Investigations of animal blood samples after fragrance drug inhalation by gas chromatography/mass spectrometry with chemical ionization and selected ion monitoring

Abstract

The fragrance compounds linalool (1) and linalyl acetate (2) could be detected, identified and quantified (1: 7-9 ng ml-1; and 2: 1-2 ng ml-1 and 4-5 ng ml-1 as free linalool) in blood samples after inhalation in animal experiments (mice) by gas chromatography/mass spectrometry (GC/MS) with chemical ionization (CI) (ammonia); selected ion monitoring (SIM) mode (1: m/z 81, 137 and 154; 2: 47, 57 and 137) and GC/flame ionization detection (FID). The inhalation of these monoterpenes in concentrations of 5 mg l-1 air leads to a significant reduction of the motility of the test animals down to 30-40% with respect to the control group.

The hydroalcoholic extract of Salvia elegans induces anxiolytic- and antidepressant-like effects in rats

“…Psychopharmacological in vivo evaluation has shown that linalool possesses dose-dependent marked sedative effects at the CNS including hypnotic, anticonvulsant and hypothermic properties (Jirovetz et al, 1991). This evidence suggests that linalool may take account of at least some of the behavioral effects of Salvia elegans.…”

Fragrance: emerging health and environmental concerns

“…The motility of mice that inhaled linalool (a compound found in lavender) decreased 40%. 43 Even stimulation with caffeine did not return activity to normal levels.…”

Kuromoji (Lindera umbellata) Essential Oil Inhibits LPS-Induced Inflammation in RAW 264.7 Cells

“…10) Linalool, a monoterpene compound that is reportedly a major volatile component of the essential oils of several aromatic species, is used in traditional medicine systems to relieve symptoms and to cure various ailments, both acute and chronic. It was evaluated recently for its psychopharmacological activity in mice, revealing marked dose-dependent sedative effects on the central nervous system, 11,12) including protection against pentylenetetrazol, picrotoxin, and transcorneal electroshock-induced convulsion, and its hypnotic and hypothermic properties. 13) Furthermore, several recent reports have stated that linalool shows anti-proliferative activity against some solid tumor cells such as melanoma cells and renal cell adenocarcinoma cells 14) and HepG2.…”