Investigations on plasma levels of mast cell mediators in acute atopic dermatitis

Amon, Ulrich; Menz, Ulrike; Wolff, Helmut H.

doi:10.1016/0923-1811(94)90023-x

Cited by 12 publications

(11 citation statements)

References 18 publications

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“…Several authors describe an increased density of mast cells in AD 1,2 and speculate on the pathophysiological relevance of mast cells in AD. 10 There is also some controversy about the role of histamine in AD patients. 7,8 However, mast cell density has not been shown to correlate with severity of AD, 9 and plasma levels of mast cell mediators in AD have been found to be normal.…”

mentioning

confidence: 99%

Mast cell mediators other than histamine induce pruritus in atopic dermatitis patients: a dermal microdialysis study

Rukwied

Lischetzki

McGlone

et al. 2000

British Journal of Dermatology

175

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While histamine is the crucial mediator of pruritus in type 1 allergic reactions, its role in atopic dermatitis (AD) is unclear. In this study, the role of mast cell mediators in protein extravasation and pruritus was evaluated using intradermal microdialysis. The microdialysis capillaries were used to apply the mast cell degranulating substance compound 48/80 (C48/80; 0.05%) or histamine (0.01%) and also to deliver H1-blockers (cetirizine, 200 microg mL-1) in nine AD patients and nine controls. Large pore size membranes (3000 kDa) enabled simultaneous analysis of protein extravasation. Itch sensation was measured psychophysically and weal and flare reaction were evaluated planimetrically. Protein extravasation induced by histamine and C48/80 was significantly reduced in AD patients. Blockade of H1-receptors by cetirizine significantly reduced C48/80-induced protein extravasation in AD patients and controls to an identical level. C48/80-induced pruritus was abolished by cetirizine in controls, whereas pruritus in AD patients was unchanged after H1 blockade. We conclude that mast cell mediators others than histamine are involved in C48/80-induced pruritus in AD patients. Whether the reduced capacity of AD patients to induce protein extravasation is of pathophysiological relevance for pruritus remains to be established.

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confidence: 99%

Mast cell mediators other than histamine induce pruritus in atopic dermatitis patients: a dermal microdialysis study

Rukwied

Lischetzki

McGlone

et al. 2000

British Journal of Dermatology

175

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“…When mast cells are activated by specific antigens, surface‐bound antigen‐specific IgE [22,26,27] or stress local degranulation of the secretory granules may occur [28]. This can cause release of vasoactive mediators and other biologically active molecules [14] and may induce the wheal‐and‐flare reaction of the skin [15,16]. This local reaction may play a role in CRPS1 and may cause the redness and swelling in the acute stage of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…wheal-and-flare reaction of the skin [15,16]. This local reaction may play a role in CRPS1 and may cause the redness and swelling in the acute stage of the disease.…”

Section: Discussionmentioning

confidence: 99%

IgE-Mediated Hypersensitivity: Patients with Complex Regional Pain Syndrome Type 1 (CRPS1) vs the Dutch Population. A Retrospective Study

Wesseldijk¹,

Toorenenbergen²,

Wijk

et al. 2009

Pain Med

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“…Several studies that have investigated a possible correlation between serum tryptase and skin diseases demonstrated that no such correlation exists [68,69]. This might suggest that tryptase is only active in the cutaneous level but not systemically.…”

Section: Tryptase In Skin Diseasesmentioning

confidence: 99%

Tryptase as an inflammatory marker in allergic disease and asthma

Bachelet¹,

Munitz²,

Levi‐Schaffer³

2005

Expert Review of Clinical Immunology

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Asthma is a chronic inflammatory disease of the airways, varying from occasional episodes of wheezing and shortness of breath, to an irreversible, life-threatening obstructive disease. While many cases are managed with relative ease, others do not respond to the traditional inhaled therapy or even to oral glucocorticosteroids. Although it cannot be cured as yet, asthma can be controlled if properly diagnosed. Usually, functional clinical parameters form the basis for estimation of the disease severity. In addition, the growing database of cytokine and mediator profiles have allowed their exploitation as molecular markers for processes underlying airway inflammation in asthma. Tryptase is a potent and versatile mediator in allergic inflammation, orchestrating both acute and chronic events by acting on a vast array of cells and tissue components. For more than a decade, tryptase has been used as a marker for allergic inflammation in asthma as well as in a variety of other airway diseases. In this review, the current advantages and disadvantages of the use of tryptase as an inflammatory marker in asthma will be discussed.

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Investigations on plasma levels of mast cell mediators in acute atopic dermatitis

Cited by 12 publications

References 18 publications

Mast cell mediators other than histamine induce pruritus in atopic dermatitis patients: a dermal microdialysis study

Mast cell mediators other than histamine induce pruritus in atopic dermatitis patients: a dermal microdialysis study

IgE-Mediated Hypersensitivity: Patients with Complex Regional Pain Syndrome Type 1 (CRPS1) vs the Dutch Population. A Retrospective Study

Tryptase as an inflammatory marker in allergic disease and asthma

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