Investigations of thyroid hormones and antibodies based on a community health survey: the Busselton thyroid study

O’Leary, Peter; Feddema, Peter; Michelangeli, V. P.; Leedman, Peter J.; Chew, Gerard T.; Knuiman, Matthew; Kaye, Joey; Walsh, John P.

doi:10.1111/j.1365-2265.2005.02424.x

Cited by 145 publications

(148 citation statements)

References 53 publications

(92 reference statements)

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“…In our study, exclusion of at-risk individuals increased the lower bounds of the 95% TSH limit, but had no effect on the mean and upper range fT 4 concentrations in groups according to gender and age. In addition, the prevalence of mild hypothyroidism (TSH )4.5 mU/L) was approximately three-fold more common in females than males, consistent with earlier studies (11,24). Most studies established one reference interval for a population, as recommended by the NACB (8).…”

Section: Discussionsupporting

confidence: 70%

Serum thyrotropin and free thyroxine reference ranges as defined in a disease-free sample of French middle-aged adults

Estaquio

Valeix²,

Leenhardt³

et al. 2009

Clinical Chemistry and Laboratory Medicine

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Background: The goal of this study was to provide reference ranges for thyrotropin (TSH) and free thyroxine (fT 4 ) based on data collected from a diseasefree sample of French middle-aged adults. Methods: A total of 3218 subjects participating in the Supplé mentation en Vitamines et Miné raux Antioxydants (SU.VI.MAX) study had measurements for TSH, fT 4 and urinary iodine concentrations. Thyroid volume and structure were evaluated using standardized ultrasonography. We selected a disease-free sample which included 2338 subjects (1313 females aged 35-60 years and 1025 males aged 45-60 years) with normal thyroid imaging, no previously reported thyroid disease or use of thyroid medication, and no risk factors for thyroid dysfunction. Distribution of TSH and fT 4 was estimated in males and females. Results: The median (central 95% range) TSH serum concentrations for females were 1.79 mU/L (0.29-5.21 mU/L) for ages 35-44 years and 1.98 mU/L (0.27-6.94 mU/L) for ages 45-60 years (p-0.0001, for age). The median (central 95% range) for males

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Section: Discussionsupporting

confidence: 70%

Serum thyrotropin and free thyroxine reference ranges as defined in a disease-free sample of French middle-aged adults

Estaquio

Valeix²,

Leenhardt³

et al. 2009

Clinical Chemistry and Laboratory Medicine

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“…Certainly, TPOAb is more relevant than TgAb among those with elevated TSH in reports from Europe and the United States [2,16,17,18,19]. The prevalence of TgAb is higher than that of TPOAb in patients with Hashimoto's disease in reports from Japan [4,5], but not in the report from Europe [7].…”

Section: Discussionmentioning

confidence: 99%

Measuring thyroglobulin autoantibodies by sensitive assay is important for assessing the presence of thyroid autoimmunity in areas with high iodine intake

Hamada¹,

Noh

Okamoto

et al. 2010

Endocr J

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“…In recent studies, similar prevalence of positivity, 12.4% to 14% (35,43,106) Although the presence of TPOAb usually precedes the development of thyroid dysfunction, recent studies suggest that a hypoechoic ultrasound pattern may precede a biochemical TPOAb abnormality (108,109) (A,B) The paradoxical absence of TPOAb in some patients with unequivocal TSH abnormalities likely reflects the suboptimal clinical and methodological sensitivity and/or specificity of current TPOAb tests (25,109) (B,B).…”

Section: What Is the Proportion Of Positive Thyroid Antibodies In Thementioning

confidence: 99%

Clinical practice guidelines for the management of hypothyroidism

Brenta

Vaisman

Sgarbi

et al. 2013

Arq Bras Endocrinol Metab

124

123

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Introduction: Hypothyroidism has long been known for its effects on different organ systems, leading to hypometabolism. However, subclinical hypothyroidism, its most prevalent form, has been recently related to cardiovascular risk and also to maternal-fetal complications in pregnant women. Objectives: In these clinical practice guidelines, several aspects of this field have been discussed with the clear objectives of helping physicians treat patients with hypothyroidism, and of sharing some of our Latin American-based clinical experience. Materials and methods: The Latin American Thyroid Society commissioned a Task Force on Hypothyroidism to develop evidence-based clinical guidelines on hypothyroidism. A systematic review of the available literature, focused on the primary databases of MedLine/PubMed and Lilacs/SciELO was performed. Filters to assess methodological quality were applied to select the best quality studies. The strength of recommendation on a scale from A-D was based on the Oxford Centre for Evidence--based Medicine, Levels of Evidence 2009, allowing an unbiased opinion devoid of subjective viewpoints. The areas of interest for the studies comprised diagnosis, screening, treatment and a special section for hypothyroidism in pregnancy. Results: Several questions based on diagnosis, screening, treatment of hypothyroidism in adult population and specifically in pregnant women were posed. Twenty six recommendations were created based on the answers to these questions. Despite the fact that evidence in some areas of hypothyroidism, such as therapy, is lacking, out of 279 references, 73% were Grade A and B, 8% Grade C and 19% Grade D. Conclusions: These evidence-based clinical guidelines on hypothyroidism will provide unified criteria for management of hypothyroidism throughout Latin America. Although most of the studies referred to are from all over the world, the point of view of thyroidologists from Latin America is also given. Arq Bras Endocrinol Metab. 2013;57(4):265-99

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Investigations of thyroid hormones and antibodies based on a community health survey: the Busselton thyroid study

Cited by 145 publications

References 53 publications

Serum thyrotropin and free thyroxine reference ranges as defined in a disease-free sample of French middle-aged adults

Serum thyrotropin and free thyroxine reference ranges as defined in a disease-free sample of French middle-aged adults

Measuring thyroglobulin autoantibodies by sensitive assay is important for assessing the presence of thyroid autoimmunity in areas with high iodine intake

Clinical practice guidelines for the management of hypothyroidism

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