Involvement of eosinophils in the anti-tumor response

Gatault, S.; Legrand, Fanny; Delbeke, Marie; Loiseau, Sylvie; Capron, Moníque

doi:10.1007/s00262-012-1288-3

Cited by 105 publications

(108 citation statements)

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“…Limited studies in mouse models suggested that eosinophils were involved in antitumor immunity (3). However, because of the strong disparity between human and mouse eosinophils (8,38), those results were not totally relevant to clinical situations.…”

Section: Discussionmentioning

confidence: 98%

“…E osinophils are multifunctional leukocytes that participate in innate and adaptive immune responses through the expression of various receptors and mediators (1). Although indirect, growing evidence supports the participation of eosinophils in antitumor immunity, notably in the context of colon cancer (2,3). Several epidemiological studies suggested a correlation between the presence of tumor-associated tissue eosinophilia (TATE) and colorectal carcinoma, and the correlation showed good prognostic value (4-7).…”

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confidence: 99%

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IL-18 Is Involved in Eosinophil-Mediated Tumoricidal Activity against a Colon Carcinoma Cell Line by Upregulating LFA-1 and ICAM-1

Gatault

Delbeke

Driss

et al. 2015

The Journal of Immunology

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Eosinophils are multifunctional leukocytes that are involved in innate and adaptive immune responses through the expression of various receptors and mediators. Previously, we showed that human eosinophils and T cells shared cytotoxic activities against tumor cells that involved the γ-δ TCR and cell–cell contact. In this study, we investigated the molecules involved in eosinophil–tumor cell interactions. Given the role of IL-18 in cell adhesion and in protecting against colon cancer, we evaluated its role in eosinophil-mediated cytotoxicity against Colo-205, a human colon carcinoma cell line. We found that human eosinophils exerted dose- and time-dependent tumoricidal activity against Colo-205 cells. Neutralization of IL-18 significantly reduced eosinophil-mediated Colo-205 apoptosis and inhibited cell–cell adhesion. Moreover, addition of rIL-18 led to upregulation of CD11a and ICAM-1 adhesion molecules, which were involved in the contact between eosinophils and Colo-205 cells. Our results indicated that IL-18 was involved in the eosinophil-mediated death of Colo-205 by facilitating contact between effector and target cells. These data underscored the involvement of an additional mediator in eosinophil-mediated antitumor cytotoxicity. Our findings support existing evidence that eosinophils could play a beneficial role in the context of colon cancer.

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Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 99%

IL-18 Is Involved in Eosinophil-Mediated Tumoricidal Activity against a Colon Carcinoma Cell Line by Upregulating LFA-1 and ICAM-1

Gatault

Delbeke

Driss

et al. 2015

The Journal of Immunology

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“…In mice, treatment with IgE monoclonal antibodies that were specific for a colorectal tumor antigen inhibited the growth of human colorectal tumor xenografts (6). Recruitment of eosinophils to allergic sites is a key feature of IgE-mediated immune reactions (7), and eosinophils may have important antitumor effects (8), including cytotoxic effects on colorectal cancer cells (9). Eosinophil infiltration of colorectal adenomas is common and is associated with smaller size and less aggressive characteristics (10).…”

Section: Introductionmentioning

confidence: 99%

Hay Fever and Asthma as Markers of Atopic Immune Response and Risk of Colorectal Cancer in Three Large Cohort Studies

