Investigations on the Nature of Hemophilia A

Mammen, Eberhard F.

doi:10.1055/s-0038-1654959

Cited by 11 publications

(14 citation statements)

References 13 publications

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“…nudum, and suggested that they might represent a juvenile colony of another species. Mammen (1963) referred specimens from south India to /?. nudum, but noted that they possibly belonged to another species.…”

Section: Rkmarksmentioning

confidence: 99%

“…(Vervoort, 1959), but Millard (1975) cautioned that most records provide insufficient information to verify identification. Although the species has been frequently recorded from warm waters (e.g., Fraser, , 1948Mammen, 1963;Millard and Bouillon, 1974;Cooke, 1975;Millard, 1975), hydroids from Bermuda were nevertheless referred to E. capillare with some reservation given the northerly type locality of this species. Unfortunately, type material of E. capillare could not be located (Cornelius and Garfath, 1980), but specimens from Bermuda corresponded with Alder's (1856a) figures and brief description of the species.…”

Section: Remarksmentioning

confidence: 99%

“…He recognized Halocordyle Allman, 1872, as the valid name of the genus, and established the name Halocordylidae for the family. This family name has now gained widespread use (e.g., Rees, 1957;Pennycuik, 1959;Vervoort, 1959;Mammen, 1963;Calder, 1971;Cooke, 1975;Millard, 1975;Hirohito, 1977;Petersen, 1979;Bouillon, 1985;Garcia-Corrales and Aguirre, 1985). The family names Pennariidae and Halocordylidae cannot be regarded as synonyms because the nominal genera Pennaria and Halocordyle are not even in the same order.…”

Section: Diagnosismentioning

confidence: 99%

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Shallow-Water Hydroids of Bermuda. The Athecatae

Díaz¹,

Calder²

1991

Estuaries

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sidered according to provisions of the International Code of Zoological Nomenclature (International Commission on Zoological Nomenclature [iczn|, 1985). Some of the nomenclatural problems encountered have been resolved here, while others will require submissions to the commission. Questions regarding the identity, synonymy, and systematic positions of taxa arose repeatedly during the course of this study. One quandary in particular involved the extent to which nominal species should be combined or divided. The hydrozoan literature is replete with extremes of taxonomic "lumping" and "splitting," and the confusion resulting from both. For example, Duchassaing and Michelotti (1864) viewed practically every morphological form of the hydrocoral Millepora Linnaeus, 1758, from the Caribbean as a distinct species, whereas Hickson (1898a, 1898b) recognized only one species in the genus worldwide. Most authors now follow Boschma (1948) in recognizing three species in the Caribbean, and about a dozen worldwide. Nevertheless, determining how far to go in combining or splitting nominal species is largely a matter of personal opinion. Most recent hydrozoan systematists have tended to be "taxonomic lumpers," and generally broad taxa have been recognized here. Reasons why relatively few species of hydroids are believed to exist worldwide were briefly stated by Cornelius (1981). Related to the question of lumping or splitting of taxa is the interpretation of hydroid species distribution. According to literature records, many species of hydroids are virtually cosmopolitan. Admittedly, certain hydroids are well adapted for long-range dispersal, and their rate of speciation seems to be rather slow (Cornelius, 1981). Yet the question arises whether some species are as widely distributed as records indicate, or whether their reported range is partly an artifact of the hydrozoan taxonomist's inability to discriminate distinct but closely related species. Hydrozoan classification is complicated by many factors, including the following: (1) the existence of separate hydroid and medusa generations in many species; (2) the legacy of separate classifications for hydroids and medusae; (3) the production of free medusae and fixed gonophores in closely related species; (4) the differential reduction of male and female gonophores in certain species; (5) the production in some taxa of morphologically dissimilar medusae by virtually indistinguishable hydroids, and vice versa; (6) the morphological variation sometimes displayed within a given taxon; (7) the scarcity of reliable taxonomic characters in various taxa; (8) the general lack of knowledge concerning the biology of these animals, including life cycles of many species. Classification of the order Athecatae Hincks, 1868, in particular is currently in a state of flux. Most authors over the past 30 years have regarded the Capitata Kiihn, 1913, as the most primitive suborder of the Hydrozoa, largely following Rees (1957). Athecate classification has been extensively modified recently by Peters...

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Section: Rkmarksmentioning

confidence: 99%

Section: Remarksmentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

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Shallow-Water Hydroids of Bermuda. The Athecatae

Díaz¹,

Calder²

1991

Estuaries

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“…It has been speculated on various occasions as to whether congenital coagulation disorders may be associated with an inherent factor deficiency or an enzyme and protein defect respectively, or whether other factors which have escaped further definition may possibly affect the efficacy of the respective parameter [4,12,16,22,33,40]. In addition it has been pointed out that activation of factor VIII might proceed differently in hemophilia A and yon Willcbrand's diesease [23,29,36].…”

Section: Introductionmentioning

confidence: 99%

Serum immunoglobulins in patients with congenital coagulation defects and their relatives

1971

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Abstract. Quantitative estimations of serum IgG, IgA and IgM were performed in 30 individuals with congenital coagulation defects and in 47 related persons.The majority of patients with hemophilia, congenital defects of the prothrombin complex and congenital afibrinogenemia showed a significant elevation in one or more immunoglobulins. By contrast, normal immunoglobulin concentrations were recorded in 3 persons with yon Willebrand's disease, in 2 normal subjects with isolated factor VIII deficiency, and in 1 female patient with acquired deficiency of the liver-dependent clotting factors.In 11 out of 15 mothers of hemophiliacs immunoglobulin concentrations were significantly elevated. A high proportion of other relatives of these patients likewise showed significantly raised immunoglobulin concentrations. Follow-up tests on patients and their relatives over more than 1 year indicated that findings usually did not vary appreciably.On the basis of our study it is suggested that in patients with congenital coagulation defects elevated immunoglobulin concentrations are hereditary.

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“…I was recently able to demonstrate that the coagulation ir regularity in hemophilia A is associated with an inhibitor that seems to be a lipoprotein. I also succeeded in isolating platelet cofactor I from hemophilic plasma and found that hemophiliacs have normal amounts of this factor so that there is no deficiency involved in this disease [14,15]. This inhibitor only inhibits prothrombin activation under intrinsic clotting conditions, which means that it inhibits the action of both platelet cofactor I and autoprothrombin II (factor IX).…”

mentioning

confidence: 99%

The Purification and Properties of Platelet Cofactor I (Factor VIII)

Mammen¹

1963

Vox Sanguinis

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Investigations on the Nature of Hemophilia A

Cited by 11 publications

References 13 publications

Shallow-Water Hydroids of Bermuda. The Athecatae

Shallow-Water Hydroids of Bermuda. The Athecatae

Serum immunoglobulins in patients with congenital coagulation defects and their relatives

The Purification and Properties of Platelet Cofactor I (Factor VIII)

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