Involvement of Aromatic Metabolites in the Pathogenesis of Septic Shock

Белобородова, Н. В.; Sarshor, Yu. N.; Bedova, Aleksandra; Chernevskaya, Ekaterina; Pautova, Alisa

doi:10.1097/shk.0000000000001064

Cited by 32 publications

(35 citation statements)

References 31 publications

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“…Furthermore, one study of patients with community acquired pneumonia admitted to the ICU, reported that NT‐proBNP was significantly higher in patients with septic shock, compared to patients without septic shock. While patients with non‐infectious shock were excluded from the study, the authors did not clarify whether patients without septic shock suffered from sepsis or severe sepsis …”

Section: Resultsmentioning

confidence: 99%

“…While patients with non-infectious shock were excluded from the study, the authors did not clarify whether patients without septic shock suffered from sepsis or severe sepsis. 58 In contrast to these results, a study by Hämäläinen et al, conducted in patients with neutropenic fever, demonstrated that serial NT-proBNP measurements could not predict the development of severe sepsis. 49…”

Section: Ability Of Brain Natriuretic Peptides To Distinguish Betwementioning

confidence: 89%

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The utility of brain natriuretic peptides in septic shock as markers for mortality and cardiac dysfunction: A systematic review

et al. 2019

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Objective To conduct a systematic review evaluating the utility of brain natriuretic peptide (BNP) and N‐terminal proBNP (NT‐proBNP) as biomarkers in adult patients with septic shock. Materials and Methods Pubmed/Medline databases were searched from inception to November 2018 using the search terms: (septic[Title/Abstract] AND shock[Title/Abstract]) AND bnp[Title/Abstract]) and (septic[Title/Abstract]) AND shock[Title/Abstract]) AND natriuretic[Title/Abstract]). No restriction was applied regarding date of publication. Comparative observational studies evaluating BNP and NT‐proBNP in patients with septic shock aged ≥18 years were eligible for inclusion. Bibliographies from the extracted articles were also reviewed to identify additional relevant publications. Results In total, 46 studies met all eligibility criteria and were included. A strong body of literature has demonstrated that in patients with septic shock, increased values of BNP and NT‐proBNP are associated with increased mortality. An increase from baseline BNP values has also been associated with increased mortality, whereas decreases from baseline values are not related to worse outcome. Brain natriuretic peptides have also been associated with cardiac dysfunction in patients with sepsis. Moreover, BNP values have been found to be significantly elevated in septic shock, regardless of cardiac dysfunction, and have been used to distinguish between septic and cardiogenic shock. Furthermore, BNP and NT‐proBNP are significantly increased in patients with septic shock, compared to patients with sepsis and severe sepsis. Conclusions BNP and NT‐proBNP appear to be reliable predictors of outcome in septic shock.

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Section: Resultsmentioning

confidence: 99%

Section: Ability Of Brain Natriuretic Peptides To Distinguish Betwementioning

confidence: 89%

The utility of brain natriuretic peptides in septic shock as markers for mortality and cardiac dysfunction: A systematic review

et al. 2019

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“…It was shown that in vitro some sepsis-associated AMM in clinically significant concentrations can inhibit the phagocytic activity of neutrophils [17]; cause mitochondrial dysfunction [18]; influence on platelet aggregation [19]; reduce tyrosine hydroxylase activity, thus limiting the synthesis of catecholamines; and participate in the pathogenesis of septic shock [20]. Numerous data obtained in vitro allow us to hypothesize that AMM acts as signaling molecules ( Figure 3).…”

Section: The Gut Microbial Metabolites In the Pathogenesis Of Sepsismentioning

confidence: 99%

“…It is impossible to exclude the presence of common signaling pathways, cell receptors, transmembrane transporters, and other mechanisms of humans and bacteria, as well as the direct participation of microbial metabolites in the pathogenesis of sepsis. Thus, today, we should not confine ourselves to studying eukaryotic cells while searching for new molecular mechanisms of sepsis-associated organ failure and septic shock [20]. We should consider and simulate experimental changes in the internal environment of a person that occur with a radical "restructuring" of the microbiome in seriously ill patients.…”

Section: The Gut Microbial Metabolites In the Pathogenesis Of Sepsismentioning

confidence: 99%

Microbiota-Oriented Diagnostics and Therapy in Sepsis: Utopia or Necessity?

Chernevskaya¹,

Белобородова²

2020

Infectious Process and Sepsis

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When diagnosing sepsis, it is common to look for pathogens, microbe's DNA, lipopolysaccharide (LPS), or host biomarkers while missing out on microbiota. The next-generation sequencing of 16S rRNA gene allowed characterizing the gut microbiota taxonomy and clarifying the gut microbial population being more complex than was previously thought. We suppose that significant disruption of the microbiota is an indicator of the major role it plays in sepsis. Serious metabolic disorders of the gut microbiota may contribute to an unfavorable outcome in septic patients. With the changes not only in the composition but also in the metabolic activity of the gut microbiota taken into account, the characteristics of the mechanisms of interactions in the "septic" microbiome will allow the advances in the optimization of the diagnostics and therapy of sepsis to be made.

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“…Важное значение играют ароматические микробные метаболиты (АММ) фенольной природы: например, ассоциированные с развитием септического шока и летальным исходом -пара-гидроксифенилуксусная кислота (п-ГФУК) [27,28], фенилмолочная (ФМК) и пара-гидроксифенилмолочная (п-ГФМК) кислоты [29].…”

Section: перспективы в нейрореабилитологииunclassified

Prospects for microbiota-oriented therapy in neurorehabilitology

Белобородова

Chernevskaya

Черневская³

2020

Physical and rehabilitation medicine, medical rehabilitation

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Intensive accumulation of data on the role of bacteria in complex regulatory mechanisms of the nervous system allows us to predict the transition to a new level in the treatment of brain dysfunctions. This problem-oriented article analyzes recent publications that reflect the relationship of changes in the profile of microbiota metabolites with the course and outcome of the disease in patients with central nervous system damage. Based on the results of biomarker monitoring in patients with prolonged neurorehabilitation in the Intensive care unit, the authors justify a metabolomic approach for correction in the microbiotagutbrain system.

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Involvement of Aromatic Metabolites in the Pathogenesis of Septic Shock

Abstract: AMM are involved in the pathogenesis of septic shock.

Cited by 32 publications

References 31 publications

The utility of brain natriuretic peptides in septic shock as markers for mortality and cardiac dysfunction: A systematic review

The utility of brain natriuretic peptides in septic shock as markers for mortality and cardiac dysfunction: A systematic review

Microbiota-Oriented Diagnostics and Therapy in Sepsis: Utopia or Necessity?

Prospects for microbiota-oriented therapy in neurorehabilitology

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