Involvement of Locus Coeruleus Noradrenergic Neurons in Supraspinal Antinociception by α,β-Methylene-ATP in Rats

Fukui, Masato; Takishita, Azusa; Zhang, Nannan; Nakagawa, Takayuki; Minami, Masabumi; Satoh, Masamichi

doi:10.1254/jphs.94.153

Cited by 19 publications

(10 citation statements)

References 41 publications

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“…Antinociceptive effects in peripheral tissues were registered after bilateral microinjecton of α,β-meATP into the nucleus locus coeruleus [138] and intracerebroventricular instillation of α,β-meATP [139]. Furthermore, intracerebroventricular administration of the selective P2X 3 receptor antagonist A-317491 or pretreatment with antisense oligonucleotides for the P2X 3 gene decreased inflammatory nociceptive behaviors induced by intraplantar injection of formalin and intraperitoneal injection of acetic acid [139].…”

Section: P2x 3 Receptors In Inflammatory Painmentioning

confidence: 99%

P2X3 Receptor Involvement in Pain States

2007

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The understanding of how pain is processed at each stage in the peripheral and central nervous system is the precondition to develop new therapies for the selective treatment of pain. In the periphery, ATP can be released from various cells as a consequence of tissue injury or visceral distension and may stimulate the local nociceptors. The highly selective distribution of P2X(3) and P2X(2/3) receptors within the nociceptive system has inspired a variety of approaches to elucidate the potential role of ATP as a pain mediator. Depolarization by ATP of neurons in pain-relevant neuronal structures such as trigeminal ganglion, dorsal root ganglion, and spinal cord dorsal horn neurons are well investigated. P2X receptor-mediated afferent activation appears to have been implicated in visceral and neuropathic pain and even in migraine and cancer pain. This article reviews recently published research describing the role that ATP and P2X receptors may play in pain perception, highlighting the importance of the P2X(3) receptor in different states of pain.

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Section: P2x 3 Receptors In Inflammatory Painmentioning

confidence: 99%

P2X3 Receptor Involvement in Pain States

2007

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“…In addition, high levels of 26RFa receptors have also been observed in various brain nuclei involved in the processing of pain such as the parafascicular thalamic nucleus (Weigel and Krauss, 2004), the locus coeruleus (Fukui et al, 2004;Imbe et al, 2004), the dorsal raphe nucleus (Foo and Mason, 2003;Cucchiaro et al, 2005), and the parabrachial nucleus (Cortelli and Pierangeli, 2003;Richard et al, 2005). The NPFF2 receptor has been previously reported also to be present in these nuclei (Elshourbagy et al, 2000;Zeng et al, 2003;Gouarderes et al, 2004), and the role of NPFF, one of the endogenous ligand of NPFF2 (Engström et al, 2003), in the modulation of pain transmission is now widely accepted (for review see Mollereau et al, 2005).…”

Section: Functional Considerationsmentioning

confidence: 99%

Distribution of 26RFa binding sites and GPR103 mRNA in the central nervous system of the rat

Bruzzone

Lectez

Dionne‐Laporte

et al. 2007

J of Comparative Neurology

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The novel RFamide peptide 26RFa, the endogenous ligand of the orphan receptor GPR103, affects food intake, locomotion, and activity of the gonadotropic axis. However, little is known regarding the localization of 26RFa receptors. The present report provides the first detailed mapping of 26RFa binding sites and GPR103 mRNA in the rat central nervous system (CNS). 26RFa binding sites were widely distributed in the brain and spinal cord, whereas the expression of GPR103 mRNA was more discrete, notably in the midbrain, the pons, and the medulla oblongata, suggesting that 26RFa can bind to a receptor(s) other than GPR103. Competition experiments confirmed that 26RFa interacts with an RFamide peptide receptor distinct from GPR103 that may be NPFF2. High densities of 26RFa binding sites were observed in olfactory, hypothalamic, and brainstem nuclei involved in the control of feeding behavior, including the piriform cortex, the ventromedial and dorsomedial hypothalamic nuclei, the paraventricular nucleus, the arcuate nucleus, the lateral hypothalamic area, and the nucleus of the solitary tract. The preoptic and anterior hypothalamic areas were also enriched with 26RFa recognition sites, supporting a physiological role of the neuropeptide in the regulation of the gonadotropic axis. A high density of 26RFa binding sites was detected in regions of the CNS involved in the processing of pain, such as the dorsal horn of the spinal cord and the parafascicular thalamic nucleus. The wide distribution of 26RFa binding sites suggests that 26RFa has multiple functions in the CNS that are mediated by at least two distinct receptors.

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“…A recent study determined P2X 1 , P2X 3 , and P2X 2/3 receptors involvement in carrageenan-induced TMJ inflammatory hyperalgesia (18). Conversely, there are data suggesting that P2X purinoceptors, especially P2X 3 and P2X 2/3 , could be involved in antinociception (19,20). …”

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confidence: 99%

The role of P2X3 receptors in bilateral masseter muscle allodynia in rats

Knežević

Vukman²,

Robert³

et al. 2016

Croat Med J

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AimTo determine the relationship between bilateral allodynia induced by masseter muscle inflammation and P2X3 receptor expression changes in trigeminal ganglia (TRG) and the influence of intramasseteric P2X3 antagonist administration on bilateral masseter allodynia.MethodsTo induce bilateral allodynia, rats received a unilateral injection of complete Freund’s adjuvant (CFA) into the masseter muscle. Bilateral head withdrawal threshold (HWT) was measured 4 days later. Behavioral measurements were followed by bilateral masseter muscle and TRG dissection. Masseter tissue was evaluated histopathologically and TRG tissue was analyzed for P2X3 receptor mRNA expression by using quantitative real-time polymerase chain reaction (PCR) analysis. To assess the P2X3 receptor involvement in nocifensive behavior, two doses (6 and 60 μg/50 μL) of selective P2X3 antagonist A-317491 were administrated into the inflamed masseter muscle 4 days after the CFA injection. Bilateral HWT was measured at 15-, 30-, 60-, and 120-minute time points after A-317491 administration.ResultsHWT was bilaterally reduced after the CFA injection (P < 0.001). Intramasseteric inflammation was confirmed ipsilaterally to the CFA injection. Quantitative real-time PCR analysis demonstrated enhanced P2X3 expression in TRG ipsilaterally to CFA administration (P < 0.01). In comparison with controls, the dose of 6 μg of A-317491 significantly increased bilateral HWT at 15-, 30-, and 60-minute time points after the A-317491 administration (P < 0.001), whereas the dose of 60 μg of A-317491 was efficient at all time points ipsilaterally (P = 0.004) and at 15-, 30-, and 60-minute time points contralaterally (P < 0.001).ConclusionUnilateral masseter inflammation can induce bilateral allodynia in rats. The study provided evidence that P2X3 receptors can functionally influence masseter muscle allodynia and suggested that P2X3 receptors expressed in TRG neurons are involved in masseter inflammatory pain conditions.

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Involvement of Locus Coeruleus Noradrenergic Neurons in Supraspinal Antinociception by α,β-Methylene-ATP in Rats

Cited by 19 publications

References 41 publications

P2X3 Receptor Involvement in Pain States

P2X3 Receptor Involvement in Pain States

Distribution of 26RFa binding sites and GPR103 mRNA in the central nervous system of the rat

The role of P2X3 receptors in bilateral masseter muscle allodynia in rats

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