As the two largest economies in the world, the investor sentiment and stock return of China and the United States are the focus of global attention. In this paper, we study the dynamic spillover effects of investor sentiment and return between China and the United States. First, we use the relative price differences of 9 dual-listed companies in China and the United States simultaneously to verify whether investor sentiment affects stock returns. We find a significant positive correlation between the relative price difference of dual-listed companies and the difference of investor sentiment, indicating that the investor sentiment index indeed affects stock prices. Next, we construct the TVP-VAR model to study the dynamic spillover effects of investor sentiment and the return between China and the United States. Through the time-varying impulse response, we find investor sentiment has a significant dynamic impact on returns. Therefore, investment sentiment contagion and stock market linkage between China and the United States are obvious. In addition, we conduct various robust tests, and all results are consistent.