Invigorating chronic wound healing by nanocomposites composed with bioactive materials: a comprehensive review

Manjubaashini, N.; Gosala, Radha; Balakumar, S.

doi:10.1007/s10529-022-03303-5

Cited by 5 publications

(1 citation statement)

References 73 publications

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“…However, bacterial and inflammatory factors around chronic wounds do not offer adequate stability to support ECM exchange ( Liu et al, 2023a ). Wound healing is an important part of the biomedical field, but its development remains in its early stages ( Nandhakumar et al, 2022 ). With the development of biomedicine, gelatin has been used in anti-tumor, tissue repair, regenerative medicine, and many other fields because of its biocompatibility and degradability ( Xia et al, 2022a ; Xia et al, 2022b ; Xia et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Gelatin-based biomaterials and gelatin as an additive for chronic wound repair

Cao,

Wang,

Hao

et al. 2024

Front. Pharmacol.

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Disturbing or disrupting the regular healing process of a skin wound may result in its progression to a chronic state. Chronic wounds often lead to increased infection because of their long healing time, malnutrition, and insufficient oxygen flow, subsequently affecting wound progression. Gelatin—the main structure of natural collagen—is widely used in biomedical fields because of its low cost, wide availability, biocompatibility, and degradability. However, gelatin may exhibit diverse tailored physical properties and poor antibacterial activity. Research on gelatin-based biomaterials has identified the challenges of improving gelatin’s poor antibacterial properties and low mechanical properties. In chronic wounds, gelatin-based biomaterials can promote wound hemostasis, enhance peri-wound antibacterial and anti-inflammatory properties, and promote vascular and epithelial cell regeneration. In this article, we first introduce the natural process of wound healing. Second, we present the role of gelatin-based biomaterials and gelatin as an additive in wound healing. Finally, we present the future implications of gelatin-based biomaterials.

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