The promise and challenge of cancer microbiome research

Manzoor, Sumeed; Doedens, Annemiek; Burns, Michael B.

doi:10.1186/s13059-020-02037-9

Cited by 28 publications

(22 citation statements)

References 216 publications

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“…S3 online). We also found that skin microbiomes of rainbow trout were not so similar between the present findings and those of others 29 , 31 compared to the gut microbiomes, although it should be also noted that many of other factors can also leads to different results 47 . Therefore, the microbial community of fish skin might be controlled by changing the microbial community in surrounding water in a closed system.…”

Section: Discussioncontrasting

confidence: 63%

Skin bacteria of rainbow trout antagonistic to the fish pathogen Flavobacterium psychrophilum

Takeuchi

Fujiwara-Nagata

Katayama

et al. 2021

Sci Rep

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Rainbow trout fry syndrome (RTFS) and bacterial coldwater disease (BCWD) is a globally distributed freshwater fish disease caused by Flavobacterium psychrophilum. In spite of its importance, an effective vaccine is not still available. Manipulation of the microbiome of skin, which is a primary infection gate for pathogens, could be a novel countermeasure. For example, increasing the abundance of specific antagonistic bacteria against pathogens in fish skin might be effective to prevent fish disease. Here, we combined cultivation with 16S rRNA gene amplicon sequencing to obtain insight into the skin microbiome of the rainbow trout (Oncorhynchus mykiss) and searched for skin bacteria antagonistic to F. psychrophilum. By using multiple culture media, we obtained 174 isolates spanning 18 genera. Among them, Bosea sp. OX14 and Flavobacterium sp. GL7 respectively inhibited the growth of F. psychrophilum KU190628-78 and NCIMB 1947T, and produced antagonistic compounds of < 3 kDa in size. Sequences related to our isolates comprised 4.95% of skin microbial communities, and those related to strains OX14 and GL7 respectively comprised 1.60% and 0.17% of the skin microbiome. Comparisons with previously published microbiome data detected sequences related to strains OX14 and GL7 in skin of other rainbow trout and Atlantic salmon.

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Section: Discussioncontrasting

confidence: 63%

Skin bacteria of rainbow trout antagonistic to the fish pathogen Flavobacterium psychrophilum

Takeuchi

Fujiwara-Nagata

Katayama

et al. 2021

Sci Rep

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“…In recent years, a lot of evidence has shown that microbiome is closely related to human cancers including genitourinary cancers ( 14 , 15 ). The microbiota of the genitourinary system are the causative factors or cofactors of urinary system tumors such as prostate cancer ( 16 ) and bladder cancer ( 15 ).…”

Section: Introductionmentioning

confidence: 99%

Can Smoking Cause Differences in Urine Microbiome in Male Patients With Bladder Cancer? A Retrospective Study

Zhang

Shen

et al. 2021

Front. Oncol.

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BackgroundTobacco smoking is a carcinogen for many cancers including bladder cancer. The microbiota is involved in the occurrence, development, and treatment of tumors. We explored the composition of male urinary microbiome and the correlation between tobacco smoking and microbiome in this study.MethodsAlpha diversity, principal component analysis (PCA) and Adonis analysis, linear discriminant analysis (LDA) coupled with effect size measurement, and PICRUSt function predictive analysis were used to compare different microbiome between smokers and non-smokers in men.ResultsThere were 26 qualified samples included in the study. Eleven of them are healthy controls, and the others are from men with bladder cancer. Simpson index and the result of PCA analysis between smokers and non-smokers were not different (P > 0.05) in healthy men. However, the abundance of Bacteroidaceae, Erysipelotrichales, Lachnospiraceae, Bacteroides, and so on in the urinary tract of smokers is much higher than that of non-smokers. Compared to non-smokers, the alpha diversity in smokers was elevated in patients with bladder cancer (P < 0.05). PCA analysis showed a significant difference between smokers and non-smokers (P < 0.001), indicating that tobacco smoking plays a vital role in urinary tract microbial composition.ConclusionThe composition of microbiome in the urinary tract is closely related to tobacco smoking. This phenomenon is more significant in patients with bladder cancer. This indicates tobacco smoking may promote the occurrence and development of bladder cancer by changing urinary tract microbiome.

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“…The presence of microbes could be used as a bioindicator to ensure early detection and therefore treatment of disease at its early stages. A method to trace those microbes in response to disease should be devised [ 36 , 37 , 38 , 39 , 40 ]. Microbes need to be characterized in each kind of cancer, and proper control measures need to be devised for treatment [ 40 , 41 , 42 , 43 ].…”

Section: The Microbiome and Its Association With Various Kinds Ofmentioning

confidence: 99%

The Microbiome and Its Implications in Cancer Immunotherapy

Choudhry

2021

Molecules

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Cancer is responsible for ~18 million deaths globally each year, representing a major cause of death. Several types of therapy strategies such as radiotherapy, chemotherapy and more recently immunotherapy, have been implemented in treating various types of cancer. Microbes have recently been found to be both directly and indirectly involved in cancer progression and regulation, and studies have provided novel and clear insights into the microbiome-mediated emergence of cancers. Scientists around the globe are striving hard to identify and characterize these microbes and the underlying mechanisms by which they promote or suppress various kinds of cancer. Microbes may influence immunotherapy by blocking various cell cycle checkpoints and the production of certain metabolites. Hence, there is an urgent need to better understand the role of these microbes in the promotion and suppression of cancer. The identification of microbes may help in the development of future diagnostic tools to cure cancers possibly associated with the microbiome. This review mainly focuses on various microbes and their association with different types of cancer, responses to immunotherapeutic modulation, physiological responses, and prebiotic and postbiotic effects.

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The promise and challenge of cancer microbiome research

Cited by 28 publications

References 216 publications

Skin bacteria of rainbow trout antagonistic to the fish pathogen Flavobacterium psychrophilum

Skin bacteria of rainbow trout antagonistic to the fish pathogen Flavobacterium psychrophilum

Can Smoking Cause Differences in Urine Microbiome in Male Patients With Bladder Cancer? A Retrospective Study

The Microbiome and Its Implications in Cancer Immunotherapy

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