Involvement of dopaminergic and cholinergic pathways in the induction of yawning and genital grooming by the aqueous extract of Saccharum officinarum L. (sugarcane) in rats

Gamberini, Maria Thereza; Gamberini, Maria Cristina; Nasello, Antonia G.

doi:10.1016/j.neulet.2014.10.027

Cited by 7 publications

(2 citation statements)

References 6 publications

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“…Numerous studies have shown that different agents such as several peptidergic hormones (Gispen and Isaacson, 1981;Isaacson et al, 1983;Jolles et al, 1979) and neurotransmitters, such as dopamine (Taylor et al, 2010;Pelosi et al, 2015;Homberg et al, 2002) and acetylcholine (Gamberini et al, 2012(Gamberini et al, , 2015a, induce grooming in rodents. The pharmacological inductions may show patterns of this behavior with specific topographies to the type of substance administered indicating that different neural mechanisms are involved in the regulation of different patterns of grooming (Bressers et al, 1995a).…”

Section: Discussionmentioning

confidence: 99%

“…The participation of cholinergic pathways in the induction and modulation of neural pathways in the development of grooming is well established (Gamberini et al, 2012(Gamberini et al, , 2015a. Actions related to blood pressure control are also attributed to acetylcholine, such as chronotropic and dromotropic negative responses from the activation of cholinergic M2 receptors present in cardiac cells (Nenasheva et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

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Pharmacological evaluation of the hydro-alcoholic extract of Campomanesia phaea fruits in rats

2020

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Campomanesia phaea (Myrtaceae), popularly known as cambuci, is one of several species of plants producing comestible fruits, largely used in human nutrition. Despite its consumption and economic potential, limited scientific research is available on the Campomanesia, especially those related to its therapeutic benefits. It is reported by traditional medicine the use of the plant in the treatment of different disorders, such as cardiovascular and nervous system disturbances. So, the aim of this study was to carry out the pharmacological evaluation of the hydro-alcoholic extract (HAE) of Campomanesia fruits in rats by screening consisting of tests: a) neuropharmacological observation, b) test on the cardiovascular system. The HAE, prepared from the extraction of fruits with water/ethanol, was concentrated and freeze-dried. Behavioral responses in rats were investigated in open field test and the cardiovascular actions were investigated by a register of indirect blood pressure and the register of spontaneous beating rate right atrium. The results revealed that HAE induced grooming, hypotension and bradycardia. So, this study identified an action on the central nervous system, represented by grooming, and a cardiovascular activity of Campomanesia. The hypotension, attributed in part to bradycardia, was not related to a cholinergic effect, discarding a possible cholinomimetic action of the plant that could justify both cardiovascular and central actions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pharmacological evaluation of the hydro-alcoholic extract of Campomanesia phaea fruits in rats

2020

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A review of sugarcane bagasse for second‐generation bioethanol and biopower production

Bezerra

Ragauskas

2016

Biofuels Bioprod Bioref

212

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Sugarcane bagasse is a large-volume agriculture residue that is generated on a ~540 million metric tons per year basis globally 1,2 with the top-three producing countries in Latin America being Brazil (~181 million metric ton yr −1 ), 3 Mexico (~15 million metric ton yr −1 ), 4 and Colombia (~7 million metric ton yr −1 ), 5 respectively. 6 Given sustainability concerns and the need to maximize the utilization of bioresources, the use of sugarcane bagasse is receiving signifi cant attention in biorefi ning applications, as it is a promising resource for the conversion to biofuels and biopower. This review provides a comprehensive review of bagasse and its chemical constituents and on-going research into its utilization as a feedstock for cellulosic ethanol and electricity generation.

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Comparing the Effects of Ferulic Acid and Sugarcane Aqueous Extract in In Vitro and In Vivo Neurotoxic Models

et al. 2018

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Molecules exhibiting antioxidant, neuroprotective, and regulatory properties inherent to natural products consumed by humans are gaining attention in biomedical research. Ferulic acid (FA) is a phenolic compound possessing antioxidant and cytoprotective properties. It is found in several vegetables, including sugarcane, where it serves as the main antioxidant component. Here, we compared the antioxidant and cytoprotective effects of FA with those of the total sugarcane aqueous extract (SCAE). Specifically, we assessed biochemical markers of cell dysfunction in rat cortical brain slices and markers of physiological stress in Caenorhabditis elegans upon exposure to toxins evoking different mechanisms of neurotoxicity, including direct oxidative stress and/or excitotoxicity. In rat cortical slices, FA (250 and 500 μM), but not SCAE (~ 270 μM of total polyphenols), prevented the loss of reductive capacity induced by the excitotoxin quinolinic acid (QUIN, 100 μM), the pro-oxidant agent ferrous sulfate (FeSO, 25 μM), and the dopaminergic pro-oxidant 6-hydroxydopamine (6-OHDA, 100 μM). In wild-type (N2) C. elegans, FA (38 mM) exerted protective effects on decreased survival induced by FeSO (15 mM) and 6-OHDA (25 mM), and the motor alterations induced by QUIN (100 mM), FeSO, and 6-OHDA. In contrast, SCAE (~ 13.5 mM of total polyphenols) evoked protective effects on the decreased survival induced by the three toxic agents, the motor alterations induced by FeSO, and the reproductive deficit induced by FeSO. In addition, FA was unable to reverse the decreased survival induced by all these toxins in the skn-1 strain (VC1772), which lacks the homolog of mammalian Nrf2, a master antioxidant gene. Altogether, our results suggest that (1) both FA and SCAE afford protection against toxic conditions, (2) not all the effects inherent to SCAE are due to FA, and (3) FA requires the skn-1 pathway to exert its protective effects in C. elegans.

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Involvement of dopaminergic and cholinergic pathways in the induction of yawning and genital grooming by the aqueous extract of Saccharum officinarum L. (sugarcane) in rats

Cited by 7 publications

References 6 publications

Pharmacological evaluation of the hydro-alcoholic extract of Campomanesia phaea fruits in rats

Pharmacological evaluation of the hydro-alcoholic extract of Campomanesia phaea fruits in rats

A review of sugarcane bagasse for second‐generation bioethanol and biopower production

Comparing the Effects of Ferulic Acid and Sugarcane Aqueous Extract in In Vitro and In Vivo Neurotoxic Models

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