Involvement of adrenaline in diazepam-induced hyperglycemia in mice

Yamada, Jun; Sugimoto, Yukihiko; Noma, Toshiko

doi:10.1016/s0024-3205(00)00426-4

Cited by 7 publications

(10 citation statements)

References 10 publications

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“…The divergence between the present results and those reported for mice treated with diazepam (Yamada et al 2000) may be a reflection of the plasticity that surrounds peripheral adrenoceptors mediating glycogenolysis, as determined by differences in species, age, gender, fasting and type of precipitating stimulus (Erraji-Benchekroun et al 2005;Ishac and Kunos 1986;Kunos et al 1984). An assessment of the relative contribution of β 1 -and β 2 -adrenoceptors to PL-related glycogenolysis was obtained from a comparison of the effects of PRO-MEL and MET-MEL in preserving tissue glycogen.…”

Section: Discussioncontrasting

confidence: 92%

“…The use of IDX was suggested by a study in mice in which this α 2 -adrenoceptor antagonist was able to prevent hyperglycemia as a result of an increase in plasma epinephrine levels caused by diazepam (Yamada et al 2000). Since the present inability of IDX to protect against the loss of liver and gastrocnemius muscle glycogen parallels the results previously noted with the α 1 -adrenoceptor antagonist, phentolamine (PHE) in an identical animal model (Lau-Cam et al 1991), rules out the a significant role for α-adrenoceptors in glycogenolysis by PL.…”

Section: Discussionmentioning

confidence: 99%

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Attenuating effect of melatonin on pyridoxal-stimulated release of adrenomedullary catecholamines in the rat

Budhram

Lau‐Cam

2009

Life Sciences

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Section: Discussioncontrasting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Attenuating effect of melatonin on pyridoxal-stimulated release of adrenomedullary catecholamines in the rat

Budhram

Lau‐Cam

2009

Life Sciences

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“…We reported that administration of an another anxiolytic benzodiazepine diazepam induces hyperglycemia in mice. 21) On the contrary, our results suggest that buspirone may be effective in hyperglycemia in addition to anxiety.…”

Section: Fig 3 Effects Of 1-pp On Plasma Glucose and Serum Insulin contrasting

confidence: 55%

Inhibitory Effects of the 5-HT1A Receptor Agonist Buspirone on Stress-Induced Hyperglycemia in Mice: Involvement of Insulin and a Buspirone Metabolite, 1-(2-Pyrimidinyl)piperazine (1-PP)

Sugimoto

Takashima

Noma

et al. 2005

Biological & Pharmaceutical Bulletin

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Benzodiazepine derivatives are widely used for anxiety, by the facilitation of GABA neurotransmission. It is well known that serotonin (5-HT) is involved in several neurological functions.1) The 5-HT 1A receptor is related to emotion and the 5-HT 1A receptor agonists induce anxiolytic and antidepressant effects in humans and animals. 2,3) Buspirone is known to be a 5-HT 1A receptor agonist and is used to treat anxiety.2) Stress induces several neuroendocrinological effects such as activation of the hypothalamus-pituitary-adrenal (HPA) axis and elicits activation of sympathetic tone. 4,5) Hyperglycemic responses to stress are recognized as an index of the sympathetic nervous system. 4) Stress induces changes in emotion and mood. 5) Recently, it was reported that the 5-HT 1A receptor agonist might be effective for stress-induced behavioral depressant symptoms. 2)Previous reports demonstrated that 5-HT receptor is involved in glucose regulation. The 5-HT 1A receptor agonist 8-OH-DPAT elicits hyperglycemia in rats and mice.6,7) The 5-HT 1A receptor partial agonist buspirone and ipsapirone elevate the glucose levels of rats. 8,9) These effects of 5-HT 1A receptor agonists are considered due to facilitating adrenaline release from the adrenal medulla.10,11) However, there may be species differences in the effects of buspirone on glucose levels between rats and mice. We previously reported that buspirone did not elevate glucose levels of mice and it increases serum insulin levels.12) In addition, buspirone reduces glucose-induced hyperglycemia in mice by increasing insulin levels. 12)It is well known that stress elicits hyperglycemia and stress-induced hyperglycemia may be a factor in contributing to diabetes. 4,13) Since buspirone is available in stressed-patients with accompanying with anxiety, the possibility that buspirone may also suppress stress-induced hyperglycemia is postulated. However, it is not clear whether buspirone modifies stress-elevated hyperglycemia. In this paper, we examined the effects of buspirone on stress-induced hyperglycemia and involvement of insulin in the effects of buspirone. MATERIALS AND METHODS AnimalsMale ddY mice weighing 28-32 g were obtained from SLC Japan Inc (Japan). Mice were fed with free access to food and water and they were housed under a controlled 12-h/12-h light-dark cycle (light from 7:00 a.m. to 7:00 p.m.), with room temperature at 23Ϯ1°C and humidity at 55Ϯ5%. For experiments with glucose, mice were fasted for 20 h. The experimental procedure was approved by the Kobe Pharmaceutical University Animal Care and Use Committee.Drug Treatment Buspirone HCl, 1-(2-pyrimidinyl)-piperazine (1-PP) HCl were obtained from Sigma (U.S.A.). Drugs were dissolved in saline. Buspirone and 1-PP were injected s.c. 30 min before immobilization stress.Immobilization and Determination of Plasma Glucose and Insulin Levels Mice were restrained by placing in individual wire cages (3.5 cmϫ8.3 cmϫ2.3 cm). After immobilization for 15, 30, 60 and 120 min, mice were immediately decapitated and blood ...

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“…Same findings are also documented in this study as elevated haemoglycemic level with the use of diazepam as 0.5 mg/kg when administered intravenously. Increase in haemoglycemic values occurred as a result of stimulation of adrenoreceptors ultimately leading to reduced insulin secretion, stress hormones may also be one of the contributing factors [21].…”

Section: Discussionmentioning

confidence: 99%

Study on haemoglycemic effects of xylazine, diazepam and ketamine in surgically treated dogs

Khan¹,

Durrani²,

Aslam³

et al. 2014

IOSRJAVS

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Involvement of adrenaline in diazepam-induced hyperglycemia in mice

Cited by 7 publications

References 10 publications

Attenuating effect of melatonin on pyridoxal-stimulated release of adrenomedullary catecholamines in the rat

Attenuating effect of melatonin on pyridoxal-stimulated release of adrenomedullary catecholamines in the rat

Inhibitory Effects of the 5-HT1A Receptor Agonist Buspirone on Stress-Induced Hyperglycemia in Mice: Involvement of Insulin and a Buspirone Metabolite, 1-(2-Pyrimidinyl)piperazine (1-PP)

Study on haemoglycemic effects of xylazine, diazepam and ketamine in surgically treated dogs

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