Involvement of a mouse mammary tumor virus (MMTV) homologue in human breast cancer: Evidence for, against and possible causes of controversies

Amarante, Marla Karine; Pereira, Nathalia de Sousa; Vitiello, Glauco Akelinghton Freire; Watanabe, Maria Angélica Ehara

doi:10.1016/j.micpath.2019.03.021

Cited by 27 publications

(34 citation statements)

References 117 publications

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“…EBV infection alone is not sufficient to cause cancer but may lead to carcinogenesis in tandem with genetic and environmental factors [28]. In the case of breast cancer, there was early suspicion that breast cancer in humans may be driven in part by a mammary tumor virus [29]. While this is a known phenomenon in mice, no such virus has been conclusively identified in humans.…”

Section: Historical Relationships Between the Microbiome And Cancermentioning

confidence: 99%

The promise and challenge of cancer microbiome research

2020

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Many microbial agents have been implicated as contributors to cancer genesis and development, and the search to identify and characterize new cancer-related organisms is ongoing. Modern developments in methodologies, especially cultureindependent approaches, have accelerated and driven this research. Recent work has shed light on the multifaceted role that the community of organisms in and on the human body plays in cancer onset, development, detection, treatment, and outcome. Much remains to be discovered, however, as methodological variation and functional testing of statistical correlations need to be addressed for the field to advance.

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Section: Historical Relationships Between the Microbiome And Cancermentioning

confidence: 99%

The promise and challenge of cancer microbiome research

2020

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“…There is a need of combined studies on breast and cervical cancers because a causal relationship between human papillomavirus (HPV) and breast cancer has also been suggested, [56] and a review of twenty studies shows that nearly a quarter of breast carcinomas tested for HPV were of HPV positive. [57] Cervical precancer and breast cancer though share some common risk factors, such as hormonal contraceptive use, [58,59] there are some studies which showed that there exists no relation between both cancers [60][61][62][63][64][65] and some have proven the existence of a relationship between the two cancers.…”

Section: Discussionmentioning

confidence: 99%

Incidence and trends of breast and cervical cancers: A Joinpoint regression analysis

Labani

Asthana

Srivastava

et al. 2020

Indian Journal of Medical and Paediatric Oncology

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Background: Breast and cervical cancers are two major cancers affecting women's health. Breast cancer is the most invasive cancer, and cervical cancer is the fourth most leading cause of death among women. Analysis of updated incidence data and their trends would help policymakers in planning and organizing programs to reduce the burden. This study aims to present regional variations in recent years and study trends of both the cancers in India. Materials and Methods: For recent incidence rates of cervical and breast cancers, data were obtained from the National Cancer Registry Programme (NCRP) reports (2009-2011) for 25 registries and of 2012-2014 for 27 registries. Trends were studied for data obtained from different NCRP reports for the years 1982-2014 in six major registries. One in number of person who developed cancer and the annual Percentage change in incidence were calculated along with the trend analysis for both the cancers. The Joinpoint Regression Model was used for trend analysis. Results: The age-adjusted rate (AAR) of incidence of breast cancer in the South region was 36.

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“…[35][36][37][38] However, a few studies failed to detect the presence of these oncoviruses in human breast cancer as well as normal mammary tissues. [39][40][41] Based on previous reports depicting the role of HPVs, EBV, and MMTV-like virus in the initiation of various cancers, comprising breast, 19,30,[36][37][38][42][43][44][45] we explored the presence/co-presence of high-risk HPVs, EBV, and MMTV-like virus in TNBC samples in Croatian women.…”

Section: Introductionmentioning

confidence: 99%

Presence of high-risk HPVs, EBV, and MMTV in human triple-negative breast cancer

Gupta

Ulamec

Perić-Balja

et al. 2021

Human Vaccines & Immunotherapeutics

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Breast cancer, the most frequent disease amongst women worldwide, accounts for the highest cancerrelated mortality rate. Triple-negative breast cancer (TNBC) subtype encompasses ~15% of all breast cancers and lack estrogen, progesterone, and HER2 receptors. Although risk factors for breast cancer are well-known, factors underpinning breast cancer onset and progression remain unknown. Recent studies suggest the plausible role of oncoviruses including human papillomaviruses (HPVs), Epstein-Barr virus (EBV), and mouse mammary tumor virus (MMTV) in breast cancer pathogenesis. However, the role of these oncoviruses in TNBC is still unclear. In the current study, we explored the status of high-risk HPVs, EBV, and MMTV in a well-defined TNBC cohort from Croatia in comparison to 16 normal/non TNBC samples (controls) using polymerase chain reaction assay. We found high-risk HPVs and EBV present in 37/70 (53%) and 25/70 (36%) of the cases, respectively. The most common HPV types are 52, 45, 31, 58 and 68. We found 16% of the samples positive for co-presence of high-risk HPVs and EBV. Moreover, our data revealed that 5/70 (7%) samples are positive for MMTV. In addition, only 2/70 (3%) samples had copresence of HPVs, EBV, and MMTV without any significant association with the clinicopathological variables. While, 6/16 (37.5%) controls were positive for HPV (p = .4), EBV was absent in all controls (0/ 16, 0%) (p = .01). In addition, we did not find the co-presence of the oncoviruses in the controls (p > .05). Nevertheless, further investigations are essential to understand the underlying mechanisms of multipleoncogenic viruses' interaction in breast carcinogenesis, especially TNBC.

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Involvement of a mouse mammary tumor virus (MMTV) homologue in human breast cancer: Evidence for, against and possible causes of controversies

Cited by 27 publications

References 117 publications

The promise and challenge of cancer microbiome research

The promise and challenge of cancer microbiome research

Incidence and trends of breast and cervical cancers: A Joinpoint regression analysis

Presence of high-risk HPVs, EBV, and MMTV in human triple-negative breast cancer

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