertnstert.2007.06.098

Cited by 15 publications

(14 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to acting as chemokines, GM-CSF and IL-8, acting as cytokines, also regulate the ovarian cell functions. During follicular growth, GM-CSF increases preantral follicle progression and decreases granulosa cell proliferation and synthesis of 17β-estradiol (E2) and progesterone (P4) (Gilchrist et al 2000, Wang et al 2005, Zhang et al 2008. Interleukin-8 stimulates follicular progression from preantral to pre-ovulatory stage (Goto et al 1997).…”

Section: Physiological Cytokine and Chemokine Signaling In The Ovarymentioning

confidence: 99%

Obesity induces ovarian inflammation and reduces oocyte quality

2019

View full text Add to dashboard Cite

In the United States, 36.5% of women between the ages of 20 and 39 years are obese. This obesity results in not only metabolic disorders including type II diabetes and cardiovascular disease, but also impaired female fertility. Systemic and tissue-specific chronic inflammation and oxidative stress are common characteristics of obesity. This is also true in the ovary. Several studies have demonstrated that pro-inflammatory cytokines and reactive oxygen species alter estrous cyclicity, steroidogenesis and ovulation. Inflammation and oxidative stress also impair meiotic and cytoplasmic maturation of the oocyte which reduces its developmental competence for fertilization and pre-implantation embryo development. Interestingly, there is recent evidence that obesity-and/or polycystic ovary syndrome (PCOS)-dependent changes to the gut microbiome contributes to ovarian inflammation, steroidogenesis and the expression of mRNAs in the oocyte. However, several gaps remain necessitating future studies to identify inflammation, oxidative stress and gut microbiome mechanisms that reduce ovarian function and oocyte quality.Reproduction (2019) 158 R79-R90

show abstract

Section: Physiological Cytokine and Chemokine Signaling In The Ovarymentioning

confidence: 99%

Obesity induces ovarian inflammation and reduces oocyte quality

2019

View full text Add to dashboard Cite

show abstract

“…Macrophages. Macrophages are the most abundant immune cells within the adipose tissue and ovary, both in animals and humans [18,19], particularly in the thecal, luteal, and atretic follicles, where they participate in multiple processes in the ovary, such as folliculogenesis and ovulation [19,20]. Macrophages are also crucial for maintaining a balance between protective and destructive cell-mediated immunity in the healing phase of inflammation [21].…”

Section: Innate Immune Cells and Pcosmentioning

confidence: 99%

Immunophenotypic Profiles in Polycystic Ovary Syndrome

Pang

et al. 2020

Mediators of Inflammation

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS) a long-known endocrinopathy and one of the most common endocrine-reproductivemetabolic disorders in women, which can lead to infertility. Although the precise etiology remains unclear, PCOS is considered as a complex genetic trait, with a high degree of heterogeneity. Besides, hormones and immune cells, including both innate and adaptive immune cells, are reportedly a cross talk in PCOS. Chronic low-grade inflammation increases autoimmune disease risk. This proinflammatory condition may, in turn, affect vital physiological processes that ultimately cause infertility, such as ovulation failure and embryo implantation. Here, we review the accumulating evidence linking PCOS with inflammatory status providing an overview of the underlying hormone-mediated dysregulation of immune cells. We mainly focus on the correlational evidence of associations between immune status in women and the increased prevalence of PCOS, along with the specific changes in immune responses. Further recognition and exploration of these interactions may help elucidate PCOS pathophysiology and highlight targets for its treatment and prevention.

show abstract

“…Because of the ready availability of granulosal cells and follicular fluid from follicles of women undergoing IVF procedures, the presence of immune cells and cytokines in follicles can be measured and correlated with pregnancy outcome in humans. Macrophage colony‐stimulating factor (CSF1) and its receptor are expressed in, and increase steroidogenesis by, human granulosal cells 18,19 . Granulosal cells also produce the chemokine CXCL12 and express its receptor, CXCR4 20 .…”

Section: Leukocytes In Follicular Development Ovulation and Luteinizmentioning

confidence: 99%

The Interface of the Immune and Reproductive Systems in the Ovary: Lessons Learned from the Corpus Luteum of Domestic Animal Models

Pate

Toyokawa

Walusimbi

et al. 2010

American J Rep Immunol

View full text Add to dashboard Cite

Citation Pate JL, Toyokawa K, Walusimbi S, Brzezicka E. The interface of the immune and reproductive systems in the ovary: lessons learned from the corpus luteum of domestic animal models. Am J Reprod Immunol 2010 The dynamic changes that characterize the female reproductive system are regulated by hormones. However, local cell‐to‐cell interactions may mediate responsiveness of tissues to hormonal signals. The corpus luteum (CL) is an excellent model for understanding how immune cells are recruited into tissues and the role played by those cells in regulating tissue homeostasis or demise. Leukocytes are recruited into the CL throughout its lifespan, and leukocyte‐derived cytokines have been found in corpora lutea of all species examined. The proinflammatory cytokines inhibit gonadotropin‐stimulated steroidogenesis, profoundly stimulate prostaglandin synthesis by luteal cells, and promote apoptosis. However, there is mounting evidence that leukocytes and luteal cells communicate in different ways to maintain homeostasis within the functional CL. Domestic animals have provided important information regarding the presence and role of immune cells in the CL.

show abstract

Involvement of macrophage colony-stimulating factor (M-CSF) in the function of follicular granulosa cells

Cited by 15 publications

References 24 publications

Obesity induces ovarian inflammation and reduces oocyte quality

Obesity induces ovarian inflammation and reduces oocyte quality

Immunophenotypic Profiles in Polycystic Ovary Syndrome

The Interface of the Immune and Reproductive Systems in the Ovary: Lessons Learned from the Corpus Luteum of Domestic Animal Models

Contact Info

Product

Resources

About