Involvement of JAK/STAT signaling in the effect of cornel iridoid glycoside on experimental autoimmune encephalomyelitis amelioration in rats

Yin, Linlin; Chen, Yongyan; Zhao, Qian; Zhang, Li; Wang, Qi; Zhang, Qi; Li, Lin

doi:10.1016/j.jneuroim.2014.06.022

Cited by 26 publications

(14 citation statements)

References 53 publications

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“…Within the 10 herbs to formulate YGPs, five of which, include rehmannia glutinosa, fructus lycii, cuscutae semen, cinnamomi cortex and corni fructus, were reported to have immunomodulatory (Han et al, 2012;Yin et al, 2014), antioxidant (Chung et al, 2011;Zhang et al, 2009), anti-amnesic (Kwon et al, 2009), anti-aging (Rattanajarasroj and Unchern, 2010Yu et al, 2007) and neurotrophic activities (Kim et al, 2015;Yu et al, 2006;Zhao et al, 2010). The chemical ingredients of principle pharmacological functions identified are mainly classified into iridoid glycosides (sweroside and loganin), alkaloids (betaine, songorine, fuziline and neoline), flavonoids (hyperin and quercitrin) and organic acids (chlorogenic acid).…”

Section: Discussionmentioning

confidence: 99%

“…The chemical ingredients of principle pharmacological functions identified are mainly classified into iridoid glycosides (sweroside and loganin), alkaloids (betaine, songorine, fuziline and neoline), flavonoids (hyperin and quercitrin) and organic acids (chlorogenic acid). Most of these compounds were known with neuroprotective effects by regulating nerve growth factor (NGF) , BDNF (Yin et al, 2014), glial cell line-derived neurotrophic factor (GDNF) (Yu et al, 2006), NF-kappaB (Han et al, 2012;Kim et al, 2015) in YGPs.…”

Section: Discussionmentioning

confidence: 99%

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You-Gui pills promote nerve regeneration by regulating netrin1, DCC and Rho family GTPases RhoA, Racl, Cdc42 in C57BL/6 mice with experimental autoimmune encephalomyelitis

Liu

Chen

et al. 2016

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

You-Gui pills promote nerve regeneration by regulating netrin1, DCC and Rho family GTPases RhoA, Racl, Cdc42 in C57BL/6 mice with experimental autoimmune encephalomyelitis

Liu

Chen

et al. 2016

Journal of Ethnopharmacology

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“…Some special reports indicate the improvement of neurological functions in rats after feeding with iridoid glycosides from C. officinalis (Yao et al, 2009). Additionally, in the experimental autoimmune encephalomyelitis in animal models the administration of cornel iridoid glycoside significantly attenuated the symptoms of multiple sclerosis via an increased expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) as well as inhibition of JAK/STAT1 and JAK/STAT3 phosphorylation and reduction of proinflammatory mediators, such as TNF-α, IL-1β, IFN-γ, IL-17 (Yin et al, 2014; Qu et al, 2016). Iridoids of C. officinalis also protect glutamate-injured hippocampal cells (Jeong et al, 2012).…”

Section: Similarities and Differences Of Pharmacological Effects Or Bmentioning

confidence: 99%

Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used

Czerwińska

Melzig

2018

Front. Pharmacol.

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Among 65 species belonging to the genus Cornus only two, Cornus mas L. and Cornus officinalis Sieb. et Zucc. (Cornaceae), have been traditionally used since ancient times. Cornus mas (cornelian cherry) is native to southern Europe and southwest Asia, whereas C. officinalis (Asiatic dogwood, cornel dogwood) is a deciduous tree distributed in eastern Asia, mainly in China, as well as Korea and Japan. Based on the different geographic distribution of the closely related species but clearly distinct taxa, the ethnopharmacological use of C. mas and C. officinalis seems to be independently originated. Many reports on the quality of C. mas fruits were performed due to their value as edible fruits, and few reports compared their physicochemical properties with other edible fruits. However, the detailed phytochemical profiles of C. mas and C. officinalis, in particular fruits, have never been compared. The aim of this review was highlighting the similarities and differences of phytochemicals found in fruits of C. mas and C. officinalis in relation to their biological effects as well as compare the therapeutic use of fruits from both traditional species. The fruits of C. mas and C. officinalis are characterized by the presence of secondary metabolites, in particular iridoids, anthocyanins, phenolic acids and flavonoids. However, much more not widely known iridoids, such as morroniside, as well as tannins were detected particularly in fruits of C. officinalis. The referred studies of biological activity of both species indicate their antidiabetic and hepatoprotective properties. Based on the available reports antihyperlipidemic and anticoagulant activity seems to be unique for extracts of C. mas fruits, whereas antiosteoporotic and immunomodulatory activities were assigned to preparations of C. officinalis fruits. In conclusion, the comparison of phytochemical composition of fruits from both species revealed a wide range of similarities as well as some constituents unique for cornelian cherry or Asiatic dogwood. Thus, these phytochemicals are considered the important factor determining the biological activity and justifying the use of C. mas and C. officinalis in the traditional European and Asiatic medicine.

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“…Inhibit the process of T cell entry to the central nervous system and attenuate microglia activation. Increase BDNF expression and decrease phosphorylation of JAK/STAT1/3 and inflammatory cytokines production, e.g., IL-1β, IFN-γ, TNF-α [ 48 ] Iridoid glycosides Mycobacterium tuberculosis and myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis mouse as multiple sclerosis model Decrease BDNF and NGF loss in the spinal cord [ 50 ] Aqueous extract PC 12 cell lines Increase cell neurite outgrowth. Inhibit extracellular Ca 2+ influx, and protein and mRNA levels of STIM1 [ 44 ] Hepatoprotective activity 5-Hydroxymethylfurfural Hydrogen peroxide-induced L02 cell lines as in vitro hepatitis model Promote S phase into G2/M phase and recover cell cycle to normal.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Corni Fructus: a review of chemical constituents and pharmacological activities

et al. 2018

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Cornus officinalis Sieb. et Zucc. is part of the genus Cornus of the family Cornaceae. Ripening and dry fruits (Corni Fructus) are recognized as an essential herb medicine in the traditional Chinese medicine (TCM) and have been widely used for over 2000 years. This review provides a comprehensive summary of Corni Fructus (CF), including the botany, phytochemistry, traditional use, and current pharmacological activities. According to the basic theory of TCM, CF usually participates in various Chinese medicinal formulae to exert the essential roles in replenishing liver and kidney, arresting seminal emission and sweat. Based on modern pharmacological studies, about 90 compounds have been isolated and identified from CF. In vivo and in vitro experimental studies indicate that CF exhibits extensive pharmacological activities including hypoglycemic, antioxidant, anti-inflammatory, anticancer, neuroprotective, hepatoprotective, and nephroprotective activities. However, only about 18% of chemical constituents in CF were tested. It means the potential pharmacological activities and clinical values of CF need to be further investigated.

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Involvement of JAK/STAT signaling in the effect of cornel iridoid glycoside on experimental autoimmune encephalomyelitis amelioration in rats

Cited by 26 publications

References 53 publications

You-Gui pills promote nerve regeneration by regulating netrin1, DCC and Rho family GTPases RhoA, Racl, Cdc42 in C57BL/6 mice with experimental autoimmune encephalomyelitis

You-Gui pills promote nerve regeneration by regulating netrin1, DCC and Rho family GTPases RhoA, Racl, Cdc42 in C57BL/6 mice with experimental autoimmune encephalomyelitis

Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used

Corni Fructus: a review of chemical constituents and pharmacological activities

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