Chitosan bioactive glass scaffolds for in vivo subcutaneous implantation, toxicity assessment, and diabetic wound healing upon animal model

Manjubaashini, N.; Bargavi, P.; Thomas, Nebu George; Krishnan, Nikhil; Balakumar, S.

doi:10.1016/j.ijbiomac.2023.128291

Cited by 3 publications

(2 citation statements)

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“…Nanobioactive glass (BG) is commonly considered as an appropriate material for BTE applications. By encouraging the formation of new tissue and releasing ions into the physiological environment, they can aid in the mending of bone tissue. , These outcomes significantly increase osteoblastic activity, which aids in the process of overall regeneration …”

Section: Introductionmentioning

confidence: 99%

“…By encouraging the formation of new tissue and releasing ions into the physiological environment, they can aid in the mending of bone tissue. 8,9 These outcomes significantly increase osteoblastic activity, which aids in the process of overall regeneration. 10 We created a new physiologically active bilayer scaffold in our work, with gelatin and alginate serving as the main raw components.…”

Section: Introductionmentioning

confidence: 99%

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Productizing Nano-Bioactive Glass-Based Bilayer Scaffolds: A Graft for Reconstruction of Mandibular and Femoral Bone Defects

Krishnamoorthy,

Purusothaman,

Subramanian

2024

ACS Appl. Mater. Interfaces

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This investigation aimed to construct a bilayer scaffold integrating alginate and gelatin with nanobioactive glass (BG), recognized for their efficacy in tissue regeneration and drug delivery. Scaffolds, namely, alginate/gelatin (AG), alginate-/actonel gelatin (AGD), alginate actenol/gelatin-45S5 BG (4AGD), and alginate-actonel/gelatin-59S BG (5AGD), were assembled using a cost-effective freeze-drying method, followed by detailed structural investigation via powder X-ray diffraction as well as morphological characterization using field emission scanning electron microscopy (FESEM). FESEM revealed a honeycomb-like morphology with distinct pore sizes for nutrient, oxygen, and drug transport. The scaffolds evidently exhibited hemocompatibility, high porosity, good swelling capacity, and biodegradability. In vitro studies demonstrated sustained drug release, particularly for scaffolds containing actonel. In vivo tests showed that the bilayer scaffold promoted new bone formation, surpassing the control group in bone area increase. The interaction of the scaffold with collagen and released ions improved the osteoblastic function and bone volume fraction. The findings suggest that this bilayer scaffold could be beneficial for treating critical-sized bone defects, especially in the mandibular and femoral regions.

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Section: Introductionmentioning

confidence: 99%