Investigations for anthelmintic resistance in gastrointestinal nematodes from goats

Hall, Clifford; Ritchie, L. S.; McDonell, P.A.

doi:10.1016/s0034-5288(18)32534-7

Cited by 28 publications

(3 citation statements)

References 5 publications

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“…Closantel and ivermectin proved to be very effective against this strain of H. contortus, as was reported earlier (Hall et al, 1981;Santiago et al, 1986). Since these drugs had not been used on the farm, resistance against them was not expected.…”

Section: Resultssupporting

confidence: 69%

Multiple anthelmintic resistance in a field strain ofHaemonchus Contortus in goats

et al. 1992

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Section: Resultssupporting

confidence: 69%

Multiple anthelmintic resistance in a field strain ofHaemonchus Contortus in goats

et al. 1992

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“…According to field results, ivermectin at such a dose rate has excellent efficacy against the majority of the parasites that have been shown to affect Senegalese Peulh sheep. Moreover, it has been reported that ivermectin is highly effective against all the important pathogenic gastrointestinal nematodes in other breeds of sheep (Armour et al, 1982;Hall et al, 1981).…”

Section: Discussionmentioning

confidence: 99%

Ivermectin in Senegalese Peulh Sheep: Influence of Sex on Plasma Disposition

Ndong

Kane²,

Diouf³

et al. 2007

Vet Res Commun

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The plasma disposition kinetics of ivermectin following a single subcutaneous administration of 0.2 mg/kg was investigated in male and female Senegalese Peulh sheep. Ten clinically healthy animals (5 males and 5 females) weighing 38-45 kg were used in this trial. Blood samples were collected by jugular puncture at different times between 0.5 h and 30 days post treatment. After plasma extraction and derivatization, samples were analysed by HPLC with fluorescence detection. Computerized kinetic analysis was carried out and mean parameters were statistically compared with the Mann-Whitney U-test. The area under the concentration-time curve (AUC) was significantly higher (p < 0.0027) in females than in males. Although the differences in maximum concentration (C (max)), mean residence time (MRT) and half-life of elimination (t (1/2el)) between males and females did not achieve statistical significance, values tended to be higher in females. Sex differences may be parallel with the level of storage in fat. Further investigations are required to improve the use of ivermectin in Senegalese sheep and findings may be used to predict optimal anthelmintic strategies for management of African species depending on the parasites present in a production system.

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“…Earlier surveys and reports were restricted to single drug (or) single species of nematodes. Thereafter, the reports were extended to multi-generic resistance (Hall et al, 1981;Barton et al, 1985;Martin et al, 1985;Bauer et al, 1987;McKenna, 1989;Watson and Hosking, 1990;Hong et al, 1992) and multi drug resistance (Sangster et al, 1979(Sangster et al, , 1985Sangster, 1990Sangster, , 1996Van Wyk et al, 1987, 1989Jackson et al, 1992;Love et al, 1992;Uppal et al, 1992).…”

Section: Extent Of Resistance To Worldwidementioning

confidence: 99%