Investigations of technetium-organohydrazine coordination chemistry. The crystal and molecular structures of [TcCl2(C8H5N4)(PPh3)2]·0.75C7H8 and [TcNCl2(PPh3)2]·0.25CH2Cl2

Abrams, Michael J.; Larsen, S.; Shaikh, Shahid N.; Zubieta, Jon

doi:10.1016/s0020-1693(00)81670-9

Cited by 52 publications

(37 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Various isomers can result from different bonding modalities of the hydrazine functionality of the HYNIC and the two tricine coligands [38]. Both Tc-hydrazido and Tc-diazenido bonds have been previously reported and characterized by X-ray crystallography [39,40]. These different bonding modalities from the tricine and hydrazine ligands are expected to produce numerous structural and stereoisomers.…”

Section: Resultsmentioning

confidence: 99%

Development of a 99mTc-labeled lactam bridge-cyclized alpha-MSH derivative peptide as a possible single photon imaging agent for melanoma tumors

et al. 2015

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Development of a 99mTc-labeled lactam bridge-cyclized alpha-MSH derivative peptide as a possible single photon imaging agent for melanoma tumors

et al. 2015

View full text Add to dashboard Cite

show abstract

“…A variety of chelators have been used as a bifunctional chelating agent (BFCA) in labeling proteins, peptides, and other biologically active molecules by 99m Tc . Among these, HYNIC is one of the candidates that can form monodentate diazenido complexes (TcNN–R) with the central metal.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and evaluation of a ^99mTc‐labeled tubulin‐binding agent for tumor imaging

Erfani

Shamsaei

Mohammadbaghery

et al. 2014

Labelled Comp Radiopharmac

View full text Add to dashboard Cite

Cholchicine and its derivatives are very potent tubulin-binding compounds and can be used as a potential tumor targeting agents. In this study, colchicine was labeled with (99m) Tc via hydrazinonicotinic acid (HYNIC) and was investigated further. HYNIC/cholchicine was synthesized and labeling with (99m)Tc was performed at 95 °C for 15 min and radiochemical analysis included HPLC method. The stability of radiconjugate was checked in the presence of human serum at 37 °C up to 24 h. Biodistribution was studied in breast tumor-bearing mice. Labeling yield of 95.8 ± 0.54% was obtained corresponding to a specific activity of 54 MBq/µmol. Radioconjugate showed good stability in the presence of human serum. Biodistribution studies in tumor-bearing mice showed that (99m) Tc/HYNIC/colchicine conjugate accumulated in tumor with good uptake (3.17 ± 0.14% g/g at 1 h post-injection). The radioconjugate was cleared fast from normal organs and showed clearance through urinary and hepatobiliary systems with accumulation of activity in kidneys and intestine. This radioconjugate may be useful to assess the presence of tumor by imaging.

show abstract

“…It has been proposed that the technetium oxidation state in the [ 99m Tc]tricine complex is +5 [55,88]. The oxidation state might change when HYNIC is bonded to the technetium center.…”

Section: Technetium Oxidation Statementioning

confidence: 99%

6-Hydrazinonicotinamide Derivatives as Bifunctional Coupling Agents for 99mTc-Labeling of Small Biomolecules

Liu¹

2005

Contrast Agents III

View full text Add to dashboard Cite

Investigations of technetium-organohydrazine coordination chemistry. The crystal and molecular structures of [TcCl2(C8H5N4)(PPh3)2]·0.75C7H8 and [TcNCl2(PPh3)2]·0.25CH2Cl2

Cited by 52 publications

References 36 publications

Development of a 99mTc-labeled lactam bridge-cyclized alpha-MSH derivative peptide as a possible single photon imaging agent for melanoma tumors

Development of a 99mTc-labeled lactam bridge-cyclized alpha-MSH derivative peptide as a possible single photon imaging agent for melanoma tumors

Synthesis and evaluation of a ^99mTc‐labeled tubulin‐binding agent for tumor imaging

6-Hydrazinonicotinamide Derivatives as Bifunctional Coupling Agents for 99mTc-Labeling of Small Biomolecules

Contact Info

Product

Resources

About

Investigations of technetium-organohydrazine coordination chemistry. The crystal and molecular structures of [TcCl2(C8H5N4)(PPh3)2]·0.75C7H8 and [TcNCl2(PPh3)2]·0.25CH2Cl2

Cited by 52 publications

References 36 publications

Development of a 99mTc-labeled lactam bridge-cyclized alpha-MSH derivative peptide as a possible single photon imaging agent for melanoma tumors

Development of a 99mTc-labeled lactam bridge-cyclized alpha-MSH derivative peptide as a possible single photon imaging agent for melanoma tumors

Synthesis and evaluation of a 99mTc‐labeled tubulin‐binding agent for tumor imaging

6-Hydrazinonicotinamide Derivatives as Bifunctional Coupling Agents for 99mTc-Labeling of Small Biomolecules

Contact Info

Product

Resources

About

Synthesis and evaluation of a ^99mTc‐labeled tubulin‐binding agent for tumor imaging