A coordination strategy to achieve instant dissolution of a biomedical polymer in water <i>via</i> manual shaking

Tang, Jingyu; Cai, Caiyun; Cao, Dinglingge; Rao, Weihan; Guo, Wen; Yu, Lin; Ding, Jiandong

doi:10.1039/d2bm00814a

Cited by 3 publications

(1 citation statement)

References 64 publications

(83 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the clinical translation of this raw material in the future will be much valuable. Very recently, Ding’s group realize the dissolution of PLGA-PEG-PLGA block copolymers within half minute via manual shaking using a calcium coordination strategy [ 153 ]. While some additives could influence the performances of PLGA-PEG-PLGA-based hydrogels [ 154 ], appropriate small molecular soluble additives could accelerate the dissolution of chain-like polymers and meanwhile maintain the thermogellability.…”

Section: The Different Sources Of Biomaterials For Tissue Regenerationmentioning

confidence: 99%

Recent advances in regenerative biomaterials

Cao

Ding

2022

Regenerative Biomaterials

Self Cite

View full text Add to dashboard Cite

Nowadays, biomaterials have evolved from the inert supports or functional substitutes, to the bioactive materials able to trigger or promote the regenerative potential of tissues. The interdisciplinary progress has broadened the definition of “biomaterials”, and a typical new insight is the concept of tissue induction biomaterials. The term “regenerative biomaterials” and thus the contents of the present paper are relevant to yet beyond tissue induction biomaterials. This review summarizes the recent progress of medical materials including metals, ceramics, hydrogels, other polymers, and bio-derived materials. As the application aspects are concerned, this paper introduces regenerative biomaterials for bone and cartilage regeneration, cardiovascular repair, three dimensional bioprinting, wound healing, and medical cosmetology. Cell-biomaterial interactions are highlighted. Since the global pandemic of COVID-19, the review particularly mentions biomaterials for public health emergency. In the last section, perspectives are suggested: (1) Creation of new materials is the source of innovation; (2) Modification of existing materials is an effective strategy for performance improvement; (3) Biomaterial degradation and tissue regeneration are required to be harmonious with each other; (4) Host responses can significantly influence the clinical outcomes; (5) The long-term outcomes should be paid more attention to; (6) The non-invasive approaches for monitoring in vivo dynamic evolution are required to be developed; (7) Public health emergencies call for more research & development of biomaterials; (8) Clinical translation needs to be pushed forward in a full-chain way. In the future, more new insights are expected to be shed into the brilliant field — regenerative biomaterials.

show abstract

Section: The Different Sources Of Biomaterials For Tissue Regenerationmentioning

confidence: 99%

Recent advances in regenerative biomaterials

Cao

Ding

2022

Regenerative Biomaterials

Self Cite

View full text Add to dashboard Cite

show abstract

Research on triamcinolone-loaded thermosensitive chitosan hydrogels for preventing esophageal stricture induced by endoscopic submucosal dissection

Wang,

Su,

Zhu

et al. 2024

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

Efficacy and safety of a submucosal injection solution of sodium alginate for endoscopic resection in a porcine model

Jung,

Lee,

Jang

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Endoscopic resection techniques require the use of submucosal injection. Normal saline and sodium hyaluronate solutions are mainly used for this purpose, but an ideal solution has not yet been developed. The aim of this study was to assess a new solution, MC-003—a novel submucosal injection solution developed with sodium alginate as the main ingredient. Normal saline, a commercial sodium hyaluronate solution (Endo-Ease), and MC-003 were examined. A total of 18 gastric submucosal cushions were created in the stomachs of six pigs. The height of mucosal elevation was measured sequentially using endoscopic sonography. After euthanizing the animals either 2 h or 5 days after the procedure, pathologic examination was performed for each injection site. Although not statistically significant over the entire study period, MC-003 showed a superior result to normal saline and an equivalent result to Endo-Ease in the submucosal cushion height and its rate of decrease. There were no adverse outcomes after injection of the three solutions and there was no pathologically identified detrimental change in the resected specimens. MC-003 creates a sufficient submucosal fluid cushion without apparent tissue damage. It can be considered as an effective submucosal injection material.

show abstract

A coordination strategy to achieve instant dissolution of a biomedical polymer in water via manual shaking

Abstract: Organic polymers with condensed long chains are kinetically slow to be dissolved in their solvents, particularly in water, which has significantly hindered their potential applications as soon as an instant...

Cited by 3 publications

References 64 publications

Recent advances in regenerative biomaterials

Recent advances in regenerative biomaterials

Research on triamcinolone-loaded thermosensitive chitosan hydrogels for preventing esophageal stricture induced by endoscopic submucosal dissection

Efficacy and safety of a submucosal injection solution of sodium alginate for endoscopic resection in a porcine model

Contact Info

Product

Resources

About