Involvement of BDNF in knee osteoarthritis: the relationship with inflammation and clinical parameters

Simão, Adriano Prado; Mendonça, Vanessa Amaral; Almeida, Tássio Málber de Oliveira; Santos, Sérgio Antunes; Gomes, Wellington Fabiano; Coimbra, Cândido Celso; Lacerda, Ana Cristina Rodrigues

doi:10.1007/s00296-013-2943-5

Cited by 47 publications

(24 citation statements)

References 15 publications

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“…The present study is the first to demonstrate that BDNF levels were increased in periodontal tissues from chronic periodontitis compared to healthy subjects. In agreement with our findings, BDNF was found in high levels in the plasma of patients with osteoarthritis [ 15 ] and in patients with rheumatoid arthritis [ 6 ]. While some authors [ 15 ] reported that BDNF levels were significantly correlated with self-reported pain, others [ 6 ] did not find association between BDNF and clinical parameters of arthritis.…”

Section: Discussionsupporting

confidence: 91%

Brain-Derived Neurotrophic Factor in Chronic Periodontitis

Corrêa

Pereira

Madeira

et al. 2014

Mediators of Inflammation

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Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophic factor family. Outside the nervous system, BDNF has been shown to be expressed in various nonneural tissues, such as periodontal ligament, dental pulp, and odontoblasts. Although a role for BDNF in periodontal regeneration has been suggested, a function for BDNF in periodontal disease has not yet been studied. The aim of this study was to analyze the BDNF levels in periodontal tissues of patients with chronic periodontitis (CP) and periodontally healthy controls (HC). All subjects were genotyped for the rs4923463 and rs6265 BDNF polymorphisms. Periodontal tissues were collected for ELISA, myeloperoxidase (MPO), and microscopic analysis from 28 CP patients and 29 HC subjects. BDNF levels were increased in CP patients compared to HC subjects. A negative correlation was observed when analyzing concentration of BDNF and IL-10 in inflamed periodontium. No differences in frequencies of BDNF genotypes between CP and HC subjects were observed. However, BDNF genotype GG was associated with increased levels of BDNF, TNF-α, and CXCL10 in CP patients. In conclusion, BDNF seems to be associated with periodontal disease process, but the specific role of BDNF still needs to be clarified.

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Section: Discussionsupporting

confidence: 91%

Brain-Derived Neurotrophic Factor in Chronic Periodontitis

Corrêa

Pereira

Madeira

et al. 2014

Mediators of Inflammation

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“…Conflicting results also exist for other pain conditions. Plasma levels of BDNF were higher in rheumatoid arthritis (RA) and in patients with osteoarthritis than in controls (48,49). In contrast, a large study found no differences in serum levels of BDNF between patients with chronic pain (n = 764) and controls (n = 882) (50).…”

Section: Discussionmentioning

confidence: 99%

Unaltered low nerve growth factor and high brain-derived neurotrophic factor levels in plasma from patients with fibromyalgia after a 15-week progressive resistance exercise

Jablochkova¹,

Bäckryd²,

Mannerkorpi³

et al. 2019

J Rehabil Med

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LAY ABSTRACTPatients with fibromyalgia have treatment-resistant chronic pain. More research is needed in order to understand how and why fibromyalgia develops. Neurotrophins, such as nerve growth factor and brain-derived neurotrophic factor, are involved in peripheral and central nervous system development of pain and hyperalgesia, but few studies have examined circulating nerve growth factor and brain-derived neurotrophic factor in fibromyalgia or have investigated whether exercise interventions affect the levels of these peptides. This study compared blood levels of nerve growth factor and brain-derived neurotrophic factor in fibromyalgia with those in healthy controls, and investigated the effect of exercise on these levels. Brain-derived neurotrophic factor levels were higher and levels of nerve growth factor were lower in fibromyalgia, compared with healthy controls. Clinical improvements were achieved following the exercise intervention, but the levels of brain-derived neurotrophic factor and nerve growth factor were not normalized.Background: The pathophysiology of fibromyalgia includes central and peripheral factors. Neurotro phins, such as nerve growth factor and brainderived neurotrophic factor, are involved in peripheral and central nervous system development of pain and hy peralgesia. Few studies have examined circulating nerve growth factor and brainderived neurotrophic factor in fibromyalgia or have investigated whether exercise interventions affect the levels of these pep tides. Objectives: To compare plasma levels of nerve growth factor and brainderived neurotrophic factor in fibromyalgia and in healthy controls, to investiga te correlations between levels of nerve growth fac tor, brainderived neurotrophic factor, and cytokines and clinical variables, and to investigate the effect of exercise on these levels. Subjects and methods: A total of 75 women with fibromyalgia participated in blood tests at baseline and after the 15week intervention, and 25 healthy controls participated at baseline. Patients were ran domized to a 15week progressive resistance exer cise intervention or a relaxation intervention. Results: Brainderived neurotrophic factor level was significantly higher (p < 0.001) and nerve growth factor level was significantly lower (p < 0.001) in fi bromyalgia than in healthy controls. Neither resis tance exercise nor relaxation interventions affec ted the levels of brainderived neurotrophic factor or nerve growth factor. No significant correlations were found between brainderived neurotrophic fac tor or nerve growth factor plasma levels in fibromy algia and cytokine levels or clinical variables. Conclusion: Changes in circulating nerve growth factor and brainderived neurotrophic factor levels may affect nociception/pain in fibromyalgia. Clinical improvements were achieved following the exercise intervention, but the levels of brainderived neuro trophic factor and nerve growth factor were not nor malized.

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“…16,17 In addition, immune mechanisms and inflammatory responses, including the serum brain-derived neurotrophic factor (BDNF), interferon gamma (IFN-g), serum programmed death 1 (PD-1), and T-cell Ig-and mucin-domain-containing molecule-3 (TIM-3), are believed to play a critical role in osteoarthritis (OA). 18,19 For example, Simão and colleagues 20 have found a significant positive correlation between plasma BDNF concentrations and self-reported pain (Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC]) in KOA patients. IFN-g signalling mediates spinal microglia activation driving neuropathic pain.…”

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confidence: 99%