Measuring thyroglobulin autoantibodies by sensitive assay is important for assessing the presence of thyroid autoimmunity in areas with high iodine intake

Hamada, Noboru; Noh, Jaeduk Yoshimura; Okamoto, Yasuyuki; Ueda, Miki; Konishi, Toshiaki; Fujisawa, Toshimichi; Ito, Koichi; Ito, Kunihiko

doi:10.1507/endocrj.k09e-353

Cited by 12 publications

(6 citation statements)

References 21 publications

(21 reference statements)

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“…However, several previous studies have shown a good sensitivity of TUS for the diagnosis of early stages of Hashimoto's thyroiditis and subclinical hypothyroidism in non-pregnant subjects [14,15,16,18]. Similarly, the specificity of TPOAb in common population is high and was nearly 100 % for histological findings of Hashimoto's thyroiditis [19,20]. Consistently, we found relatively good concordance between TPOAb-positivity and ultrasound autoimmune pattern in controls (71-83 % according to several titers).…”

Section: Discussionsupporting

confidence: 87%

Low concordance between positive antibodies to thyroperoxidase and thyroid ultrasound autoimmune pattern in pregnant women

et al. 2011

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Section: Discussionsupporting

confidence: 87%

Low concordance between positive antibodies to thyroperoxidase and thyroid ultrasound autoimmune pattern in pregnant women

et al. 2011

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“…Hamada et al emphasized the importance of TgAb measurement for assessing the presence of thyroid autoimmunity in Japan [21]. In this study and other screening studies of Japanese healthy subjects, TgAb prevalence was almost doubled when compared to TPOAb prevalence (Table 2) [22,23].…”

Section: Discussionsupporting

confidence: 50%

Comparison of thyroglobulin and thyroid peroxidase antibodies measured by five different kits in autoimmune thyroid diseases

et al. 2017

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“…It has been reported that 12.8% of healthy Japanese adults had either or both AbTg and AbTPO, suggesting that the thyroid autoantibodies AbTg and AbTPO may be more prevalent in SSc patients compared with healthy individuals. In chronic thyroiditis, the frequency of AbTg is higher than that of AbTPO (97% vs 75%) . However, our study demonstrated that the frequency of AbTPO is higher than that of AbTg in SSc patients with AITD (77.3% vs 66.7%), and these findings are consistent with previous reports …”

Section: Discussionsupporting

confidence: 92%

Demographic and clinical features of autoimmune thyroid disorder in Japanese patients with systemic sclerosis

Toki

Motegi

Yamada

et al. 2014

The Journal of Dermatology

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Autoimmune thyroid disorders (AITD) are characterized by the impairment of the thyroid gland as a result of systemic or organ-specific autoimmune disorders, and the presence of antithyroid autoantibodies, such as antithyroglobulin antibody (AbTg) and antithyroid peroxidase antibody (AbTPO). Several studies have reported the association of AITD with systemic sclerosis (SSc). However, none of those studies analyzed the association between AITD and skin sclerosis in SSc patients. The aim of this study was to examine the demographic and clinical features of SSc patients with AITD treated in our department. Of a total of 210 SSc patients, we identified 30 with AITD (14.3%), including 29 with Hashimoto's disease (13.8%) and one patient with Graves' disease (0.5%), indicating that hypothyroidism was more common among SSc patients with AITD. All patients with AITD were female, and anticentromere antibody positivity, the complication of Sjögren's syndrome, severe facial skin sclerosis and atrophy of the thyroid gland were significantly prevalent in SSc patients with AITD. SSc patients with such clinical features may be at high risk of AITD and require regular follow up of thyroid function including ultrasonography and the examination of serum hormone levels to start an early treatment.

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Measuring thyroglobulin autoantibodies by sensitive assay is important for assessing the presence of thyroid autoimmunity in areas with high iodine intake

Cited by 12 publications

References 21 publications

Low concordance between positive antibodies to thyroperoxidase and thyroid ultrasound autoimmune pattern in pregnant women

Low concordance between positive antibodies to thyroperoxidase and thyroid ultrasound autoimmune pattern in pregnant women

Comparison of thyroglobulin and thyroid peroxidase antibodies measured by five different kits in autoimmune thyroid diseases

Demographic and clinical features of autoimmune thyroid disorder in Japanese patients with systemic sclerosis

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