Involvement of FGF‐2 in the action of Emdogain^® on normal human osteoblastic activity

Abstract

Emdogain showing both stimulation of cell proliferation and inhibition of cell differentiation has been shown to increase FGF-2 expression in the mediation of prostaglandin E2 and to decrease MMP-1 mRNA expression through the activation of FGF-2. FGF-2 may underlie in the action of EMD on osteoblasts during periodontal regeneration.

Effects of Enamel Matrix Derivative on Bioactive Glass in Rat Calvarium Defects

“…59 EMD have influence bone metabolism through the activation of growth factor. 60 Takayama et al reported that EMD promoted the osteogenic differentiation of pluripotent mesenchymal cells. This effect was mediated by BMP-like molecules present in the EMD.…”

Enamel matrix protein derivatives: role in periodontal regeneration

“…The results indicated that EMD-enhanced proliferation and viability of human Saos-2 osteoblasts on sandblasted/acid-etched titanium implants is concentration-dependent. Treatment of osteoblasts with EMD significantly stimulated cell proliferation and fibroblast growth factor-2 expression but decreased alkaline phosphatase expression 42. It was also suggested that EMD may elicit its mitogenic signal through an EMD-specific tyrosine kinase receptor towards extracellular signal regulated kinase 1/2 43.…”

The Application of an Enamel Matrix Protein Derivative (Emdogain®) in Regenerative Periodontal Therapy: A Review

“…The results indicated that EMD-enhanced cell proliferation and viability of human SaOs 2 osteoblasts on sandblasted/acid-etched (SLA) titanium implants are concentration-dependent. Treatment of osteoblasts with EMD significantly stimulated cell proliferation and fibroblast growth factor-2 expression but decreased alkaline phosphatase expression [35] . It was also suggested that EMD may elicit its mitogenic signal through an EMD-specific receptor tyrosine kinase towards extracellular signal-regulated kinase 1/2 [36] .…”