Corni Fructus: a review of chemical constituents and pharmacological activities

Dong, Yu; Feng, Zhe; Chen, Hubiao; Wang, Fu Sheng; Lu, Jiahong

doi:10.1186/s13020-018-0191-z

Cited by 94 publications

(57 citation statements)

References 67 publications

(94 reference statements)

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“…According to Dong et al [ 42 ], thirty tannins have been identified in the fruit of C. officinalis , which is considered to be a rich source of gallotannins and ellagitannins. The groups of Hatano and Okuda have broadly investigated the hydrolyzable tannins as follows: their isolation, identification of their structures, and occurrence of several isomers as a result of anomerization at the glucose cores of tannins in C. officinalis [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 43 ].…”

Section: Resultsmentioning

confidence: 99%

Cornus mas L. Stones: A Valuable by-Product as an Ellagitannin Source with High Antioxidant Potential

et al. 2020

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The stone of Cornus mas L. remains the least known morphological part of this plant, whereas the fruit is appreciated for both consumption purposes and biological activity. The stone is considered to be a byproduct of fruit processing and very little is known about its phytochemical composition and biological properties. In this study, the complete qualitative determination of hydrolyzable tannins, their quantitative analysis, total polyphenolic content, and antioxidant properties of the stone of C. mas are presented for the first time. The 37 identified compounds included the following: various gallotannins (11), monomeric ellagitannins (7), dimeric ellagitannins (10), and trimeric ellagitannins (7). The presence of free gallic acid and ellagic acid was also reported. Our results demonstrate that C. mas stone is a source of various bioactive hydrolyzable tannins and shows high antioxidant activity which could allow potential utilization of this raw material for recovery of valuable pharmaceutical or nutraceutical substances. The principal novelty of our findings is that hydrolyzable tannins, unlike other polyphenols, have been earlier omitted in the evaluation of the biological activities of C. mas. Additionally, the potential recovery of these bioactive chemicals from the byproduct is in line with the ideas of green chemistry and sustainable production.

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Section: Resultsmentioning

confidence: 99%

Cornus mas L. Stones: A Valuable by-Product as an Ellagitannin Source with High Antioxidant Potential

et al. 2020

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“…NF-κB-induced cytokines further stimulate, activate and differentiate lamina propria immune cells, which aggravates the perpetuation of mucosal inflammation. In this review, we find that 55% of Chinese medicines having the abilities of regulating NF-κB expression in macrophages (e.g., SM934, artesunate, aesculin, gallic acid and epicatechin) repress the nucleus translocation and phosphorylation of NF-κBp65, inhibit the protein expressions and phosphorylation of NF-κB, whereas 45% (e.g., berberine, [162][163][164].…”

Section: Dss-induced Colon Tissuementioning

confidence: 99%

Targeting NF-κB pathway for treating ulcerative colitis: comprehensive regulatory characteristics of Chinese medicines

Zhao

2020

Chin Med

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Nuclear factor-kappa B (NF-κB) is a kind of multi-functional nuclear transcription factor involved in regulating gene transcription to influence pathological evolution of inflammatory and immune diseases. Numerous literature evidence that NF-κB pathway plays an essential role in pathogenic development of ulcerative colitis (UC). UC is a chronic non-specific inflammatory bowel disease, and until now, therapeutic agents for UC including aminosalicylates, corticosteroids and immune inhibitors still cannot exert satisfied effects on patients. In recent years, Chinese medicines suggest the advantages of alleviating symptoms and signs, decreasing side-effects and recurrence, whose one of mechanisms is related to regulation of NF-κB pathway. In this review, we categorize Chinese medicines according to their traditional therapeutic functions, and summarize the characteristics of Chinese medicines targeting NF-κB pathway in UC treatment. It indicates that 85 kinds of Chinese medicines' compounds and formulae can directly act on NF-κBp65; while 58 Chinese medicines' ingredients and formulae indirectly suppress NF-κBp65 by regulation of its upstream or other related pathways. Moreover, by the analysis of Chinese medicines' category based on their traditional functions, we conclude the category of dampness-drying and detoxificating medicine targeting NF-κB pathway accounts for primary status for amelioration of UC. Simultaneously, this review also contributes to the choices of Chinese medicine category and provides curative potential of Chinese medicines for clinical UC treatment.

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“…Протиалергійний прояв кормової добавки ми відстежували за динамікою еозинофілів і станом тварин (свербіж, розчоси) й отримали позитивні результати. Вплив складників кормової добавки попередньо вивчили багато дослідників виявивши їх антитоксичну та протизапальну, нейропротекторну та гепатопротекторну дію (Tanideh et al, 2016;Dong et al, 2018).…”

Section: обговоренняunclassified

Efficiency of use of feed additives of plant origin «Phytovit» for the dogs

Sapko¹

2019

TAVM

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The application of the feed additives for nutrition correction, as well as the prophylaxis of any problems with health of the animals, is becoming more actual among veterinary professionals and owners of the animals. The effectiveness of the application of the feed additives «Phytovit» was established by analysis of the clinical state of the animals, clinical and biochemical indices of the dog blood. The animals were active throughout the observation period (4 weeks), they responded well to sound and light irritants; respiratory disorders, disorders in urination and defecation were not observed. In the dogs, beginning with the second week of the experiment, was found an improvement in appetite, general condition of skin and woolen cover (disappearance of dandruff-after a week of application, appearance of gloss and decrease of wool loss) relative to control. It was determined, that on the 14 th day of the experiment in the blood of the dogs of all experimental groups, the content of total hemoglobin increased an average by 8.5 % relative to the control level of the index. It was found, that the content of total protein, total calcium and inorganic phosphorus increased more markedly since 14 day of the experiment. It was established, that the level of serum enzymatic activity of Alanine aminotransferase (ALT) in the serum of blood of the animals in all experimental groups during the experiment gradually increased relative to the control, on the average in 1.2 (I); 1.3 (II); 1.3 (III); 1.4 (IV) and 1.4 (V) times (P ≤ 0.05). It is established, that feed additives in the recommended doses are not only harmless but also effective, because in accordance with the results of clinical and biochemical investigations of the blood of the dogs have been registered improvements in the assimilation of nutrients of feed, in particular-protein, macro-nutrients, fatsoluble vitamins, indicating their reduction of metabolic reactions in their organism.

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Corni Fructus: a review of chemical constituents and pharmacological activities

Cited by 94 publications

References 67 publications

Cornus mas L. Stones: A Valuable by-Product as an Ellagitannin Source with High Antioxidant Potential

Cornus mas L. Stones: A Valuable by-Product as an Ellagitannin Source with High Antioxidant Potential

Targeting NF-κB pathway for treating ulcerative colitis: comprehensive regulatory characteristics of Chinese medicines

Efficiency of use of feed additives of plant origin «Phytovit» for the dogs

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