Background. Serum magnesium levels affect the concentration of circulating vitamin D in blood and subsequently it affects the immunity; thus it plays significant role in the pathogenesis of asthma. Asthma, in adults, is less studied and hypomagnesemia along with vitamin D deficiency and insufficiency is common in asthmatic individuals, which causes frequent asthma attacks, respiratory infections, severe exacerbations, and poor response to bronchodilators. Objective. To detect the magnitude of vitamin D insufficiency and deficiency and serum magnesium levels among asthmatic patients and to correlate them with the severity of asthma. Materials and Methods. This is a cross-sectional case-control study which includes 60 patients of chronic stable asthma and 60 healthy controls. After taking clinical history and systemic examination, pulmonary function test was done. Serum levels of magnesium, 25-hydroxycholecalciferol [25(OH)D], and calcium were measured in all the subjects. Results. Significant correlation was found between vitamin D deficiency, hypomagnesemia, and asthma severity. Serum calcium levels were unaffected by that. Conclusion. Vitamin D and serum magnesium deficiency are highly prevalent in patients with asthma. Increased asthma severity, frequency of attacks, and exacerbation are associated with lower levels of one or both. Serum 25(OH)D and magnesium levels may serve as important markers of asthma severity.

Background & Methods: In our study we have 50 patients, matured 10-65 years, with asthma in moderate or serious stages, and whereas 25 healthy controls. Asthma is a multifactorial infection and its seriousness fluctuates with the incendiary evaluation. The subjects of serum concentration of Zn, Cu, and Mg were estimated by means of semiautoanalyser after data findings & clinical assessments at Saraswati Medical College, Unnao, U.P. Results: 25 Healthy cases 44% are Males whereas 56% are Females, & in patient category 48% were males & 52% were females. The Mean levels of Serum Mean & SD of Magnesium concentration of patients was 131.5 ± 24.7 µg/L where as Healthy were 131.3 ± 19.3 µg/L. Mean & SD of Copper concentration of patients was 1021.9 ± 188 µg/L same Mean value with healthy were 1021.9 ± 188 µg/L. Mean & SD of Zinc concentration of patients was 1013 ± 178 µg/L where as Healthy were 957 ± 284 µg/L. Zn & Mg in patients among allergic asthma were lesser as compared than in the healthy control group Conclusions:In our study we found the Low levels of trace elements, mainly Zn, may have a important role to play in the pathogenesis of allergic asthma, meanwhile the substitution of these elements may be a useful asthma patients treatment.