Chronic rhinosinusitis ? need for further classification?

Rudack, Claudia; Sachse, F.; Alberty, J.

doi:10.1007/s00011-003-1232-2

Cited by 29 publications

(29 citation statements)

References 26 publications

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“…From a pathophysiological point of view, CMRS is due to a temporary and reversible mucociliary dyskinesia [11], which could be favoured by several factors: gastroesophageal reflux disease [12], atmospheric pollution [13], smoking [14], nasosinusal polyposis [15], arterial hypertension [15], dental infections, anatomic malformations such as septal deviations, concha bullosa, allergic reactions, and immune deficits [16–20]. Odontogenic CMRS occurs when the Schneiderian membrane is irritated or perforated, as a result of a dental infection, maxillary trauma, foreign body into the sinus, maxillary bone pathology, the placing of dental implants in the maxillary bone, supernumerary teeth, periapical granuloma, inflammatory keratocyst, or dental surgery like dental extractions or orthognathic osteotomies [3, 21]. Among the CMRS induced by foreign bodies, one might distinguish between exogenous or, less frequently, endogenous foreign bodies.…”

Section: Introductionmentioning

confidence: 99%

“…CMRS is clinically characterised by a variable association of symptoms including anterior or posterior, unilateral or sometimes bilateral discharge (purulent, watery, or mucoid), sinus or dental pain, nasal obstruction, hypo- or anosmia facial headaches that intensify in the evening while bending, halitosis, and occasionally coughing [17]. Even if there is no significant difference between classic and odontogenic CMR, anterior discharge, sinus pain, nagging pain of the upper teeth of the damaged side that increases during occlusion and tooth mobilisation, and halitosis seem to be more frequent in the latter [21, 25]. Percussion of the causal tooth may reveal an abnormal sensitivity, unless endodontic filling has been performed.…”

Section: Introductionmentioning

confidence: 99%

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Chronic Maxillary Rhinosinusitis of Dental Origin: A Systematic Review of 674 Patient Cases

Lechien

Filleul

Araujo

et al. 2014

International Journal of Otolaryngology

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Objectives. The aim of this systematic review is to study the causes of odontogenic chronic maxillary rhinosinusitis (CMRS), the average age of the patients, the distribution by sex, and the teeth involved. Materials and Methods. We performed an EMBASE-, Cochrane-, and PubMed-based review of all of the described cases of odontogenic CMRS from January 1980 to January 2013. Issues of clinical relevance, such as the primary aetiology and the teeth involved, were evaluated for each case. Results. From the 190 identified publications, 23 were selected for a total of 674 patients following inclusion criteria. According to these data, the main cause of odontogenic CMRS is iatrogenic, accounting for 65.7% of the cases. Apical periodontal pathologies (apical granulomas, odontogenic cysts, and apical periodontitis) follow them and account for 25.1% of the cases. The most commonly involved teeth are the first and second molars. Conclusion. Odontogenic CMRS is a common disease that must be suspected whenever a patient undergoing dental treatment presents unilateral maxillary chronic rhinosinusitis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chronic Maxillary Rhinosinusitis of Dental Origin: A Systematic Review of 674 Patient Cases

Lechien

Filleul

Araujo

et al. 2014

International Journal of Otolaryngology

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“…The more commonly accepted hypothesis proposes that CRS with polyps represents the most advanced, end stage form of the disease. The alternative theory proposes that polyposis is a distinct entity resulting from separate pathologic processes [9]. Further work at the molecular level is necessary to resolve this question, but the common thread that links all forms of CRS is persistent mucosal inflammation.…”

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confidence: 99%

Chronic Rhinosinusitis and Olfactory Dysfunction

Raviv

Kern²

2006

Taste and Smell

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Chronic rhinosinusitis encompasses a group of disorders characterized by inflammation of the mucosa of the nose and paranasal sinuses of at least 12 weeks' duration. In addition to nasal obstruction and discharge, chronic sinusitis is a common cause of olfactory dysfunction. However, smell loss is often overlooked in the clinical setting of sinusitis, with attention instead focused on the respiratory complaints of nasal obstruction, hypersecretion, and facial pressure and pain. Olfactory dysfunction can result in problems including safety concern, hygiene matters, appetite disorders, and changes in emotional and sexual behavior. Although smell loss related to sinonasal disease is probably the most treatable form of olfactory dysfunction, most studies show that improved olfactory sensation in this setting is usually transient and incomplete.

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“…In consequence some authors describe CRS as the 'asthma of the upper airways' (2,5). In the establishment of nonallergic CRS, IL-8, which is generated by neutrophils and mucosal epithelia, has been reported to play a pivotal role (6). Tokushige et al proposed that IL-1 production by neutrophils induced the expression of the intercellular adhesion molecule (ICAM-1) on endothelial cells, leading to neutrophil infiltration in CRS (7).…”

Section: Introductionmentioning

confidence: 99%

Influence of interleukin-13 on β-catenin levels ineosinophilic chronic rhinosinusitis cell culture

Sauter¹,

Stern‐Straeter²,

Chang³

et al. 2008

Int J Mol Med

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Abstract. Chronic rhinosinusitis (CRS) is one of the most common chronic diseases. The etiology and classification of CRS, with and without nasal polyps, remain unclear. Eosinophils and their products are important in the pathophysiology of allergic diseases and in host immunity to certain organisms. Interleukin 13 (IL-13) plays a pivotal role in eosinophilic inflammation. The migration of epithelial cells requires permanent re-establishment of the intercellular connection. Intercellular connections are maintained by the modulation of adherens junctions consisting of an E-cadherin/ß-catenin complex. In our study we examined the eosinophilic and non-eosinophilic paranasal mucosa obtained from two patients undergoing functional endoscopic sinus surgery. Cell cultures were incubated with human recombinant IL-13 for up to 72 h and ß-catenin concentration was determined with ELISA techniques. Furthermore, immunostaining for ß-catenin was used for the semi-quantitative description of specimens. We were able to ascertain a significant increase in ß-catenin expression in the eosinophilic paranasal cell culture after IL-13 administration compared to the non-eosinophilic culture. Immunostaining for ß-catenin was restricted to the membrane of the cells. Concerning the increased mural expression of ß-catenin, we presume that a fibrotic reaction similar to asthma and chronic obstructive pulmonary disease occurs in patients suffering from CRS. Furthermore, ß-catenin overexpression might be responsible for mucosal thickening and IL-13 seems to be an important marker in eosinophilic CRS.

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Chronic rhinosinusitis ? need for further classification?

Abstract: Different types and quantities of inflammatory cells as well as different levels of inflammation support our hypothesis that there is need for further subdivision of chronic rhinosinusitis into two disease entities.

Cited by 29 publications

References 26 publications

Chronic Maxillary Rhinosinusitis of Dental Origin: A Systematic Review of 674 Patient Cases

Chronic Maxillary Rhinosinusitis of Dental Origin: A Systematic Review of 674 Patient Cases

Chronic Rhinosinusitis and Olfactory Dysfunction

Influence of interleukin-13 on β-catenin levels ineosinophilic chronic rhinosinusitis cell culture

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