Jacobs

Gapstur

Newton

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: In a previous analysis of 12 cancers in the Cancer Prevention Study II (CPS-II) cohort including follow-up from 1982-2000, having both hay fever and asthma was associated with lower colorectal cancer mortality. The combination of these allergic conditions may be a marker for allergy-related immune responses that could inhibit colorectal carcinogenesis.Methods: We examined the association of having both hay fever and asthma with colorectal cancer mortality among 1,023,191 participants in CPS-I, followed from 1959-1972, and 1,102,092 participants in CPS-II, now followed from 1982-2008. We also examined associations with colorectal cancer incidence among 174,917 participants in the CPS-II Nutrition Cohort, a subgroup of CPS-II followed from 1992-2007. During the followup, there were 5,644 colorectal cancer deaths in CPS-I, 13,558 colorectal cancer deaths in CPS-II, and 3,365 incident colorectal cancer cases in the CPS-II Nutrition Cohort. Cox proportional hazards regression was used to calculate multivariable-adjusted relative risks (RR) and 95% confidence intervals (CI).Results: RRs for colorectal cancer mortality associated with having both asthma and hay fever, compared with neither condition, were 0.90 (95% CI, 0.74-1.09) in CPS-I, 0.79 (95% CI, 0.69-0.91) in CPS-II, and 0.83 (95% CI, 0.74-0.92) when results from both cohorts were combined in a meta-analysis. The corresponding RR for colorectal cancer incidence in the CPS-II Nutrition Cohort was 0.90 (95% CI, 0.71-1.14).Conclusion: These results support an association between having both hay fever and asthma and modestly lower colorectal cancer mortality.Impact: Research examining other potential markers of allergy-related immune response in relation to colorectal cancer is warranted. Cancer Epidemiol Biomarkers Prev; 22(4); 661-9. Ó2013 AACR.

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“…27 There is mounting evidence that suggests that eosinophils and immunoglobulin E may play important roles in the protection against cancer development through activities associated with tumor cell cytotoxicity and tumor suppression. [28][29][30] Conversely, chronic inflammation increases the susceptibility of the affected organs to cancer, which may explain higher risks of lung cancer among patients with asthma and nasal cavity cancer among patients with allergic rhinitis. 8,17,31 Another explanation for the association between allergic disease and gastric cancer could be the inverse relationship between allergic disease and H. pylori infection, which is the most important risk factor for gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

Associations between Atopic Dermatitis and Risk of Gastric Cancer: A Nationwide Population-based Study

Kim

Lee

et al. 2018

Korean J Gastroenterol

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Background/Aims: Epidemiologic and clinical data indicate that allergies may be associated with reduced risks for several cancers; however, to date, only a few studies have examined the associations between allergies and gastric cancer. This study aimed to examine the associations between allergies and gastric cancer using a large population-based dataset. Methods: This cross-sectional study obtained data from the Korea National Health and Nutrition Examination Survey between 2010 and 2014, involving a total of 24,089 participants. The associations between allergies and gastric cancer were analyzed using univariable and multivariable logistic regression analyses with complex sampling, while adjusting for confounding factors that included age, sex, body mass index, smoking status, alcohol intake, and level of education. Results: Multivariable logistic regression analyses that were adjusted for the potential confounders determined that a history of allergic diseases tended to be associated with reduced risk of gastric cancer; however, this relationship was not statistically significant (any allergy: odds ratio [OR], 0.62; 95% confidence interval [CI], 0.34-1.12; atopic dermatitis: OR, 0.34; 95% CI, 0.50-1.72; allergic rhinitis: OR, 0.71; 95% CI, 0.34-1.46; asthma: OR, 0.44; 95% CI, 0.15-1.29). Multivariable analysis showed that a history of atopic dermatitis was associated with reduced risk of gastric cancer in men (OR, 0.16; 95% CI,. Conclusions: This findings of this study suggest that individuals with allergies tend to have a reduced risk of gastric cancer, without a statistically significant association. Furthermore, atopic dermatitis was associated with reduced risk of gastric cancer, particularly in men. (Korean J Gastroenterol 2018;71:38-44)

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Involvement of eosinophils in the anti-tumor response

Cited by 105 publications

References 50 publications

IL-18 Is Involved in Eosinophil-Mediated Tumoricidal Activity against a Colon Carcinoma Cell Line by Upregulating LFA-1 and ICAM-1

IL-18 Is Involved in Eosinophil-Mediated Tumoricidal Activity against a Colon Carcinoma Cell Line by Upregulating LFA-1 and ICAM-1

Hay Fever and Asthma as Markers of Atopic Immune Response and Risk of Colorectal Cancer in Three Large Cohort Studies

Associations between Atopic Dermatitis and Risk of Gastric Cancer: A Nationwide Population-based Study

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