Involvement of cholecystokinin receptor in the inhibition of gastrointestinal motility by oxytocin in ovariectomized rats

Wu, Chiu-Lung; Doong, Ming-Luen; Wang, Paulus S.

doi:10.1016/j.ejphar.2007.11.024

Cited by 25 publications

(29 citation statements)

References 49 publications

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“…In addition to the presence of OTRs in adipocytes, the existence of OTRs elsewhere in the periphery, specifically the GI tract [59][60][61][152][153][154], the enteric nervous system [60,152], smooth muscle cells [61,152] and the vagus nerve [60], raises the possibility that circulating OT, in addition to actions at central OTRs [106,155,156], may also act in the periphery to reduce food intake. Systemic treatment with OTR antagonists that penetrate the blood brain barrier (BBB) increases food intake in mice and rats [32,123], effects that could possibly be mediated through both central and peripheral OTRs.…”

Section: Potential Role Of Peripheral Otrs In the Nodose Ganglia Or Gmentioning

confidence: 97%

Translational and therapeutic potential of oxytocin as an anti-obesity strategy: Insights from rodents, nonhuman primates and humans

Blevins

Baskin

2015

Physiology & Behavior

125

100

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The fact that more than 78 million adults in the US are considered overweight or obese highlights the need to develop new, effective strategies to treat obesity and its associated complications, including type 2 diabetes, kidney disease and cardiovascular disease. While the neurohypophyseal peptide oxytocin (OT) is well recognized for its peripheral effects to stimulate uterine contraction during parturition and milk ejection during lactation, release of OT within the brain is implicated in prosocial behaviors and in the regulation of energy balance. Previous findings indicate that chronic administration of OT decreases food intake and weight gain or elicits weight loss in diet-induced obese (DIO) mice and rats. Furthermore, chronic systemic treatment with OT largely reproduces the effects of central administration to reduce weight gain in DIO and genetically obese rodents at doses that do not appear to result in tolerance. These findings have now been recently extended to more translational models of obesity showing that chronic subcutaneous or intranasal OT treatment is sufficient to elicit body weight loss in DIO nonhuman primates and pre-diabetic obese humans. This review assesses the potential use of OT as a therapeutic strategy for treatment of obesity in rodents, nonhuman primates, and humans, and identifies potential mechanisms that mediate this effect.

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Section: Potential Role Of Peripheral Otrs In the Nodose Ganglia Or Gmentioning

confidence: 97%

Translational and therapeutic potential of oxytocin as an anti-obesity strategy: Insights from rodents, nonhuman primates and humans

Blevins

Baskin

2015

Physiology & Behavior

125

100

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“…Estradiol (E 2 ) treatment inhibits gastric emptying in Ovx rats (Wu et al 2002(Wu et al , 2008. This study also demonstrated that E 2 and a combination of E 2 and progesterone inhibit gastric emptying, but progesterone alone enhances gastric emptying in Ovx rats (Chen et al 1995).…”

Section: Discussionmentioning

confidence: 54%

“…Cholecystokinin (CCK), a 33 amino acid peptide extracted from porcine intestine (Jorpes & Mutt 1966), inhibits gastric emptying in animals (Debas et al 1975, Wu et al 2008 and humans (Konturek et al 1990) but has also been reported to stimulate colonic transit in vivo (Dinoso et al 1973, Harvey & Read 1973. The biological actions of CCK are mediated by two types of receptors, CCK 1 and CCK 2 (Noble et al 1999).…”

Section: Introductionmentioning

confidence: 99%

Human chorionic gonadotropin regulates gastric emptying in ovariectomized rats

Seow¹,

Lee²,

Doong³

et al. 2012

Journal of Endocrinology

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Prolongation of gastrointestinal transit resulting in nausea and vomiting in pregnancy (NVP) is the most common phenomenon during the first trimester of pregnancy. Increased human chorionic gonadotropin (hCG) concentration during the first trimester is the most likely cause of NVP. The aim of this study was to investigate the effect of hCG on gastrointestinal transit and plasma concentrations of cholecystokinin (CCK) in ovariectomized (Ovx) rats. I.p. injection of hCG was used to evaluate the dose effect of hCG on gastrointestinal transit in Ovx rats. The CCK antagonist lorglumide was used to clarify the role of CCK in regulating gastrointestinal transit. Gastrointestinal transit was assessed 15 min after intragastric gavage of a mixture of 10% charcoal and Na 2 51 CrO 4 (0.5 mCi/ml). After i.p. administration of hCG, gastric emptying was inhibited in Ovx rats, but intestinal transit was not affected. Plasma CCK concentrations were increased in a dose-dependent manner after hCG treatment, and gastric emptying showed a significant negative correlation with CCK concentrations (PZ0.01, r 2 ZK0.5104). Peripheral administration (i.p.) of lorglumide, a selective CCK 1 receptor antagonist, attenuated the hCG-induced inhibition of gastric emptying in Ovx rats, whereas central administration via the i.c.v. route did not. hCG treatment of Ovx rats inhibits gastric emptying in a dose-dependent manner via a peripheral mechanism of CCK hypersecretion and activation of CCK 1 receptors. Journal of EndocrinologyResearch K-M SEOW, J-L LEE and others hCG and gastric emptying 216:3 307-314

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“…OXT may exert its effect on the GI system through both central [47] and peripheral [48][49][50] mechanisms in rats. However, icv-injection of OXT, but not ip-injection, significantly improved delayed gastric emptying induced by acute restraint stress in mice [51] and rats [9].…”

Section: Discussionmentioning

confidence: 99%

Anti-Stress Effects of Transcutaneous Electrical Nerve Stimulation (TENS) on Colonic Motility in Rats

et al. 2012

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Involvement of cholecystokinin receptor in the inhibition of gastrointestinal motility by oxytocin in ovariectomized rats

Cited by 25 publications

References 49 publications

Translational and therapeutic potential of oxytocin as an anti-obesity strategy: Insights from rodents, nonhuman primates and humans

Translational and therapeutic potential of oxytocin as an anti-obesity strategy: Insights from rodents, nonhuman primates and humans

Human chorionic gonadotropin regulates gastric emptying in ovariectomized rats

Anti-Stress Effects of Transcutaneous Electrical Nerve Stimulation (TENS) on Colonic Motility in Rats

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