Investigations on the renin-angiotensin system in acute severe asthma

Ramsay, S. G.; Dagg, Kenneth D; McKay, I C; Lipworth, BJ; McSharry, Charles; Thomson, Neil C.

doi:10.1183/09031936.97.10122766

Cited by 38 publications

(20 citation statements)

References 38 publications

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“…In our study, the serum levels of AGT and ACE were higher, although not significantly, in the chronic severe asthma group where β-agonist therapy was withheld compared with those of the control group. According to literature, this elevation can be affected by pharmacological agents such as β-agonists or the pathophysiological features of asthma (17,22,23). Because of the limitations of our study, we could not evaluate the exact reason for the elevated serum levels of AGT and ACE in the asthma group.…”

Section: Discussionmentioning

confidence: 79%

Evaluation of Serum Levels of Renin Angiotensin System Components in Asthmatic Patients

Ayada¹,

Toru²,

Genç³

et al. 2015

Erciyes Med J

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Objective: Asthma is a chronic inflammatory lung disease. The renin-angiotensin system (RAS) targets several tissues and maintains fluid homeostasis. It is also known that RAS plays a role in inflammatory processes. Angiotensin-converting enzyme (ACE) and its product angiotensin II (AngII), which are the components of RAS, regulate the known effects of RAS. The other components of RAS, ACE2 and its product Ang 1-7, regulate the counter-effects of RAS. That is why the activation or inhibition of RAS can offer new therapeutic strategies for treating several diseases. We aimed to investigate the serum level of RAS components such as angiotensinogen (AGT), ACE, AngII, ACE2, and Ang 1-7 in asthma and control groups. Materials and Methods:This study was performed on 27 asthma and 23 healthy individuals. The serum levels of AGT, ACE, AngII, ACE2, and Ang 1-7 were measured by human enzyme-linked immunosorbent assay (ELISA) kits.Results: There were no statistically significant differences for the serum levels of AGT and ACE between the groups. The serum levels of AngII, ACE2, and Ang 1-7 were significanlty higher in the asthma group than those in the control group. Conclusion:Our results indicate that two tails of RAS, i.e., the ACE and ACE2 pathways, are activated in asthma compared to are activated more in the asthma group than in the control group. We suppose that the activation of ACE2 tail of RAS occurs because of the homeostatic balance requirements of this system. We believe that the activation of ACE2 pathway, in addition to the inhibition of the ACE pathway, can provide clinical benefits in treating asthma.

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Section: Discussionmentioning

confidence: 79%

Evaluation of Serum Levels of Renin Angiotensin System Components in Asthmatic Patients

Ayada¹,

Toru²,

Genç³

et al. 2015

Erciyes Med J

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“…Hypomagnesemia may also increase the neuromuscular irritability, thus making a few individuals more susceptible to the bronchial spasms. Low dietary magnesium was also found to be associated with wheezes and impairment of lung function in normal subjects, while magnesium supplementation can reduce asthma symptoms [14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Assessment of serum magnesium level in patients with bronchial asthma

Ali

Bakr

Yousif

et al. 2015

Egyptian Journal of Chest Diseases and Tuberculosis

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Background: Asthma is one of the most common chronic diseases worldwide and has been increasing in prevalence over the last few decades. Magnesium ion has an inhibitory action on smooth muscle contraction, histamine release from mast cells and acetylcholine release from cholinergic nerve terminals. Magnesium has been shown to relax bronchial smooth muscles and influence the function of respiratory muscles. Hypomagnesemia have been associated with diminished respiratory muscle power.Aim: To assess the serum Mg levels in bronchial asthma patients during stable and exacerbating clinical conditions. Subjects and methods: 60 Subjects were enrolled, 40 patients diagnosed as bronchial asthma and 20 healthy individuals as a control group. The asthmatic patients were divided into group (I) chronic stable bronchial asthma and group (II) acute exacerbation of bronchial asthma.Results: Serum Mg levels were significantly lower in asthmatic patients compared with healthy controls and significantly lower in asthmatic patients during exacerbation compared with stable asthmatics. There was a positive correlation between serum Mg levels and each of FEV1/FVC ratio and FEV1.Conclusion: Hypomagnesemia was found in patients with chronic stable asthma and also in those with acute asthma exacerbation compared to control. Serum mg levels were significantly lower in asthmatic patients during exacerbations compared with stable asthmatics.

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“…The mechanism of this activation is unclear, but recent evidence has shown elevation of renin and angiotensin II in response to nebulized and intravenous salbutamol. 12,13 It can be seen that this phenomenon may be confined to only hymenoptera venom sensitive patients. However, further studies should be planned to fully define the responsiveness of the RAAS in sensitized subjects.…”

Section: Resultsmentioning

confidence: 99%

Renin angiotensin aldosterone system in anaphylactic reactions induced by immunotherapy

Karaayvaz

Ozangüç

1998

Allergology International

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Although patients with a history of hymenoptera venom anaphylaxis showed significantly reduced plasma levels of angiotensin-I and angiotensin-II compared to controls, there is no study in the literature to investigate the renin angiotensin aldosterone system (RAAS) in patients with anaphylactic reaction induced by immunotherapy. The purpose of this study is to determine the role of the renin angiotensin aldosterone system in patients who had an anaphylactic reaction induced by allergen immunotherapy with pollen, house-dust and mold extracts. Plasma levels of angiotensin-I, angiotensin-II, angiotensin converting enzyme and aldosterone were measured in 20 patients who experienced anaphylaxis during allergen immunotherapy. The control group consisted of 15 immunotherapy patients without any history of anaphylaxis. The Mann-Whitney U-test was performed for comparison of the two groups, and a P value less than 0.05 was considered statistically significant. Angiotensin-I, angiotensin-II, angiotensin converting enzyme and aldosterone levels were similar in both the study and control groups and no statistical significance was found between the two groups (P > 0.05). The RAAS does not appear to play a role in the pathogenesis of anaphylactic reactions due to allergen immunotherapy with pollen, housedust and mold extracts.

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Investigations on the renin-angiotensin system in acute severe asthma

Cited by 38 publications

References 38 publications

Evaluation of Serum Levels of Renin Angiotensin System Components in Asthmatic Patients

Evaluation of Serum Levels of Renin Angiotensin System Components in Asthmatic Patients

Assessment of serum magnesium level in patients with bronchial asthma

Renin angiotensin aldosterone system in anaphylactic reactions induced by immunotherapy

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