Involuntary Movements and Magnetic Resonance Imaging Findings in Infantile Cobalamine (Vitamin B12) Deficiency

Avcı, Zekai; Turul, Tuba; Aysun, Sabiha; Ünal, Işıil

doi:10.1542/peds.112.3.684

Cited by 41 publications

(37 citation statements)

References 16 publications

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“…[18]. Neurological development in a patient reported by Avci et al [14] was near normal following vitamin B12 treatment, whereas in the 2 presented cases neurological development was normal.…”

Section: Discussionmentioning

confidence: 73%

“…Cerebral atrophy and retarded myelination based on cranial MRI have been reported in many cases of infantile vitamin B12 deficiency [1,4,5,[12][13][14]17]. Cranial MRI in the 2 presented cases showed atrophy in the frontoparietal cortex and interhemispheric region, and dilatation in the ventricles secondary to the observed atrophy.…”

Section: Discussionmentioning

confidence: 88%

“…Their neurologic symptoms improved after initiating clonazepam treatment. Özdemir et al [13] and Avcı et al [14] reported involuntary movements, including tremor and irregular shaking movements, during vitamin B12 treatment. The movements disappeared following clonazepam/piracetam/biperiden hydrochloride therapy.…”

Section: Discussionmentioning

confidence: 99%

“…Avci et al [14] reported a patient with IgG and IgM deficiency that recovered following vitamin B12 treatment. Case 1, who presented due to frequently recurrent infections, had low IgG and IgA levels, and an IgM level at the lower limit of normal, whereas case 2 had low-level IgM.…”

Section: Discussionmentioning

confidence: 99%

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Involuntary movements during vitamin B12 treatment in infants

Tosun¹,

Yz²,

Çeçen³

et al. 2011

Turk J Hematol

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Megaloblastic anemia is rare in infants and is generally due to vitamin B12 (cobalamin) deficiency in the mother. Neurologic symptoms of vitamin B12 deficiency include irritability, failure to thrive, hypotonia, and developmental regression/delay. Herein we present 2 infants with vitamin B12 that developed movement disorder 5 d after initiation of vitamin B12 treatment. Symptoms included tremor and myoclonus, involving in particular the face, tongue, and hands. Clinical findings in infants associated with vitamin B12 deficiency vary, and temporary involuntary movement can be observed during vitamin B12 therapy. (Turk J Hematol 2011; 28: 317-22) Key words: Involuntary movement, vitamin B12 deficiency, infant Received: June 11, 2010 Accepted: October 19, 2010 Özet Süt çocuklarında megaloblastik anemi nadirdir ve genellikle annelerdeki vitamin B12 eksikliğinin bir sonucudur. Kobalamin eksikliğinin nörolojik semptomları huzursuzluk, büyüme geriliği, hipotoni ve nöro-gelişimsel becerilerde gerileme/gecikmeyi içerir. Bu makalede kobalamin tedavisinin 5. gününde özellikle dil, yüz, elleri içine alan tremor ve miyoklonus gibi istemsiz hareketler gelişen, kobalamin eksikliği olan, iki süt çocuğu sunuldu. Süt çocuklarında kobalamin eksikliği farklı klinik bulgularla karşımıza gelebilir ve tedavisi sırasında geçici istemsiz hareketler görülebilir. (Turk J Hematol 2011; 28: 317-22)

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Involuntary movements during vitamin B12 treatment in infants

Tosun¹,

Yz²,

Çeçen³

et al. 2011

Turk J Hematol

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“…6 It has been observed in earlier studies the presence of LRTI, exact reason for this high incidence of LRTI is not known but may be due to presence of less antioxidants due to deficiency of Vitamin C. 7 Infantile tremor syndrome cases always present with various vitamins deficiency and varying degree of anemia. 8 It is most commonly found in children belonging to poor socioeconomic status and who are on exclusive breast feeding of vegetarian mother.…”

Section: Discussionmentioning

confidence: 97%

Infantile tremor syndrome

Puttagunta

Shruthi

Shubha

et al. 2017

Int J Contemp Pediatr

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Infantile tremor syndrome (ITS) is defined by the tetrad of pallor, developmental delay/regression, skin pigmentation, and brown scanty scalp hair. Involuntary movements in the form of tremors supervene in the natural course of the illness in a significant number of cases. The disorder is common in exclusively breast-fed infants of vegetarian mothers. Most of the children eventually recover but are frequently left with long-term cognitive and language neurodeficits. This review attempts to provide comprehensive and up-to-date information on the subject incorporating recently published studies.

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