Investigations on organo‐tin compounds. III. The biocidal properties of organo‐tin compounds

Abstract

The present paper gives an account of the results of a systematic investigation on the fungicidal It is shown that among these compounds one structural Within this type the influence on theThe toxicity of organo-tin compounds towards some other organisms is mentioned briefly. The final section deals with possibilities for practical applications of organo-tin compounds From the results of laboratory tests the preservation properties of organo-tin compounds.type in particular exhibits a very high fungicidal activity.activity of the nature of the various groups linked to tin has been investigated.as a consequence of their biocidal properties. of wood seems the most promising possibility.

Organotin Polyethers as Biomaterials

“…For alkylorganostannanes, toxicity varies depending on the alkyl group. In general an increase in the alkyl chain length gives a decrease in toxicity [1,2,23,24]. The particular pattern for methyl, ethyl, propyl, and butyl varies with test organism.…”

Binuclear diphenyltin(IV)dithiocarbamate complexes bearing functionalized linkers: Synthesis, spectral characterization, DFT and in vitro anticancer activity

“…[5] Thus, the limitations of platinum chemotherapeutic metallopharmaceuticals lead to development towards non-platinum chemotherapeutics aiming to increase the proficiency of such medications. [9][10][11] For instance, the initial biocidal properties of triorganotin compounds like tripropyltin, triphenyltin and tributyltin were studied by Van der Kerk and Luijten [12] during 1954, and these compounds were further known to battle the parasite that roots for schistosomiasis in human beings. [9][10][11] For instance, the initial biocidal properties of triorganotin compounds like tripropyltin, triphenyltin and tributyltin were studied by Van der Kerk and Luijten [12] during 1954, and these compounds were further known to battle the parasite that roots for schistosomiasis in human beings.…”

“…[6][7][8] Of these, organotins have been emerging as impending biologically active metallopharmaceuticals. [9][10][11] For instance, the initial biocidal properties of triorganotin compounds like tripropyltin, triphenyltin and tributyltin were studied by Van der Kerk and Luijten [12] during 1954, and these compounds were further known to battle the parasite that roots for schistosomiasis in human beings. [13,14] Besides, the crucial role of organotin compounds as potent antitumorogenic agents both in vitro and in vivo has also been established.…”

Organotins and quantitative-structure activity/property relationships

“…Significance of the X group in R 3 SnX derivatives has been reported to have minor effects on the biological activity of the compounds [2,9] unless X itself is biologically active or can assist the transport of the molecule to the active site. It has also been shown to be significant if the X group is chelated to the tin atom.…”

“…It was not until the 1950s that their toxicities were studied systematically [2,3]. The toxicity of organotins has been found to be a function of the number of organic groups attached to the tin atom, as well as to the nature of the organic group.…”