Investigation the Bioactivity of Cordierite/Hydroxyapatite Ceramic Material Used in Bone Regeneration

Because of their exceptional biological, mechanical, and structural capabilities, polymer matrix composite materials are immensely appealing in the biomedical industry, particularly for surface activation of metallic implants and tissue engineering. The purpose of this research is to investigate the effect of adding 5% active metallic particles (Mg particles and Ag nanoparticles) to an alginate matrix on cell survival (fibroblast MG-36 cells), antibacterial activity, surface texture, roughness, and wettability. The incorporation of 5% Mg particles and Ag nanoparticles in polymeric matrix employed composite material with outstanding properties. The adding of Mg and Ag particles boosted wettability by decreasing the contact angle from 56.83° to 0°. The activity of Candida albicans and Porphyromanoas gingivalis was significantly reduced, particularly with Ag nanoparticles, which fight bacteria by blocking cell development and improving the antimicrobial properties of composite materials. The use of Ag nanoparticles to strengthen alginate resulted in higher fibroblast proliferation for MG-63 cell at the outer layer, which resulted in superior cell viability (24, 48, and 72). Meanwhile, due to Mg's high activity, the reverse effect was found when Mg particles were used, making the composite surface more active (enriched with Mg ions).

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Investigation the Bioactivity of Cordierite/Hydroxyapatite Ceramic Material Used in Bone Regeneration

Cited by 3 publications

References 29 publications

In Vivo and In Vitro Biological and Histological Evaluation of Cordierite-Hydroxyapatite Ceramic Grafting Powder During Maxillary Sinus Augmentation in Rabbit Model

In Vivo and In Vitro Biological and Histological Evaluation of Cordierite-Hydroxyapatite Ceramic Grafting Powder During Maxillary Sinus Augmentation in Rabbit Model

Preparation and Characterization of Hybrid Composite Material for Maxillary Sinus Augmentation

Enhancing the cell viability and antibacterial properties of alginate-based composite layer by adding active particulates

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