Involvement of Interferon‐γ + 874A/T Polymorphism in the Pathogenesis of and Therapeutic Response to Immune Thrombocytopenia

Abstract

Background Immune thrombocytopenia (ITP) is an autoimmune disease characterized by symptoms of thrombocytopenia and bleeding due to production of autoantibodies against platelets. Recently, the occurrence of polymorphisms has been identified as one of the main causes of disease onset. Methods To conduct this study, we recruited 140 patients and control individuals with no history of platelet loss. After collection of specimens, the prevalence of interferon-γ polymorphism was evaluated using the allele-specific oligonucleotide–polymerase chain reaction (ASO-PCR) technique and confirmed by sequencing techniques. Results The results showed that the frequency of the AA genotype was higher in the control group, compared with patients with ITP; however, in the acute and chronic groups, the frequency of the AT genotype was higher than that of the AA genotype. We also discovered that there was no significant correlation between platelet counts before and after treatment, nor in its related parameters with interferon (IFN)–γ polymorphism. Conclusion rs2430561 does not seem to have any role in ITP pathogenesis and treatment response.

Effect of Helicobacter Pylori eradication on patients with ITP: a meta-analysis of studies conducted in the Middle East

“…These auto-antibody-coated platelets are cleared by macrophages of the reticuloendothelial system (RES), which leads to increased destruction of platelets, and increased risk of bleeding [7]. Similar to other autoimmune disorders, ITP is subject to certain effective factors, including genetic factors such as mutations in human leukocyte antigens (HLAs) and polymorphisms of interferon-γ [10][11][12]. In addition to genetic factors, other factors, such as H. pylori infection, are presumed to be associated with the initiation of ITP and the response of patients to therapy.…”