Invited Review: Long non‐coding <scp>RNA</scp>s: important regulators in the development, function and disorders of the central nervous system

Durán, Raquel; Wei, Haichao; Kim, D. H.; Wu, Jia Qian

doi:10.1111/nan.12541

Cited by 46 publications

(31 citation statements)

References 150 publications

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“…Long non-coding RNAs (lncRNAs) are such variety of RNAs with a length of longer than 200 nucleotides that are not translated into proteins. [9][10][11][12] Their dysfunction and specific role in various diseases, especially cancer, have attracted more and more attention recently. [13][14][15] LncRNAs genomic mutants or alteration have been widely clarified to induce oncogenic effect in multiple cancer types, such as breast cancer, 16 colorectal cancer, 17 ovarian cancer, 18 gastric cancer, 19 lung cancer, 20 as well as AML.…”

Section: Introductionmentioning

confidence: 99%

LncRNA LINC00899 promotes progression of acute myeloid leukaemia by modulating miR‐744‐3p/YY1 signalling

Dong

Guan

2020

Cell Biochemistry & Function

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Long non‐coding RNA (lncRNA) LINC00899 is one kind cytoplasmic lncRNA, however, there is rarely little information about its function in physiological process. Here, we demonstrated that lncRNA LINC00899 was upregulated in acute myeloid leukaemia (AML) cells and was quite correlated with poor prognosis of AML patients. High expression of LINC00899 in AML cells could promote cell proliferation and inhibit cell apoptosis, and facilitate the progression of AML consequently both in vitro and in vivo. Besides, LINC00899 acted as a molecular sponge of miR‐744‐3p. Furthermore, we characterized YY1 as the direct target of miR‐744‐3p, and LINC00899/miR‐744‐3p interaction modulated YY1 expression in AML cells. Finally, we verified LINC00899 modulated AML cell proliferation and apoptosis via regulating YY1. Our study revealed novel mechanism about how did lncRNA LINC00899 execute function in AML and thus provided potential therapeutic interventions for AML.Significance of the study LncRNA LINC00899 is upregulated in AML cells and is correlated with poor prognosis of AML patients. LncRNA LINC00899 mediates cell proliferation and apoptosis of acute myeloid leukaemia cells. Knockdown of LINC00899 inhibited the growth of xenograft glioma tumour in vivo. LINC00899 acts as a molecular sponge of miR‐744‐3p. YY1 is the downstream target of LINC00899/miR‐744‐3p signalling.

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Section: Introductionmentioning

confidence: 99%

LncRNA LINC00899 promotes progression of acute myeloid leukaemia by modulating miR‐744‐3p/YY1 signalling

Dong

Guan

2020

Cell Biochemistry & Function

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“…For example, RNA antisense purification (RAP), chromatin isolation by RNA purification-sequencing (ChIRP), and capture hybridization analysis of RNA targets (CHART) are popular methods to identify target genes of lncRNAs. RNA pull-down assays, RNA immunoprecipitation followed by high-throughput sequencing (RIP-seq), and RAP-mass spectrometry (RAP-MS) are also commonly used to explore the interactions between lncRNAs and proteins [96]. In addition, the recent single-cell RNA-Seq technique provides a new opportunity for explaining the roles of lncRNAs at the single-cell resolution to understand their cell-specific mechanisms.…”

Section: Lncrnas In Scimentioning

confidence: 99%

The Emerging Role of lncRNAs in Spinal Cord Injury

Wang

Liu

Wang

et al. 2019

BioMed Research International

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Spinal cord injury (SCI) is a highly debilitating disease and is increasingly being recognized as an important global health priority. However, the mechanisms underlying SCI have not yet been fully elucidated, and effective therapies for SCI are lacking. Long noncoding RNAs (lncRNAs), which form a major class of noncoding RNAs, have emerged as novel targets for regulating several physiological functions and mediating numerous neurological diseases. Notably, gene expression profile analyses have demonstrated aberrant changes in lncRNA expression in rats or mice after traumatic or nontraumatic SCI. LncRNAs have been shown to be associated with multiple pathophysiological processes following SCI including inflammation, neural apoptosis, and oxidative stress. They also play a crucial role in the complications associated with SCI, such as neuropathic pain. At the same time, some lncRNAs have been found to be therapeutic targets for neural stem cell transplantation and hydrogen sulfide treatment aimed at alleviating SCI. Therefore, lncRNAs could be promising biomarkers for the diagnosis, treatment, and prognosis of SCI. However, further researches are required to clarify the therapeutic effects of lncRNAs on SCI and the mechanisms underlying these effects. In this study, we reviewed the current progress of the studies on the involvement of lncRNAs in SCI, with the aim of drawing attention towards their roles in this debilitating condition.

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“…While the precise expression levels of ncRNAs are key for the normal function of the CNS, the deregulation of ncRNA pathways have been linked to human disease, including neurodegenerative conditions [8][9][10][11]. In the present manuscript, we will provide an overview on the functional association between ncRNAs and the response to OS, a major hallmark in neurodegenerative disorders, and we will review the OS-ncRNA axis in major neurodegenerative conditions.…”

Section: Introductionmentioning

confidence: 99%

Non-Coding RNAs as Sensors of Oxidative Stress in Neurodegenerative Diseases

et al. 2020

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Oxidative stress (OS) results from an imbalance between the production of reactive oxygen species and the cellular antioxidant capacity. OS plays a central role in neurodegenerative diseases, where the progressive accumulation of reactive oxygen species induces mitochondrial dysfunction, protein aggregation and inflammation. Regulatory non-protein-coding RNAs (ncRNAs) are essential transcriptional and post-transcriptional gene expression controllers, showing a highly regulated expression in space (cell types), time (developmental and ageing processes) and response to specific stimuli. These dynamic changes shape signaling pathways that are critical for the developmental processes of the nervous system and brain cell homeostasis. Diverse classes of ncRNAs have been involved in the cell response to OS and have been targeted in therapeutic designs. The perturbed expression of ncRNAs has been shown in human neurodegenerative diseases, with these changes contributing to pathogenic mechanisms, including OS and associated toxicity. In the present review, we summarize existing literature linking OS, neurodegeneration and ncRNA function. We provide evidences for the central role of OS in age-related neurodegenerative conditions, recapitulating the main types of regulatory ncRNAs with roles in the normal function of the nervous system and summarizing up-to-date information on ncRNA deregulation with a direct impact on OS associated with major neurodegenerative conditions.

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Invited Review: Long non‐coding RNAs: important regulators in the development, function and disorders of the central nervous system

Cited by 46 publications

References 150 publications

LncRNA LINC00899 promotes progression of acute myeloid leukaemia by modulating miR‐744‐3p/YY1 signalling

LncRNA LINC00899 promotes progression of acute myeloid leukaemia by modulating miR‐744‐3p/YY1 signalling

The Emerging Role of lncRNAs in Spinal Cord Injury

Non-Coding RNAs as Sensors of Oxidative Stress in Neurodegenerative Diseases

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