Involvement of free radicals in cerebral vascular reperfusion injury evaluated in a transient focal cerebral ischemia model of rat

Nakashima, Masaya; Niwa, Masayuki; Iwai, Tomohiko

doi:10.1016/s0891-5849(98)00257-3

Cited by 110 publications

(53 citation statements)

References 41 publications

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“…MCI-186 has been reported to have neuroprotective effects in both hemispheric embolization and transient cerebral ischemia in rats. [19][20][21] In addition, post-treatment with WEAA delayed for 2 and 4 or 3 and 5 h after ischemia significantly prevented the progression of infarction after MCAO. The time between onset of ischemia and initiation of drug treatment is a critical factor in treating acute ischemic stroke: our results obtained by the study of therapeutic time window support the usefulness of WEAA in treating acute ischemic stroke.…”

Section: Discussionmentioning

confidence: 84%

Effects of Anemarrhena asphodeloides on Focal Ischemic Brain Injury Induced by Middle Cerebral Artery Occlusion in Rats

Hyun

et al. 2007

Biological & Pharmaceutical Bulletin

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Section: Discussionmentioning

confidence: 84%

Effects of Anemarrhena asphodeloides on Focal Ischemic Brain Injury Induced by Middle Cerebral Artery Occlusion in Rats

Hyun

et al. 2007

Biological & Pharmaceutical Bulletin

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“…In a relatively mild model of stroke (20 min of ischemia and 10 -90 min of reperfusion), oxypurinol produced improvements in cellular ATP levels (Phillis et al, 1995). It must also be mentioned that in some studies oxypurinol was without significant protective effects Nakashima et al, 1999), and the reasons for these differences between the outcome of these various studies are unclear.…”

Section: Therapeutic Effects Of Xanthine Oxidase Inhibitorsmentioning

confidence: 99%

Therapeutic Effects of Xanthine Oxidase Inhibitors: Renaissance Half a Century after the Discovery of Allopurinol

2006

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“…xygen free radicals contribute to brain injury during cerebral ischemia (1,2). Because of high levels of polyunsaturated lipids, nervous tissue is markedly sensitive to oxygen free radical damage.…”

mentioning

confidence: 99%

Dehydroepiandrosterone prevents oxidative injury induced by transient ischemia/reperfusion in the brain of diabetic rats.

et al. 2000

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Both chronic hyperglycemia and ischemia/reperfusion (IR) cause an imbalance in the oxidative state of tissues. Normoglycemic and streptozotocin (STZ)-diabetic rats were subjected to bilateral carotid artery occlusion for 30 min followed by reperfusion for 60 min. Rats had either been treated with dehydroepiandrosterone (DHEA) for 7, 14, or 21 days (2 or 4 mg/day per rat) or left untreated. Oxidative state, antioxidant balance, and membrane integrity were evaluated in isolated synaptosomes. IR increased the levels of reactive species and worsened the synaptic function, affecting membrane Na/K-ATPase activity and lactate dehydrogenase release in all rats. The oxidative imbalance was much severer when transient IR was induced in STZ-diabetic rats. DHEA treatment restored H 2 O 2 , hydroxyl radical, and reactive oxygen species to close to control levels in normoglycemic rats and significantly reduced the level of all reactive species in STZ-diabetic rats. Moreover, DHEA treatment counteracted the detrimental effect of IR on membrane integrity and function: the increase of lactate dehydrogenase release and the drop in Na/K-ATPase activity were significantly prevented in both normoglycemic and STZ-diabetic rats. The results confirm that DHEA, an adrenal steroid that is synthesized de novo by brain neurons and astrocytes, possesses a multitargeted antioxidant effect. They also show that DHEA treatment is effective in preventing both derangement of the oxidative state and neuronal damage induced by IR in experimental diabetes. Diabetes

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Involvement of free radicals in cerebral vascular reperfusion injury evaluated in a transient focal cerebral ischemia model of rat

Cited by 110 publications

References 41 publications

Effects of Anemarrhena asphodeloides on Focal Ischemic Brain Injury Induced by Middle Cerebral Artery Occlusion in Rats

Effects of Anemarrhena asphodeloides on Focal Ischemic Brain Injury Induced by Middle Cerebral Artery Occlusion in Rats

Therapeutic Effects of Xanthine Oxidase Inhibitors: Renaissance Half a Century after the Discovery of Allopurinol

Dehydroepiandrosterone prevents oxidative injury induced by transient ischemia/reperfusion in the brain of diabetic rats.

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