‘Invisible’ orthodontics by polymeric ‘clear’ aligners molded on 3D-printed personalized dental models

Abstract

The malalignment of teeth is treated classically by metal braces with alloy wires, which has an unfavorable influence on the patients’ appearance during the treatment. Herein, a modern treatment was tried using clear polymeric aligners, which were fabricated by molding a film material on the three dimensional (3D) printed personalized dental models. The key parameters of photocurable 3D printing of dental models and the mechanical properties of the clear aligner film material were investigated. Following a series of 3D-printed personalized dental models and finite element analysis to predict and plan the fabrication and orthodontic processes, clear aligners were fabricated and applied in animal experiments to prove the efficacy and biocompatibility. A clinical treatment was finally carried out, which highlights the advantage of the clear aligners as an esthetic, compatible and efficient appliance.

3D-Printed Porous Scaffolds of Hydrogels Modified with TGF-β1 Binding Peptides to Promote In Vivo Cartilage Regeneration and Animal Gait Restoration

“…They found that the actual pore system in the polyisocyanate-based hydrogel was up to 3.7 μm, which may be insufficient for cell migration. However, the pore size of a scaffold can be well controlled and the global shape of a scaffold can be individually designed via 3D printing. ,, …”

A coordination strategy to achieve instant dissolution of a biomedical polymer in water via manual shaking

“…These additional treatments to accelerate polymer dissolution work well in labs, yet are unsuitable in many situations such as in hospitals where there is an instant demand. While much progress has been made in the fields of polymers and biomaterials, 45–52 the instant dissolution of a biomedical polymer in water has rarely been achieved. So far, no theory has been provided for the rapid dissolution of polymers without using additional treatments.…”

Cytarabine delivered by CD44 and bone targeting redox-sensitive liposomes for treatment of acute myelogenous leukemia

“…The absorbance value was measured at 570 nm using an Elx800 microplate reader. Cells without liposomes or free cytarabine treatment were used as a negative control, cell viability was calculated as (OD test group/OD control group) × 100% [ 23 , 24 ].…”