Involvement of inferior turbinate mucosa in chronic sinusitis – localization of T‐cell subset

Grevers, Gerhard; Klemens, A.; Menauer, F.; Sturm, C.

doi:10.1034/j.1398-9995.2000.00411.x

Cited by 11 publications

(10 citation statements)

References 29 publications

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“…A growing literature suggests that both of these diseases are characterized by activation of T cells and epithelial cells (52,53). Activated T cells are widely believed to be central orchestrating cells, and interactions between airway epithelial cells and T cells are likely to be important in the pathogenesis of asthma and CRS.…”

Section: Discussionmentioning

confidence: 99%

Constitutive and Inducible Expression of B7 Family of Ligands by Human Airway Epithelial Cells

Kim

Myers

Chen

et al. 2005

Am J Respir Cell Mol Biol

131

127

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Activated T cells have been implicated in chronic rhinosinusitis (CRS) and asthma and physically interact with epithelial cells in the airways. We now report that human airway epithelial cells display significant constitutive cell-surface expression of costimulatory ligands, B7-H1, B7-H2, B7-H3, and B7-DC. Expression of B7-H1 and B7-DC was selectively induced by stimulation of either BEAS2B or primary nasal epithelial cells (PNEC) with interferon (IFN)-gamma (100 ng/ml). The combination of IFN-gamma and tumor necrosis factor-alpha (100 ng/ml) selectively induced expression better than IFN-gamma alone. Fluticasone treatment (10(-7) M) reduced the baseline expression and inhibited the induction of B7-H1 and B7-DC in BEAS2B cells. In vitro exposure of PNEC to IFN-gamma also resulted in selective induction of B7-H1 and B7-DC. Monoclonal antibody blockade of B7-H1 or B7-DC enhanced IFN-gamma expression by purified T cells in co-culture experiments, suggesting that these two B7 homologs inhibit T cell responses at the mucosal surface. Immunohistochemical staining of human sinonasal surgical tissue confirmed the presence of B7-H1, B7-H2, and B7-H3 in the epithelial cell layer, especially in samples from patients diagnosed with Samter's Triad, a severe form of CRS. Real-time PCR analysis of sinonasal tissue revealed elevated levels of B7-H1 and B7-DC in CRS compared with controls. These results demonstrate that epithelial cells express functional B7 costimulatory molecules and that expression of selected B7 family members is inducible in vitro and in vivo. Epithelial B7 homologs could play a role in regulation of lymphocytic activity at mucosal surfaces.

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Section: Discussionmentioning

confidence: 99%

Constitutive and Inducible Expression of B7 Family of Ligands by Human Airway Epithelial Cells

Kim

Myers

Chen

et al. 2005

Am J Respir Cell Mol Biol

131

127

View full text Add to dashboard Cite

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“…The condition reported here was most likely caused by chronic sinusitis, which is known to occur in other hominoids, including humans, chimpanzees, and orangutans (Cambre et al 1995;Dumonceaux et al 1997). In contrast, even though nasal conchae can be involved in chronic sinusitis (Grevers et al 2000), the left inferior nasal concha in this specimen was probably lost postmortem.…”

Section: Discussionmentioning

confidence: 67%

Maxillary sinus atelectasis in a wild born gibbon (Hylobates moloch)

Koppe

Röhrer-Ertl²,

Breier

et al. 2005

Primates

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In a mixed sex sample of ten adult gibbon (Hylobates moloch) skulls, one cranium of a male with maxillary sinus atelectasis of the left side was identified. While external inspection revealed a slight drop of the left orbital floor, serial coronal computer tomography (CT) scans show characteristic changes of the left maxillary sinus and its surrounding structures. In addition to the sunken orbital floor, radiological features of the specimen include an inward bowing of the medial sinus wall, sinus opacification, and a reduction in maxillary sinus size to a slit-like cavity, which suggest a diagnosis of silent sinus syndrome. This report is the first, to our knowledge, of maxillary sinus atelectasis in a non-human primate. This finding is valuable for the understanding of the pathogenesis and etiology of maxillary sinus atelectasis. At the same time, however, paleoanthropologists and primatologists may refer to this information when dealing with the interpretation of maxillary sinus pneumatization of partially broken archaeological and fossil skulls.

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“…Highest levels of IL-8 and the highest percentages of lavage neutrophilia were seen in subjects classified as "nonallergic." In contrast, patients with chronic rhinosinusitis and associated allergic rhinitis had a modestly increased percentage of neutrophils and elevated IL-8 levels in the lavage fluid [30,31]. In a related study [32], increases in IL-8 were found by quantitative competitive PCR in sinus tissue obtained at the time of sinus surgery.…”

Section: Discussionmentioning

confidence: 91%

“…Infiltrating lymphocytes, about 40 % of which are T-cells, are an important component of the mononuclear infiltrate. CD8+ cells (suppressor/cytotoxic T-cells) seem to be more frequent than CD4+ cells (helper T-cells) [31].…”

Section: Discussionmentioning

confidence: 99%