Modulatory effects of different exercise modalities on the functional connectivity of the periaqueductal grey and ventral tegmental area in patients with knee osteoarthritis: a randomised multimodal magnetic resonance imaging study

Liu, Jiao; Chen, Lidian; Chen, Xiangli; Hu, Kun; Tu, Youxue; Lin, Miaomiao; Huang, Jia; Li, Weilin; Wu, Jinsong; Qiu, Zhijie; Zhu, Jingfang; Li, Ming; Park, Joel; Wilson, Georgia; Lang, Courtney; Xie, Guanli; Tao, Jing; Kong, Jian

doi:10.1016/j.bja.2019.06.017

Cited by 61 publications

(101 citation statements)

References 71 publications

(58 reference statements)

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“…Eleven trials included healthy participants only [ 17 , 20 , 22 , 30 , 33 , 36 , 37 , 39 , 49 , 55 , 60 ], and the remaining 36 included participants with a variety of physical and mental health conditions [ 4 , 6 , 7 , 18 , 19 , 21 , 23 – 29 , 31 , 32 , 34 , 35 , 38 , 40 – 48 , 50 – 54 , 56 – 59 ].…”

Section: Resultsmentioning

confidence: 99%

The Safety of Baduanjin Exercise: A Systematic Review

Fang

Zhang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Objectives. Baduanjin exercise is a form of Qigong exercise therapy that has become increasingly popular worldwide. The aims of the current systematic review were to summarize reported adverse events potentially associated with Baduanjin exercise based on currently available literature and to evaluate the quality of the methods used to monitor adverse events in the trials assessed. Methods. The English databases PubMed, Cochrane library, and EMbase were searched from inception to October 2020 using the keywords “Baduanjin” or “eight session brocade.” Only studies that included Baduanjin exercise therapy were included. Results. Forty-seven trials with a total of 3877 participants were included in this systematic review. Twenty-two studies reported protocols for monitoring adverse events, and two studies reported the occurrence of adverse events during training. The adverse events reported included palpitation, giddiness, knee pain, backache, fatigue, nervousness, dizziness, shoulder pain, chest tightness, shortness of breath, and muscle ache. Conclusions. Only two studies reported adverse events that were potentially caused by Baduanjin exercise. Adverse events related to Baduanjin exercise in patients with chronic fatigue syndrome may include muscle ache, palpitation, giddiness, knee pain, backache, fatigue, nervousness, dizziness, shoulder pain, chest tightness, and shortness of breath. Further studies conducted in accordance with the Consolidated Standards of Reporting Trials statement guideline incorporating monitoring of adverse events are recommended. Additional clinical trials in which Baduanjin exercise is used as a main intervention are needed, and further meta-analysis may be required to assess its safety and reach more informed conclusions in this regard in the future.

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Section: Resultsmentioning

confidence: 99%

The Safety of Baduanjin Exercise: A Systematic Review

Fang

Zhang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…For instance, studies have shown that dopamine, a key neurotransmitter of reward, is involved in pain modulation [34], and opioids are central to endogenous pain inhibition and are also involved in reward processing [24]. In a recent study, we found that exercise can simultaneously modulate functional connectivity of the descending pain modulation pathway and the reward/motivation system to relieve knee osteoarthritis pain [35].…”

Section: Introductionmentioning

confidence: 91%

Acupuncture Treatment Modulates the Connectivity of Key Regions of the Descending Pain Modulation and Reward Systems in Patients with Chronic Low Back Pain

Ortiz

Gollub

et al. 2020

JCM

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Chronic low back pain (cLBP) is a common disorder with unsatisfactory treatment options. Acupuncture has emerged as a promising method for treating cLBP. However, the mechanism underlying acupuncture remains unclear. In this study, we investigated the modulation effects of acupuncture on resting state functional connectivity (rsFC) of the periaqueductal gray (PAG) and ventral tegmental area (VTA) in patients with cLBP. Seventy-nine cLBP patients were recruited and assigned to four weeks of real or sham acupuncture. Resting state functional magnetic resonance imaging data were collected before the first and after the last treatment. Fifty patients completed the study. We found remission of pain bothersomeness in all treatment groups after four weeks, with greater pain relief after real acupuncture compared to sham acupuncture. We also found that real acupuncture can increase VTA/PAG rsFC with the amygdala, and the increased rsFC was associated with decreased pain bothersomeness scores. Baseline PAG-amygdala rsFC could predict four-week treatment response. Our results suggest that acupuncture may simultaneously modulate the rsFC of key regions in the descending pain modulation (PAG) and reward systems (VTA), and the amygdala may be a key node linking the two systems to produce antinociceptive effects. Our findings highlight the potential of acupuncture for chronic low back pain management.

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“…PE is a first-choice treatment in the management of CMP [9][10][11][12][13][14], and PE in particular has proven to be a useful tool in the treatment of CMP. Furthermore, certain modalities of PE promote neurogenesis, neuroplastic changes at the brain level [54][55][56][57][58][59], and descending inhibitory pain pathways activation [60,61]. Thus, a therapeutic approach based on the combination of PNE and PE can improve quality of life and disability, decreasing the pain intensity of patients with CMP and those suffering from chronic spinal pain (CSP).…”

Section: Introductionmentioning

confidence: 99%

Pain Neuroscience Education and Physical Therapeutic Exercise for Patients with Chronic Spinal Pain in Spanish Physiotherapy Primary Care: A Pragmatic Randomized Controlled Trial

Galán-Martín

Montero-Cuadrado²,

Lluch-Girbés

et al. 2020

JCM

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Chronic musculoskeletal pain affects more than 20% of the population, leading to high health care overload and huge spending. The prevalence is increasing and negatively affects both physical and mental health, being one of the leading causes of disability. The most common location is the spine. Most treatments used in the Public Health Services are passive (pharmacological and invasive) and do not comply with current clinical guidelines, which recommend treating pain in primary care (PC) with education and exercise as the first-line treatments. A randomized multicentre clinical trial has been carried out in 12 PC centres. The experimental group (EG) conducted a program of pain neuroscience education (6 sessions, 10 h) and group physical exercise with playful, dual-tasking, and socialization-promoting components (18 sessions in 6 weeks, 18 h), and the control group performed the usual physiotherapy care performed in PC. The experimental treatment improved quality of life (d = 1.8 in physical component summary), catastrophism (d = 1.7), kinesiophobia (d = 1.8), central sensitization (d = 1.4), disability (d = 1.4), pain intensity (d = 3.3), and pressure pain thresholds (d = 2). Differences between the groups (p < 0.001) were clinically relevant in favour of the EG. Improvements post-intervention (week 11) were maintained at six months. The experimental treatment generates high levels of satisfaction.

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Modulatory effects of different exercise modalities on the functional connectivity of the periaqueductal grey and ventral tegmental area in patients with knee osteoarthritis: a randomised multimodal magnetic resonance imaging study

Cited by 61 publications

References 71 publications

The Safety of Baduanjin Exercise: A Systematic Review

The Safety of Baduanjin Exercise: A Systematic Review

Acupuncture Treatment Modulates the Connectivity of Key Regions of the Descending Pain Modulation and Reward Systems in Patients with Chronic Low Back Pain

Pain Neuroscience Education and Physical Therapeutic Exercise for Patients with Chronic Spinal Pain in Spanish Physiotherapy Primary Care: A Pragmatic Randomized Controlled Trial

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