Assessment of serum magnesium level in patients with bronchial asthma

Ali, Atif; Bakr, Ramadan; Yousif, Maha; Foad, Rania E.

doi:10.1016/j.ejcdt.2015.04.010

Cited by 13 publications

(16 citation statements)

References 15 publications

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“…Hypomagnesemia has been defined by a serum magnesium level <1.8 mg/dl in males and <1.9 mg/dl in females [13, 14] (reference ranges of magnesium in the study laboratory were 1.8–2.6 mg/dl in males and 1.9–2.5 mg/dl in females); obesity has been defined as a BMI ≥30 kg/m 2 , while insulin resistance has been defined as a HOMA-IR index ≥3 [15-17]; diabetes has been defined as a fasting plasma glucose level ≥126 mg/dL, which can be confirmed by repeated testing, previous diagnosis of diabetes, or the current use of antidiabetic medications; lastly, pre-DM has been defined as the presence of a fasting plasma glucose level ≥100 but <126 mg/dl [18]. The identification of metabolic syndrome (MS) conformed to the definition used by the National Cholesterol Education Program Adult Treatment Panel III guidelines [19].…”

Section: Methodsmentioning

confidence: 99%

Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study

Toprak

Kurt

Sarı

et al. 2017

Kidney Blood Press Res

20,441

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Background/Aims: Magnesium is an essential mineral for many metabolic functions. There is very little information on the effect of magnesium supplementation on metabolic profiles of chronic kidney disease (CKD) patients. The aim of this study was to assess the influence of magnesium supplementation on metabolic profiles of pre-diabetic, obese and mild-to-moderate CKD patients with hypomagnesemia. Methods: A total of 128 hypomagnesemic, pre-diabetic and obese patients with an estimated glomerular filtration rate between 90 and 30 ml/min/1.73m² were enrolled in a randomised, double-blind, placebo-controlled trial. Patients in the magnesium group received 365 mg of oral magnesium (n = 57) once daily for 3 months, while patients in the control group received a placebo (n = 61), also once daily for 3 months. Hypomagnesemia is defined by a serum magnesium level <1.8 mg/dl in males and <1.9 mg/dl in females; obesity is defined as a body mass index ≥30 kg/m²; and pre-diabetes is defined as fasting plasma glucose ≥100 but <126 mg/dl. The primary end point of the study was the change in insulin resistance measured by the homeostastic model assessment for insulin resistance (HOMA-IR). Results: At the end of follow-up, insulin resistance (-24.5 vs. -8.2%, P = 0.007), HOMA-IR index (-31.9 vs. -3.3%, P < 0.001), hemoglobin A1c (-6.6 vs. -0.16%, P < 0.001), insulin (-29.6 vs. -2.66%, P < 0.001), waist circumference (-4.8 vs. 0.55%, P < 0.001) and uric acid (-0.8 vs. 2.2%, P = 0.004) were significantly decreased in terms of mean changes; albumin (0.91 vs. -2.91%, P = 0.007) and magnesium (0.21 ± 0.18 vs. -0.04 ± 0.05 mg/dl, P < 0.001) were significantly increased in those taking magnesium compared with a placebo. The decrease in metabolic syndrome (-10.5 vs. -4.9%, P = 0.183), obesity (-15.7 vs. -8.2%, P = 0.131), pre-diabetes (-17.5 vs. -9.8%, P = 0.140), and systolic (-5.0 ± 14.8 vs. 0.22 ± 14.9 mm Hg, P = 0.053) and diastolic (-3.07 ± 9.7 vs. 0.07 ± 9.6 mm Hg, P = 0.071) blood pressure did not achieve to a significant level after study. Conclusion: Our data support the argument that magnesium supplementation improves the metabolic status in hypomagnesemic CKD patients with pre-diabetes and obesity.

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Section: Methodsmentioning

confidence: 99%

Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study

Toprak

Kurt

Sarı

et al. 2017

Kidney Blood Press Res

20,441

View full text Add to dashboard Cite

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“…As per few earlier reports, magnesium (Mg) deficiency is associated with increased tracheobronchial hyperreactivity, pulmonary vascular drag, and ventricular arrhythmia [7, 8]. Treatment with β 2 -agonists can reduce magnesium levels in serum by intracellular shift or urinary loss [8].…”

Section: Introductionmentioning

confidence: 99%

“…Magnesium (Mg) as the second most plentiful intracellular cation and an important part of bone mineralization has a crucial function in synthesis and metabolism of vitamin D. Lower levels of serum magnesium are associated with hypovitaminosis D [10, 11]. Hypomagnesemia lowers the concentration of vitamin D in body which can worsen the clinical condition in asthma by tracheobronchial hyperreactivity and by increasing susceptibility to respiratory infections [4, 5, 7, 9, 10]. …”

Section: Introductionmentioning

confidence: 99%

Serum Magnesium and Vitamin D Levels as Indicators of Asthma Severity

et al. 2016

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Background. Serum magnesium levels affect the concentration of circulating vitamin D in blood and subsequently it affects the immunity; thus it plays significant role in the pathogenesis of asthma. Asthma, in adults, is less studied and hypomagnesemia along with vitamin D deficiency and insufficiency is common in asthmatic individuals, which causes frequent asthma attacks, respiratory infections, severe exacerbations, and poor response to bronchodilators. Objective. To detect the magnitude of vitamin D insufficiency and deficiency and serum magnesium levels among asthmatic patients and to correlate them with the severity of asthma. Materials and Methods. This is a cross-sectional case-control study which includes 60 patients of chronic stable asthma and 60 healthy controls. After taking clinical history and systemic examination, pulmonary function test was done. Serum levels of magnesium, 25-hydroxycholecalciferol [25(OH)D], and calcium were measured in all the subjects. Results. Significant correlation was found between vitamin D deficiency, hypomagnesemia, and asthma severity. Serum calcium levels were unaffected by that. Conclusion. Vitamin D and serum magnesium deficiency are highly prevalent in patients with asthma. Increased asthma severity, frequency of attacks, and exacerbation are associated with lower levels of one or both. Serum 25(OH)D and magnesium levels may serve as important markers of asthma severity.

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“…The result of this study agreed with the observation of previous studies. [31][32] Low serum level of Mg 2+ in asthmatic children may be related to either low Mg 2+ intake or increase urinary loss of Mg 2+ as a side effect of other therapy used for the treatment of asthma such as β 2 agonist, corticosteroid and theophylline. 33 Magnesium ion has an inhibitory action on smooth muscle contraction, histamine release from mast cells and acetylcholine release from cholinergic nerve terminals.…”

Section: Discussionmentioning

confidence: 99%

“…As such hypomagnesaemia have been associated with diminished respiratory muscles power which can aggravate the severity of asthma. 32 Magnesium ion also play a role in the activation of vitamin D in the kidney, as such diminished level of this ion can lead to a decrease production of vitamin D which can also increase the severity of asthma. 34 The finding of high prevalence of vitamin D deficiency obser ved among the asthmatic children was in agreement with the previous studies of.…”

Section: Discussionmentioning

confidence: 99%

Serum vitamin D status and biochemical parameters of asthmatic children in Sokoto Metropolis, North-western Nigeria

Yeldu¹,

Danjuma²,

Sulaiman³

et al. 2019

Asian J Med Sci

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Background: Asthma is a common chronic disorder of the airways that is complex and characterized by variable and recurring symptoms. It is characterized by the occurrence of bronchial hyper responsiveness, airflow obstruction and an underlying inflammation. Several studies have proposed the association of vitamin D with increased incidence of asthma symptoms. Aims and Objectives: This study aimed at determining the serum vitamin D status and biochemical parameters among asthmatic children in Sokoto-Nigeria. Materials and Methods: The study population consisted of 120 subjects including 80 asthmatic children and 40 age-and sex-matched apparently healthy controls from two tertiary Hospitals in Sokoto Metropolis. Serum vitamin D, calcium, parathyroid hormone (PTH), immunoglobulin E (IgE) and magnesium were measured using standard techniques. Results: Mean serum vitamin D and magnesium were significantly (p ˂ 0.05) lower, while serum PTH and IgE were significantly higher (p˂0.001) in asthmatic children than in controls. Vitamin D insufficiency was found to be prevalent among the asthmatic children. There was no significant relationship between the low level of vitamin D and asthma severity. Conclusion: This study observed that, hypovitaminosis D and hypomagnesaemia occurred among asthmatic children, and asthma was more prone in the younger children than in their older counterpart. It is recommended that in order to avoid or limit the rate of children having asthmatic episodes, vitamin D and magnesium supplements should be used in the management of asthmatic children.

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Assessment of serum magnesium level in patients with bronchial asthma

Cited by 13 publications

References 15 publications

Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study

Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study

Serum Magnesium and Vitamin D Levels as Indicators of Asthma Severity

Serum vitamin D status and biochemical parameters of asthmatic children in Sokoto Metropolis, North-western Nigeria

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